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New therapy aims to retrain the brain in kids with Seizure-Like episodes

NCT ID NCT05096273

Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 27, 2026 · Updated 3 times

Summary

This study tests a new cognitive behavioral therapy called ReACT for children aged 9-18 with psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on helping kids feel more in control and less afraid of their symptoms. Over 12 sessions, researchers will measure changes in sense of control, pain tolerance, and seizure frequency, with follow-ups up to a year later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Retraining and Control Therapy (ReACT) - a cognitive behavioral therapy
What this could lead to
If it works, this could provide an effective behavioral treatment to reduce seizures and improve quality of life for children with PNES.
What could go wrong
This is a small, early-stage study with only 68 participants, so results may not apply to everyone. The therapy requires active participation and may not work for all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 68 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2021

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

11 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 9-18 years old. * Diagnosis of psychogenic non-epileptic seizures by a medical doctor using video-EEG. * Family member (parent if a minor) willing to participate and that the subject with PNES chooses. Exclusion Criteria: * Comorbid Epilepsy * Less than 4 PNES per month * Other paroxysmal nonepileptic events (e.g. episodes related to hypoxic-ischemic phenomena, sleep disorders or migraine-associated disorders) * Participation in other therapy * Severe intellectual disability * Severe mental illness (delusions/hallucinations) Exclusion for CPT: * Blood pressure \>130/80 mmHg for adolescents greater than or equal to 13 years old * Either systolic and/or diastolic blood pressure greater than or equal to 95% based on sex and age for children less than 13 years old

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Conditions

The condition(s) this trial relates to.

conversion disorder visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Convulsion, non-epileptic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sparks Center Office of Psychiatric Research

    RECRUITING

    Birmingham, Alabama, 35294, United States

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