EPILEPSY

This study looks at 22 adults with epilepsy who have been on a modified Atkins diet for at least a year and have high cholesterol. Researchers will test whether reducing saturated fat in the diet or taking a statin can safely lower cholesterol without affecting seizure control. T…

This study looks at how cenobamate works in adults whose focal seizures are not controlled by at least two other epilepsy drugs. Researchers will track seizure frequency before and during treatment to see if seizures drop by half or more. The goal is to better understand the drug…

This study tests whether stimulating a specific part of the brain called the pulvinar can reduce seizures in people with epilepsy that does not respond to medication. Twelve adults aged 18 to 60 who have not been helped by surgery or vagal nerve stimulation will receive deep brai…

This study tests a self-management program for adults with epilepsy in Uganda. The program includes group sessions and phone follow-ups over 24 weeks. Researchers will measure changes in seizure frequency and quality of life compared to usual care. 190 participants are enrolled.

This study tests a brain-responsive neurostimulation system in 24 people aged 12 and older with Lennox-Gastaut syndrome whose seizures are not controlled by medication. The device is implanted in the brain and delivers electrical stimulation when it detects seizure activity, aimi…

This study tests a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The drug aims to reduce abnormal electrical activity linked to seizures. Participants take the drug for 4 weeks, and researchers compare brain recordi…

This study tests a new dry electrode EEG headset that is easier to use than standard EEGs and does not require a specialist to operate. The goal is to help Veterans with epilepsy in rural areas get diagnosed more easily. Researchers will compare the new headset to standard EEGs i…

This study tests whether adjusting vagal nerve stimulator settings based on brain wave patterns (called PLI) can reduce seizures more than standard settings. About 140 people with drug-resistant epilepsy who already have a vagal nerve stimulator will take part. The goal is to fin…

This study planned to see if a brain-computer interface (BCI) could improve attention in children with epilepsy who do not respond to medication. Participants would have used brain electrodes already placed for epilepsy surgery to train their attention with visual feedback. The s…

This study tests a psychological and cognitive rehabilitation program for 70 adults with active epilepsy. The program is designed to improve quality of life, memory, and emotional well-being. Participants will be randomly assigned to start the program right away or after a waitin…

This study explores whether playing a low-frequency sound (1 Hz) during deep sleep can reduce seizure activity in people with epilepsy. Thirty-six adults will use a smartphone app and special headphones at home for two months. The goal is to see if this simple, non-invasive appro…

This study looks at brain tissue from 10 people with temporal lobe epilepsy and hippocampal sclerosis who are having surgery. Researchers will analyze gene activity in the tissue to understand what causes the disease and find possible markers for better treatment. The goal is to …

This study follows about 300 children who had seizures shortly after birth, along with their parents, to see if genes affect the risk of developing epilepsy later in childhood. Researchers will use medical records, brain scans, and genetic tests to create a tool that predicts low…

This study looks at 88 children having brain tumor surgery who also have epilepsy. Doctors want to know which anesthetic drug—fentanyl or ketamine—better helps them see seizure signals on brain monitors during the operation. The goal is to improve how surgeons find and remove the…

This study aimed to use high-frequency brain signals to better understand how the brain works in people with epilepsy, migraines, and other conditions. Researchers planned to create a database of these signals to improve diagnosis and treatment. However, the study was withdrawn b…

This study looks at how repeated seizures may harm breathing and heart control in people with Dravet syndrome, a severe form of epilepsy. Researchers will monitor 92 children and adults over 24-48 hours to measure changes in breathing and heart rate during and between seizures. T…

This study observes 300 adults with focal onset seizures who are starting an add-on anti-seizure medication. Researchers will track changes in seizure frequency and quality of life over 12 months in real-world settings. The goal is to understand how well these medications work ou…

This study looks at how electrical brain stimulation (ECS) affects the brain during surgeries for epilepsy or brain tumors. Researchers want to understand how ECS changes brain cell activity and how it affects speech and language areas. About 65 adults having brain surgery will d…

This study tests whether a brain implant can safely track seizures, mood, and thinking in people with epilepsy. Five participants with hard-to-control seizures will use the device, which also delivers brain stimulation to try to prevent seizures. The goal is to see if the system …

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older already on a keto diet or starting the modified Atkins diet.…

This study aims to understand how the brain processes spoken language by recording brain activity in people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Researchers will compare brain signals from English, Spanish, and Mandarin speakers…

This study tests a new brain recording system (Brain Interchange) in up to 12 people with drug-resistant epilepsy who are already scheduled for brain monitoring. The system is used externally to see if it can detect special brain signals (high-frequency oscillations) better than …

This study was designed to test a wearable device called EpiCare@Home that tracks brain, heart, and body signals to detect focal seizures. Researchers planned to enroll adults and teens with epilepsy and compare the device's readings to standard hospital monitoring. The goal was …

This study looks at how the brain forms and recalls memories by recording brain activity in people with epilepsy who are already having brain surgery. Participants do memory tasks like recalling words or navigating a virtual town while their brain signals are recorded. The goal i…

This study tests a tiny device placed under the scalp that tracks brain activity 24/7 in people with epilepsy and mild to moderate intellectual disability. The goal is to see if it can accurately detect seizures, improve quality of life, and be comfortable and easy to use. Nine a…

This study looks at how small electrical pulses to the brain can change working memory—the kind you use to remember a phone number. Researchers will work with 50 epilepsy patients who already have electrodes in their brains for monitoring. Participants will play a memory game whi…

This study was designed to collect and analyze fluid from the part of the brain being removed during epilepsy surgery. The goal was to look for signs of inflammation that might lead to new ways to control seizures in people who don't respond to medication. The study was withdrawn…

This study looks at how short bursts of noise played during sleep might help strengthen memory in people with epilepsy who have electrodes implanted in their brain. Researchers will measure brain activity and memory performance over several nights. The goal is to understand how s…

This study looks at how two small parts of the brain's thalamus are involved in spreading seizures and forming memories. Researchers will record brain activity from 100 epilepsy patients who already have electrodes implanted for medical reasons. The goal is to better understand t…

This study tests a new, highly detailed PET/CT scanner (NeuroEXPLORER) against standard scanners for people with conditions like dementia, Parkinson's, epilepsy, brain tumors, and head/neck cancers. About 1,600 participants will get both scans in one visit to see if the new scann…

This study tests a new wireless device implanted under the scalp that records brain activity for over a year in people with uncontrolled epilepsy. Nineteen adults will use the device day and night to see how well it captures seizures and how safe it is. The goal is to improve lon…

This study tests special smart glasses that read brain waves to predict epileptic seizures. About 47 adults with epilepsy will wear the glasses while researchers check how safe and accurate they are. The goal is to help people with epilepsy get early warnings before a seizure hap…

This study aimed to see if rhythmic electrical stimulation of the brain could improve working memory in people with drug-resistant epilepsy. Researchers planned to test this in patients already undergoing brain surgery monitoring. However, the study was withdrawn before any volun…

This study gathers information from 8,000 people who had a stroke and later developed seizures or epilepsy. Researchers will analyze this data to understand how these patients recover and to create a tool that predicts who might develop epilepsy after a stroke. The goal is to imp…