EPILEPSY

This study tests the long-term safety of an experimental drug, RAP-219, in 30 adults with refractory focal epilepsy (seizures that don't respond well to current treatments). Participants must have completed a previous related study. The main goal is to check for side effects, whi…

This study tests whether a special music app, used at home, can reduce seizure-related brain activity in adults with drug-resistant epilepsy who have a brain implant (RNS). Twenty-four participants will listen to either the study music or a placebo sound over several months. The …

This study tests brain surgery for children and adults with epilepsy that medication cannot control. Participants will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, though some patients may still need ongoi…

This study tests a non-invasive brain stimulation technique called tDCS in 60 people with epilepsy that doesn't respond to medication. Participants will receive either real or sham (fake) stimulation for 10 days to see if it safely reduces seizure frequency. The goal is to improv…

This early-stage trial tests a new cell therapy (UX-GIP001) for adults with drug-resistant mesial temporal lobe epilepsy. Six participants will receive an injection of special brain cells designed to calm overactive nerve signals. The main goal is to check safety and see if it re…

This study follows 210 people with epilepsy who already have a Minder device implanted. The device helps doctors make better treatment decisions after a seizure or other actionable event. Participants will be monitored every six months for two years to see how the device improves…

This early-stage trial tests an experimental drug called ASO-GNAO1 (Tianasen) in 5 children aged 1-14 with a specific GNAO1 gene mutation that causes severe epilepsy and uncontrolled movements. The drug is given via spinal injections over 12 months to see if it can reduce seizure…

This study tests whether an AI-enhanced version of the Medilepsy® app helps underserved teens and young adults (ages 14-24) with epilepsy take their anti-seizure medication more consistently. The app sends reminders and tracks adherence, and the AI version personalizes these prom…

This study looks at whether removing a brain tumor and the nearby area causing seizures can reduce or stop those seizures. About 100 people aged 8 and older with brain tumors and related seizures will have surgery and be followed for up to a year. The goal is to see if surgery im…

This study looks at whether taking levetiracetam three times a day works better than the usual twice-daily schedule for adults with uncontrolled epilepsy. About 120 participants will track their seizures and side effects in a diary. The goal is to see if the new dosing leads to m…

This study tests a new medicine called SPN-817 in 60 adults whose seizures are not controlled by current treatments. The main goal is to see if the drug is safe and tolerable. Researchers will also track how much seizure frequency changes during the study.

This study tests an experimental drug, RAP-219, in 333 adults with focal seizures (a type of epilepsy). Participants will take the drug or a placebo for several weeks to see if it safely reduces how often seizures happen. The goal is to find a new treatment option for people whos…

This study tests whether sharing epilepsy care tasks with trained non-specialists, supported by an electronic medical records system, helps people in western Kenya take their medication regularly and stay in care. About 650 people with epilepsy who are not currently taking their …

This study tests whether a new tool called BioEP can help doctors diagnose epilepsy more accurately. About 559 adults who have had a first suspected seizure and a normal EEG will take part. The tool analyzes EEG results to give doctors extra information to support their diagnosis…

This study will use a special brain scan called magnetoencephalography (MEG) to see if it can help doctors better diagnose children with conditions like epilepsy, autism, ADHD, and other brain disorders. Researchers will compare MEG signals from 1,500 children with these conditio…

This study tests whether levetiracetam, a seizure medication, can prevent epileptic seizures in adults over 40 with Down syndrome who also have Alzheimer's disease. 120 participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop se…

This study tests whether giving the drug sirolimus early can prevent or delay seizures in infants with tuberous sclerosis complex (TSC). About 64 babies under 7 months old will receive either sirolimus or a placebo. The goal is to see if early treatment can protect brain developm…

This early-phase study tests whether everolimus, a drug that targets the mTOR pathway, can safely reduce seizures when added to standard treatment for adults with focal refractory epilepsy. Five participants aged 18-60 will take everolimus only during seizure events and be monito…

This study tests a new educational program called ReBOOT for adults with epilepsy who are about to have brain surgery. The goal is to see if the program can lower the risk of memory or thinking problems after surgery, or help those who do have problems. Participants attend virtua…

This study compares two 8-week telephone programs for 120 adults with epilepsy who have mild to moderate depression. One program teaches skills to manage depression, while the other offers peer support groups. Researchers will track changes in mood, quality of life, and seizures …

This study tests a sleep improvement program for children with epilepsy, who often have worse sleep problems than other kids. The program combines clinic visits with technology support to help children sleep better and improve health for both the child and their parents. About 15…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds extra support from a care manager to usual neurology care, aiming to improve emotional well-being and quality of life. Participants must be 18 o…

This study tracks 50 people in Japan who receive a midazolam mouth solution for status epilepticus (a long-lasting seizure). Doctors will record side effects over 6 months and check if the drug stops seizures within 10 minutes. The sponsor does not control treatment; clinics foll…

This early study tests a new, non-invasive treatment for people with temporal lobe epilepsy that doesn't respond to medication. It uses low-intensity focused ultrasound to calm overactive brain areas. The main goal is to see if the treatment is safe and tolerable, and to check if…

This study tests whether methylphenidate, a drug used for ADHD, can help with memory and attention problems caused by epilepsy. About 226 adults with epilepsy will be randomly assigned to take the drug or a placebo for 8 weeks, then everyone can take the drug for another 2 months…

This study is tracking 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep problems, anxiety, depression, or epilepsy. Researchers will use standard questionnaires to measure changes in symptoms over 24 weeks. The goal is to see how well medical cann…

This study is testing whether high doses of vitamin D can reduce seizures, ease fatigue, and improve quality of life in adults with epilepsy. Researchers will give participants vitamin D supplements and track their symptoms for three months. The goal is to see if this simple, low…

This study tests whether L-serine, a dietary supplement, can improve overall functioning in 40 children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by specific gene variants. Each participant will receive both L-serine and a placebo in alter…

This study tests a device called NaviFUS™ that uses low-intensity focused ultrasound to calm overactive brain areas causing seizures. It is for adults with epilepsy that does not respond to medication. The goal is to see if this treatment can safely reduce seizure frequency. Sixt…

This study is testing a program that teaches people with epilepsy how to use rescue medication to manage repeated seizures. The program is adapted from an existing self-management tool (SMART) with input from patients, caregivers, and doctors. About 30 adults with epilepsy who ha…

This study tests whether creating a personalized lullaby can improve quality of life and reduce stress, anxiety, and depression in pregnant women with epilepsy. Thirty first-time mothers-to-be will be randomly assigned to either take part in the Lullaby Project or receive standar…

This study tests whether a non-invasive light treatment called photobiomodulation (PBM) can lower stress and improve seizure control in adults with epilepsy. Participants will attend 45 sessions over 15 weeks and wear a special ring to track health data. The goal is to see if thi…

This study looks at whether listening to Mozart or other age-appropriate music can lower the number of seizures or abnormal brain signals in children with epilepsy. Ten children aged 4 to 17 staying in a hospital epilepsy monitoring unit will participate. Researchers will measure…

This study gathers information from 500 children worldwide who have both epilepsy and movement disorders. Researchers will review medical records and genetic data to find patterns linking these conditions. The goal is to better understand these rare diseases and guide more person…

This study looks at whether routine EEG (brain wave testing) can help predict epilepsy in people who have had a stroke. Researchers will monitor 100 stroke patients to find hidden seizures and identify who is at risk for developing epilepsy later. The goal is to improve early det…

This study looks at medical records of 1000 children with conditions like autism, epilepsy, and Down syndrome to find common biological patterns. Researchers want to understand what causes these disorders and how children respond to treatments. The goal is to improve diagnosis an…

This study aims to understand why some people with epilepsy die suddenly (SUDEP). Researchers will monitor how seizures affect breathing, heart function, and the ability to wake up. They will test how well the body senses carbon dioxide levels. About 335 adults with epilepsy will…

This study looks at people with epilepsy that doesn't get better with medication. These patients already need brain electrodes to find where seizures start. Researchers want to see if using a wider range of electrical stimulation frequencies can better pinpoint the seizure zone a…

This study aims to see if special brain recordings taken during thinking tasks can predict memory or attention problems after epilepsy surgery. About 50 adults with drug-resistant epilepsy who are already scheduled for brain-mapping surgery will participate. Researchers will comp…

This study looks at better ways to diagnose and treat people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. Researchers will use advanced imaging and tests to pinpoint the exact seizure source and gui…

This study uses three types of brain scans (PET, MRI, and EEG) to see how epilepsy affects brain activity and energy use. Researchers will compare scans from 30 healthy adults and people with epilepsy. No treatment is given—the goal is simply to learn more about the condition.

This study looks at whether people who have their first seizure after age 50 should be checked for hidden heart and stroke risks like high blood pressure or diabetes. Researchers will screen 420 participants and track if starting treatments for these risks lowers their chance of …

This study looks at kidney function in 100 children with epilepsy, ages 1 month to 15 years. Researchers will test blood, urine, and use ultrasound to see if long-term seizure medicines cause kidney problems. The goal is to understand risks, not to test a new treatment.

This study tests a new Italian program designed to help teenagers with epilepsy transition from pediatric to adult healthcare. Researchers will compare teens who go through the program with those who receive standard care, measuring how many attend their first adult clinic appoin…

This study tests whether a special type of MRI, called resting-state fMRI, can predict how well children with drug-resistant epilepsy will do after brain surgery. Researchers will scan 200 children aged 6-18 before surgery and analyze brain network patterns using graph theory. Th…

This study is looking for specific smells (volatile organic compounds) that people with epilepsy might give off before, during, or after a seizure. Researchers will collect odor samples from 100 adults with drug-resistant epilepsy during a hospital stay. The goal is to identify t…

This study aims to understand how the vagus nerve works by recording its electrical signals in awake people with epilepsy. Researchers will use a thin needle to listen to nerve activity, both with and without a vagus nerve stimulator device. The goal is to learn which nerve fiber…

This study looks at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions or locations, compared to healthy volunteers. Researchers want to see if TLE patients forget spatial details faster over several weeks. The goal is to better understand …

This study aims to find out why some people with epilepsy do not get surgery that could help them. Researchers will survey patients and doctors to identify barriers, then test an educational program that teaches patients about social factors affecting surgical access. About 310 a…

This observational study looks at how controlled sensory stimulation, such as music, affects brain function in people with epilepsy and healthy volunteers. Researchers will map brain networks and measure changes in anxiety and depression. No treatment is given; the goal is to bet…

This study aims to understand how the brain processes language by recording brain activity from people with epilepsy who already have electrodes implanted for medical reasons. Researchers will compare these brain signals to computer models of language to see which models best mat…

This study looks at how the body's energy use and immune system may be different in children with autism, epilepsy, brain tumors, or other brain conditions. Researchers will collect blood samples and do behavioral tests in 500 children up to age 17. The goal is to find patterns t…

This study tests whether a small device worn in the ear can safely and accurately detect seizures by measuring brain waves. Researchers will first try it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if…

This study aims to better understand epilepsy and find new ways to help people whose seizures don't improve with medication. Researchers will screen up to 1,000 adults and children aged 8 and older using tests like brain scans and EEGs. The goal is to identify participants who ma…

This study looks at how the brain learns to control fine movements, like playing a musical instrument. Researchers will ask 50 people already scheduled for awake brain surgery (for epilepsy or brain tumors) to use a theremin-like device. By recording brain activity directly, they…

This study aims to better understand how brain activity relates to mood in people with depression and epilepsy. Researchers will use precise brain recordings and artificial intelligence to analyze mood changes. The goal is to improve treatments for depression and other mental hea…

This study looks at how bacteria in the gut and mouth are linked to epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1500 people with newly diagnosed epilepsy and healthy volunteers. By analyzing thes…

This study follows 1,000 children with rare epileptic syndromes like West and Dravet syndrome over time. Researchers will track how different treatments affect seizure frequency and the child's thinking and behavior. The goal is to gather real-world data to help doctors and famil…

This study tests a small device placed under the scalp that records brain activity in people with epilepsy whose standard tests were unclear. About 210 adults with drug-resistant epilepsy will either get the device or continue usual care. The goal is to see if the device helps do…

This study involves epilepsy patients who already have electrodes in their brain as part of their surgical evaluation. Researchers will record brain activity while participants perform tasks like looking at pictures, watching videos, or answering questions. The goal is to learn e…

This study tests whether a special micro-electrode can safely record the activity of individual brain cells during epileptic seizures. It involves 30 adults with drug-resistant epilepsy who are already scheduled for brain surgery. The goal is to learn more about how seizures work…

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will use special brain recordings from people with epilepsy or depression to find markers that show TMS is working. The goal is to use these markers to make TMS more effective…

This study is testing whether a new digital test battery called Mindmore Distance can accurately assess thinking and memory skills in people with neurological conditions like traumatic brain injury, stroke, multiple sclerosis, Parkinson's disease, epilepsy, or brain tumors. Resea…

This study looks at how a drug called scopolamine changes brain activity related to memory. Researchers will test 60 adults with epilepsy who are already having brain surgery for seizure monitoring. Participants will do memory tasks after receiving either the drug or a saltwater …

This study looks at how children with epilepsy learn things without trying, like picking up new skills or habits. Researchers will compare 40 children with epilepsy to healthy children using a simple computer task. The goal is to see if this type of learning is affected by epilep…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study follows up to 150 people with MEHMO syndrome or related disorders to track how the disease progresses over time. Researchers will collect medical history, imaging, and lab samples to identify biological markers. The goal is to better understand these conditions and dev…

This study aims to better understand rare genetic disorders that affect brain development, such as Baker Gordon Syndrome and Syt-1 disorder. Researchers will collect medical data, genetic samples, and other information from 100 participants of all ages to track how these conditio…

This study aims to understand how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers will use special electrodes placed inside the brain to record activity while participants perform mood-related tasks. The …

This study looks at how the hippocampus, a brain area important for memory, behaves when people explore what they see. Researchers will record brain activity in epilepsy patients who already have electrodes implanted for medical reasons. The goal is to understand brain signals du…

This study looks at how the brain's arousal systems respond to different senses like sight and sound. Researchers will use brain scans and recordings from healthy volunteers and epilepsy patients to measure brain activity during tasks. The goal is to understand shared brain pathw…

This study surveys 400 adults with epilepsy in France to understand why they are less physically active than the general population. Researchers will look at how fear, stigma, and personal beliefs about epilepsy affect exercise habits. The goal is to find better ways to help peop…

This study looks at how the brain manages emotions when facing a threat. Researchers will record brain activity and use mild electrical stimulation in people with epilepsy who already have electrodes implanted for medical reasons. The goal is to understand brain connections invol…

This study is testing a new type of EEG called tripolar EEG (tEEG) to see if it can detect seizures more accurately and with less interference than standard EEG. About 90 adults and children with epilepsy will wear both devices at the same time. The goal is to compare how well ea…

This study looks at how breathing and waking from sleep are connected in people with drug-resistant epilepsy. Researchers will measure carbon dioxide levels and breathing responses during deep sleep in 60 participants (30 with epilepsy and 30 healthy volunteers). The goal is to b…

This study compares two advanced brain-mapping techniques—MEG and high-resolution EEG—to see which better pinpoints the exact area causing seizures in people with drug-resistant epilepsy who are candidates for surgery. One hundred participants will undergo both scans before their…

This study is testing whether a special MRI dye called mangafodipir is safe and can better show areas of the brain affected by epilepsy in people whose seizures are not controlled by medication. About 40 adults aged 18-60 with drug-resistant epilepsy will receive the dye and have…

This study is testing a low-cost, ear-worn device that can detect and predict seizures in real time. About 40 adults with epilepsy will wear the device while staying in the hospital for standard monitoring. The goal is to see how accurately the device can spot seizures and even p…

This study looks at how well doctors follow recommended epilepsy management guidelines for pregnant women with epilepsy. Researchers will track pregnancy, delivery, and baby outcomes, as well as the mother's seizure control. About 80 participants will be observed to see if follow…

This study aims to create detailed brain maps that show where important functions like thinking and effort are located in people with epilepsy. Researchers will use mild electrical stimulation on the brain's surface during hospital monitoring for epilepsy surgery. The goal is to …

This study tests whether adding a risk prevention program to standard epilepsy education helps adults with uncontrolled epilepsy manage their safety better. 74 participants will be split into two groups: one gets the extra program, the other gets usual care. The main goal is to s…

This study aims to understand how ketamine produces feelings of dissociation—like being detached from your body or surroundings. Researchers will give ketamine to 20 adults with epilepsy who are already staying in a monitoring unit. They will measure dissociative symptoms using a…

This study aims to build a system called CAMERA that uses signals from the brain, body, and behavior to measure and predict anxiety and memory. About 40 adults with epilepsy who are already undergoing brain monitoring will participate. The goal is to create a tool that can contin…

This study looks at how well different brain scan methods can find the exact spot in the brain where seizures start in people with epilepsy that doesn't get better with medicine. Researchers will compare scan results before and after surgery to see which methods work best. They w…

This study aims to uncover genetic factors that contribute to epilepsy and related disorders. Researchers will analyze DNA from up to 5,000 people with epilepsy to find gene changes linked to the condition. The goal is to better understand why epilepsy varies so much from person …

This study looks at how the brain creates seizures by using very small electrical currents to trigger them safely in children with hard-to-control epilepsy. Researchers will stimulate nearly all electrode contacts already placed in the brain for monitoring, to map the seizure net…

This study aims to find genetic heart problems that might explain why some people with epilepsy die suddenly. Researchers will test 600 adults aged 18-50 with epilepsy, seizures, or related events, plus their blood relatives. They use advanced gene sequencing to look for known he…

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

This study uses a powerful 7T MRI scanner to look at brain structure and function in people with migraine, visual snow, or epilepsy, and compares them to healthy volunteers. The goal is to better understand how these conditions affect the brain and why they often occur together. …

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. By tracking ch…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study explores whether combining a driving simulator with an EEG (a brain activity test) can better assess driving ability in people with epilepsy. Researchers will measure attention, reaction time, and driving performance in 40 adults with epilepsy who hold a valid driver's…

This study looks at how vagus nerve stimulation (VNS) changes the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. It is not a treatment study—it aims to learn how VNS works. About 144 adults aged 18 and olde…

This study aims to improve how doctors plan epilepsy surgery by using advanced MRI scans to map brain connections. Researchers will compare these scans with electrical recordings from inside the brain in 290 people with drug-resistant epilepsy. The goal is to develop noninvasive …

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) changes how the stomach works. Researchers will measure stomach emptying and capacity in 16 adults who already have the device. The goal is to understand the connection, not to test…

This study looks at whether measuring fast-ripples (very fast brain waves) during epilepsy testing can help surgeons decide where to operate. About 440 adults with drug-resistant epilepsy will take part. Half will have special electrodes that detect fast-ripples; the other half w…