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A clap of thunder: could a hand clap diagnose seizures?

NCT ID NCT07742709

Diagnosis Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether a sudden, loud hand clap can help doctors quickly tell apart epileptic seizures from psychogenic non-epileptic seizures (PNES), which look similar but have different causes. About 400 people undergoing video-EEG monitoring will receive the clap test during a seizure episode, and their reactions will be recorded. The goal is to see if this simple, low-cost test can provide a fast and accurate diagnosis, potentially reducing the need for more complex procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Abrupt Clap Provocation Test (a diagnostic procedure using a sudden loud hand-clap to observe reactions during seizures)
What this could lead to
If effective, this could provide a rapid, low-cost way to distinguish epileptic seizures from psychogenic non-epileptic seizures, improving diagnosis and treatment.
What could go wrong
The test's accuracy may vary, and it might not replace standard video-EEG monitoring. It's a single-center study, and results need confirmation in broader settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of patients with suspected epilepsy referred for 24-hour continuous video-electroencephalography (VEEG) monitoring at the Department of Neurology, Xijing Hospital. Eligible participants are individuals of any gender, typically young to middle-aged adults, who experience at least one clinical paroxysmal episode with prominent convulsive or motor abnormalities during the monitoring period. The core analyzed cohort comprises patients who successfully undergo the Abrupt Clap Provocation Test (ACPT) during the ictal phase and subsequently receive a definitive diagnosis of either epileptic seizures (ES) or psychogenic non-epileptic seizures (PNES; Level 4 certainty according to the International League Against Epilepsy criteria). Patients with pre-existing severe hearing loss, other non-epileptic paroxysmal disorders (e.g., syncope, sleep disorders), or those whose seizure events are obscured or occur outside the camera's view are excluded.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Continuous video-electroencephalogram (VEEG) monitoring duration of 24 hours or longer * At least one recorded episode during VEEG monitoring with prominent abnormal limb movements (such as convulsive episodes) * Successful administration of the standardized Abrupt Clap Provocation Test (ACPT) during the clinical ictal phase * Episodes definitively diagnosed as epileptic seizures (ES) or confirmed as psychogenic non-epileptic seizures (PNES) at the highest certainty level (Level 4: documented/confirmed) according to the International League Against Epilepsy (ILAE) criteria * Complete clinical and demographic data available Exclusion Criteria: * Coexisting severe hearing impairment or documented ear disease, rendering the patient unable to effectively perceive normal auditory stimuli * Episodes definitively diagnosed as other non-epileptic paroxysmal disorders (such as syncope, paroxysmal kinesigenic dyskinesia, or sleep disorders) * Episodes occurring out of the camera view, obscured, or recorded with poor video quality, preventing accurate assessment of ictal behavioral responses to the clap stimulus * Severe lack of clinical data, loss to follow-up, or refusal/withdrawal of informed consent

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Conditions

The condition(s) this trial relates to.

conversion disorder epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epilepsy Psychogenic non-epileptic seizures

Contacts and locations

Locations

  • No.127 Changle West Road, Xincheng District, Xi'an, Shaanxi 710048, China

    Shanxi, China

  • The First Affiliated Hospital of Air Force Medical University (Xijing Hospital)

    Xian, Shanxi, China

  • The First Affiliated Hospital of Air Force Medical University (Xijing Hospital)

    Shanxi, China

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Other studies related to the condition(s) this trial covers.