EPILEPSY

This study is testing a new brain implant system designed to detect early warning signals of epileptic seizures and deliver targeted electrical stimulation to prevent seizures from occurring. Researchers are working with 12 adults and children with drug-resistant epilepsy to see …

This study is observing how well the drug cenobamate works for adults with focal epilepsy whose seizures are not controlled by at least two other medications. It follows 936 patients in Italy for one year to see how much it reduces seizure frequency and to check for side effects.…

This study is testing the safety and early effectiveness of an implanted brain stimulation device for people with a severe form of epilepsy called Lennox-Gastaut Syndrome (LGS). The device, called the RNS System, is designed to detect and respond to abnormal brain activity to hel…

This study is testing whether playing very low, gentle sounds through headphones during sleep can help reduce seizures and abnormal brain activity in adults with epilepsy. Researchers are checking if people can comfortably use the sound system at home every night and measuring if…

This study aims to see how well an add-on anti-seizure medication works for adults with focal epilepsy in real-world settings. It will follow 300 patients for 12 months to measure changes in seizure frequency, safety, and quality of life. The goal is to understand the drug's effe…

This study aims to find safe ways to lower high cholesterol in adults with epilepsy who are on a special high-fat, low-carb diet that controls their seizures. Researchers will test if making small changes to the diet or adding a common cholesterol-lowering pill (a statin) can imp…

This study is testing the safety and basic function of a new brain implant system for people with severe, hard-to-treat epilepsy. The device senses brain activity, uses a computer program to predict seizure risk, and can deliver small electrical pulses to try to prevent seizures …

This small pilot study is testing whether stimulating a specific, deep part of the brain called the medial pulvinar can reduce seizures in people with epilepsy that hasn't responded to drugs, surgery, or other devices. It involves 12 adults who have tried and failed other treatme…

This study is following 140 adults with severe epilepsy who have received a surgically implanted brain stimulation device. The goal is to collect three years of real-world data to see how well the device continues to reduce seizure frequency and to monitor for any long-term safet…

This study is testing whether an experimental drug called BHV-7000 can reduce abnormal brain activity in people with epilepsy who have a special implanted brain device (RNS System). Five participants will take the drug for four weeks, and researchers will compare their brain reco…

This study is testing whether using a specific brain wave measurement from a scalp EEG can help doctors find the best settings for a vagus nerve stimulator (VNS) device. The VNS is already implanted in people with epilepsy that doesn't respond well to medication. Researchers want…

This study is testing special smart glasses designed to detect patterns in brain activity that may predict when an epileptic seizure is about to happen. The glasses have built-in sensors that read brain signals without needing messy gels. Researchers are checking how well the gla…

This study is testing a small, implanted device that records brain waves continuously for 40 days in people with uncontrolled epilepsy. The goal is to see if the device works reliably and safely over a long period. It aims to provide doctors with better long-term data to understa…

This study is testing a small device implanted under the scalp to monitor brain activity for up to 15 months in people with epilepsy and intellectual disability. The goal is to see if this long-term monitoring is safe, acceptable, and can accurately detect seizures that might oth…

This study aimed to use advanced brain scanning to find the exact spots in the brain that cause seizures in people with hard-to-treat epilepsy. The goal was to create a better, non-invasive map to guide surgeons, potentially helping more people become seizure-free after surgery. …

This study is testing a new, easy-to-use EEG (brain wave recording) headset designed to improve access to epilepsy diagnosis for Veterans living in rural areas. The dry-electrode headset doesn't require a specialist to operate and could be used in local clinics as part of a teleh…

This study aimed to test a wearable device called EpiCare@Home for detecting epileptic seizures. The device, worn behind the ear, records brain activity, heart rate, and movement to help doctors monitor seizures more accurately than patient diaries. The trial was withdrawn before…

This study is testing a new psychological therapy program designed to help adults with epilepsy. The program aims to improve memory, reduce anxiety and depression, and enhance overall quality of life. Researchers will compare results between people who start the therapy right awa…

This study aims to understand how well healthcare professionals in Saudi Arabia know and follow safety guidelines for the epilepsy medication Depakine (sodium valproate). Researchers will survey 3,500 doctors, pharmacists, and specialists who prescribe or dispense this medication…

This study aims to understand how a common brain stimulation technique works during surgery for epilepsy or brain tumors. Researchers will observe patients already scheduled for surgery as they perform simple language tasks. The goal is to learn how stimulation affects brain cell…

This study follows 300 children who had seizures as newborns to understand how their genes might affect their risk of developing epilepsy later in childhood. Researchers are collecting genetic information along with brain scan and medical history data to try to build better tools…

This study aims to understand how the human brain processes speech across different languages. Researchers will record brain activity from 52 patients with epilepsy or brain tumors who are undergoing surgery where electrodes are already placed on their brain surface. By testing h…

This research study aims to understand how seizures spread in the brain and how memory works in people with epilepsy. Researchers will examine specific brain regions using special monitoring equipment already placed for medical care. The goal is to gather knowledge that could inf…

This study aims to understand how sleep helps memory and if playing quiet, timed sounds during sleep can improve it. It involves 24 epilepsy patients who already have special electrodes implanted for medical monitoring. Researchers will measure brain activity and test memory afte…

This study aims to determine which of two common anesthesia drugs (fentanyl or ketamine) works better for mapping brain activity during surgery for children with brain tumors and epilepsy. Doctors place electrodes directly on the brain during surgery to identify areas causing sei…

This study aimed to understand if gentle electrical stimulation, delivered through electrodes already placed in the brain for epilepsy surgery planning, could improve a person's working memory. It planned to test this in adults with drug-resistant epilepsy. The goal was to gather…

This study is creating a large international database to collect information from about 8,000 people who had a stroke and later developed seizures (post-stroke epilepsy). Researchers will analyze this data to better understand how seizures affect recovery and to build a tool that…

This study aims to learn how memory works by recording brain activity in epilepsy patients who already have electrodes implanted for their medical care. Researchers will have participants play memory games on a computer while monitoring their brain signals, and may gently stimula…

This study aims to understand how repeated seizures in people with Dravet Syndrome affect the body's automatic functions like breathing and heart rate. Researchers will monitor 92 children and adults with this severe form of epilepsy during sleep and around the time of their seiz…

This study aims to understand the long-term effects of ketogenic diets on heart health in adults with epilepsy. Researchers are measuring cholesterol, blood pressure, weight, and artery wall thickness over two years. The study includes adults already on the diet and those startin…