EPILEPSY

This study followed 345 people with epilepsy who already had a brain implant called the RNS System to see how safe and effective it is over 5 years in everyday medical practice. The device detects and responds to seizure activity to help control seizures. The goal was to confirm …

This study tested a mobile health program to help children (ages 2–12) with newly diagnosed epilepsy take their seizure medication as prescribed. The program included education, automated reminders, and personalized feedback. The goal was to improve medication adherence, reduce s…

This study tested whether naloxone, a drug that reverses opioid overdoses, can help people with epilepsy breathe better right after a seizure. About 485 adults with drug-resistant epilepsy were monitored in the hospital. If they had a seizure, they received either naloxone or a p…

This study tested whether adding brivaracetam to existing epilepsy medications could safely reduce partial seizures in adults aged 16 to 80. Over 400 participants took either the drug or a placebo for 12 weeks. The main goals were to check for side effects and measure how much se…

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized based on each patient's seizure zone, previously mapped with brain electrodes. Researchers measured changes in seizure freque…

This study tested whether training community health workers to treat childhood epilepsy can help more children get care. Over 1,600 children in Nigeria took part. The goal was to see if this approach could help children become seizure-free for at least 6 months.

This study looked at whether adding a low dose of lacosamide to levetiracetam is more effective than increasing the dose of levetiracetam alone for adults with epilepsy who still had seizures on a low dose of levetiracetam. Fifty-six adults participated, and the main goal was to …

This study looked at the safety of brivaracetam, a seizure medicine, when added to current treatment for children with epilepsy. A total of 257 children took part. The main goal was to track any side effects over time.

This study compared two oral seizure medications, brivaracetam and levetiracetam, in 102 children aged 1 month to 14 years with newly diagnosed epilepsy. The goal was to see which drug better stopped seizures and caused fewer side effects. Children who had never taken long-term s…

This study looked at how well the drug levetiracetam works for controlling seizures in people aged 60 and older with epilepsy. Researchers tracked how many patients stayed seizure-free, how long they continued the medication, and how well they tolerated it. The goal was to see if…

This study tested a system called Nelli that uses cameras and artificial intelligence to detect seizures in children aged 6 to 21. The system was compared to the standard method, video-EEG, which uses electrodes on the scalp. The goal was to see if Nelli could correctly identify …

This study tested a device called NaviFUS™ that uses focused ultrasound to calm overactive brain areas causing seizures. It included 12 adults with epilepsy that did not respond to medication. The main goal was to check safety and see if it could reduce how often seizures happen.…

This study tested whether taking coenzyme Q10, a natural supplement, could help reduce seizures in adults whose epilepsy does not respond to standard medications. 39 participants took either coenzyme Q10 or a placebo for 12 weeks while continuing their usual seizure drugs. The ma…

This study tested whether taking zinc by mouth every day is safe and doable for people with GNAO1-related disorders, a rare genetic condition causing movement problems, seizures, and developmental delays. Thirteen participants aged 6 months to 30 years took zinc for 6 months. Res…

This study tested a device called STARSTIM that delivers a mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimula…

This study tested whether virtual reality (VR) exposure therapy could help people with epilepsy who feel anxious about their seizures. Fourteen adults used VR for 5 minutes twice a day over 10 days. Researchers measured anxiety, depression, and quality of life before, after, and …

This study tested whether a single inhaled dose of Staccato Alprazolam can reduce seizure-related brain activity in people with photosensitive epilepsy. Five adults aged 18 to 60 with a history of light-triggered brain responses took part. Researchers measured changes in brain wa…

This study tested whether a gentle neck massage, given three times a week for eight weeks, could help people with epilepsy feel more confident managing their condition and reduce symptoms. It also looked at whether the massage eased the burden on caregivers. The study involved 96…

This small pilot study tested whether intermittent fasting (eating only during an 8-hour window each day) could reduce seizures in 22 adults whose epilepsy did not respond to medication. Some participants also took medium-chain triglycerides (MCTs), a type of fat. The goal was to…

This study looked at whether foot reflexology massage can help people with epilepsy. 70 adults with epilepsy received the massage, and researchers measured changes in seizure frequency, fatigue, stress, and sleep quality. The goal was to see if this gentle, non-drug therapy could…

This study tested whether a 12-week, at-home step-count program is practical for people with epilepsy. Twenty-six adults with epilepsy used a Garmin watch to track their steps and attended virtual coaching sessions. The goal was to see if participants could stick with their step …

This study tested a technique called thermocoagulation in 100 children with focal drug-resistant epilepsy. Doctors used tiny electrodes to apply heat to the part of the brain causing seizures, aiming to reduce seizure frequency for weeks or months. The goal was to ease symptoms a…

This study looked at whether practicing mindfulness meditation can improve quality of life and brain activity in people with epilepsy that doesn't get better with medication. About 37 adults and teens with this type of epilepsy, plus some healthy volunteers, took part. Researcher…

This study tested a wearable cap that shines near-infrared light on the brain (called tPBM) in 6 autistic children aged 4–12 who also had abnormal brain waves or epilepsy. The children wore the device twice a week for 10 weeks. Researchers looked for improvements in focus, speech…

This study looked at whether the ADHD rating scale can track changes in attention problems in children with epilepsy. Researchers enrolled 173 children aged 6 to 15 with both epilepsy and ADHD. The goal was to see if the scale is sensitive enough to measure improvement over 12 to…

This study tested a new high-density EEG method to map brain areas involved in movement, sensation, language, emotion, and thinking. It included 122 people with epilepsy, brain tumors, and healthy volunteers. The goal was to improve understanding of brain function and seizure act…

This study looked at how the brain processes speech sounds in 48 people with epilepsy who already had electrodes placed in their brains for medical reasons. Researchers measured brain activity while participants listened to sounds with varying voice pitch and timing. The goal was…

This study compared four different methods (using online forms or electronic health records) to screen adults with epilepsy for anxiety and depression. Researchers wanted to see which method led to more patients completing the screening before their clinic visit. The goal is to i…

This study tested a computer system called Nelli that uses video cameras and machine learning to automatically spot seizures. 33 people with epilepsy were monitored in a hospital unit. The goal was to see how well the AI could detect seizures compared to the standard brain-wave t…

This study aimed to create a computer algorithm that can detect epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers studied 40 epilepsy patients who had seizures recorded during long-term monitoring. The goal was to see how accurately t…

This study looked at whether video recordings of people's faces and voices can help measure mood in a more continuous and objective way. Eleven adults with depression and epilepsy took part. Researchers compared these audio-video signals with brain activity and mood ratings to se…

This study tested whether a computer model of the brain, called a 'virtual brain,' could help doctors better understand electrical signals from epilepsy patients. Twenty people with epilepsy who were already scheduled for brain surgery took part. The goal was to see if the model …

This study tested a new, more affordable type of brain activity sensor (optical pumping magnetometer) for MEG imaging in 4 adults with epilepsy. The goal was to see if these sensors can detect abnormal brain signals as well as current expensive sensors. If successful, this techno…

This study looked at the educational, work, and social difficulties people with epilepsy face due to stigma and misconceptions. Researchers surveyed 90 adults with epilepsy to understand their experiences. The goal is to find unmet needs and help improve support and quality of li…

This study looked at how different settings of vagus nerve stimulation (VNS) affect heart rate and throat muscles in 16 adults with epilepsy. Researchers measured these effects during surgery to implant or replace a VNS device. The goal was to find ways to program the device to r…

This study explored why some children with autism develop epilepsy and whether physical exercise can make a difference. Researchers collected blood samples, sleep data, and cognitive tests from 50 children aged 10-15 with autism, epilepsy, or both. Participants also took part in …

This study looked at whether safety information about the epilepsy drug Depakine (sodium valproate) is reaching doctors and pharmacists in Saudi Arabia. Researchers surveyed 455 healthcare professionals to see if they read the materials and know how to use the drug safely. No pat…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily living abilities to find risk factors for disabilities. The goal is to better understand long-term outcomes and help …

This study tested whether special microelectrodes can record 'fast ripples'—tiny brain signals that may help pinpoint where seizures start. 54 adults with drug-resistant epilepsy who already needed brain monitoring took part. The goal was to see if these new electrodes work bette…

This study tested a new version of the drug NPT 2042 to see how well it is absorbed compared to the original version. Eight healthy adults took both forms, and researchers measured drug levels in their blood. The goal was to gather information, not to treat any disease.

This study looked at how epilepsy affects the daily lives of 90 adults. Researchers used a questionnaire called QOLIE-31 to measure well-being, energy, and emotions. The goal was to better understand what matters most to people living with epilepsy, not to test a new treatment.

This completed study looked at how epilepsy medicines behave in 753 children from birth to age 18. Researchers built computer models to understand how factors like weight, age, and genetics affect drug levels in the body. The goal was to help doctors give the right dose to each c…

This study followed 72 newborns who had seizures shortly after birth to see if inflammation plays a role in later developing epilepsy. Researchers measured seizure activity and checked how many children later developed epilepsy. The goal was to better understand the link between …

This study tested whether a special education program helps adults with epilepsy feel better day-to-day. Researchers compared quality of life scores between a group that received the education and a group that did not. The goal was to see if learning more about epilepsy and how t…

This study tested a mobile app designed to educate parents and caregivers of children with epilepsy. The app provides information about the condition, tracks symptoms, and helps manage appointments. Researchers compared 36 families who used the app with 36 who received standard c…

This study looked at how weak electric currents applied to the scalp change brain activity in people with drug-resistant focal epilepsy. Twelve adults undergoing brain monitoring for epilepsy received mild stimulation while their brain signals were recorded. The goal was to measu…

This study looked at how deep brain stimulation (DBS) influences the way people approach or avoid difficult decisions. Researchers tested 13 adults with DBS implants for severe depression or OCD, plus epilepsy patients with temporary brain electrodes. Participants played a comput…

This study measured the electrical fields created by a non-invasive brain stimulation technique called tDCS in 30 adults with epilepsy who already had electrodes implanted in their brains for medical reasons. The goal was to collect real-world data to improve computer models that…

This study tested two versions of the seizure drug stiripentol (capsules vs. a liquid suspension) in 24 healthy adults to see if they work the same in the body. The goal is to offer a more convenient option for people with Dravet syndrome, a severe childhood epilepsy. Participant…

This study looked at how epilepsy surgery affects the daily lives of people with drug-resistant epilepsy. Researchers surveyed 151 patients who had surgery at least two years ago to understand their satisfaction and quality of life. The goal was to see if patients' personal exper…

This study looked at how playing sounds during sleep affects brain activity and memory in children with Rolandic epilepsy. Researchers used brain scans and memory tests to understand which brain circuits are involved. The goal is to find new ways to treat childhood epilepsy. The …

This study involved 13 adults with drug-resistant epilepsy to create a database for developing a seizure detection algorithm. Researchers used a wearable patch to record heart rate and movement, while patients also underwent video-EEG monitoring as the gold standard. The goal is …

This study looked at how brain scans (fMRI and MEG) relate to electrical signals recorded directly from the brain (intracranial EEG) in people with epilepsy and healthy volunteers. The goal was to better identify the area causing seizures and map healthy brain networks to avoid d…

This study tested a new computer system that uses artificial intelligence to help doctors better diagnose and treat complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected information from 635 people, including healthy volunteers, to see if the …

This study looked at whether ketamine, a common sedative, might raise the chance of seizure-like brain activity compared to two other sedatives (midazolam and propofol). Researchers monitored 300 adults without epilepsy who were getting sedation for a routine stomach scope proced…