EPILEPSY

This study directly compared two common seizure medications, brivaracetam and levetiracetam, in children just starting treatment for epilepsy. It involved 102 children aged 1 month to 14 years. The goal was to see which drug was safer and more effective at stopping seizures compl…

This study tested whether shining a special near-infrared light on the brain could help children with autism. Six children aged 4-12 with autism and specific abnormal brain wave patterns wore a special head device twice a week for 10 weeks. Researchers looked for improvements in …

This study tested whether adding a new medication called brivaracetam helps reduce the number of partial seizures in people with epilepsy. It involved 449 participants aged 16 to 80 who were still having seizures despite taking one or two other anti-seizure drugs. The goal was to…

This study tested how well the seizure medication levetiracetam works for people aged 60 and older with epilepsy. Researchers followed 137 patients to see if the drug could keep them seizure-free, how long they could stay on it, and what side effects they experienced. The goal wa…

This small pilot study tested whether taking a daily zinc supplement for six months is safe and practical for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. Researchers enrolled 13 participants, aged 6 mont…

This study tested a smartphone-based program to help children with epilepsy take their medication more consistently. It involved 268 children, aged 2-12, who were newly diagnosed. The program provided families with education, digital reminders, and personalized feedback to help t…

This study aimed to check the long-term safety and effectiveness of a drug called brivaracetam for children with epilepsy. It involved 257 children who took the drug as an add-on to their regular seizure medications. Researchers tracked side effects and measured how well the drug…

This small pilot study explored whether a time-restricted eating pattern (16:8 intermittent fasting), with or without a daily dose of MCT oil, could help reduce seizures in adults whose epilepsy does not respond well to medication. Twenty-two participants tried both diet approach…

This study tested a procedure called thermocoagulation in children with severe, drug-resistant epilepsy. During a standard pre-surgery brain monitoring period, doctors applied tiny, precise heat burns to the specific brain area causing seizures. The goal was to see if this could …

This study tested whether specially trained community health workers could provide epilepsy care for children in Nigeria as effectively as doctors. It aimed to close the huge treatment gap where most children with epilepsy in Africa go untreated. The trial compared seizure contro…

This study tested whether Nelli software—which uses computer vision and machine learning—can automatically detect epileptic seizures from video recordings. Researchers compared the software's seizure detection against expert review of video EEG data in 150 children and young adul…

This study tested whether a software program called Nelli could automatically detect epileptic seizures at night using video and audio. It compared Nelli's performance to the current gold-standard hospital monitoring method (video-EEG) in 33 adults suspected of having seizures. T…

This study aimed to develop a computer algorithm that can automatically detect epileptic seizures by continuously analyzing a person's heart signals (electrocardiogram or ECG). Researchers tested the algorithm using existing recordings from 40 patients with epilepsy who had under…

This study tested a wearable patch to see if it could automatically detect epileptic seizures. The patch tracked heart rate and body movement in 13 adults with epilepsy. Researchers compared the patch's data to hospital brain scans to train a computer program to recognize seizure…

This study tested four different ways to send mental health screening questionnaires to adults with epilepsy before their doctor's appointments. Researchers wanted to see if sending the questionnaires by text message, email, or through an online patient portal (with or without a …

This study tested whether a single dose of naloxone (a medication that reverses opioid effects) given right after a major seizure could help patients breathe better and recover faster. Researchers enrolled 485 adults with hard-to-treat epilepsy who were being monitored in the hos…

This small study tested whether a 12-week walking program, delivered by video call and using a step-tracking watch, was practical for people with epilepsy. Researchers wanted to see if encouraging more daily steps could improve mood, sleep, and quality of life. They compared a co…

This study tested whether practicing mindfulness meditation could improve quality of life and ease anxiety and depression for people with epilepsy that doesn't respond well to medication. It involved 37 participants, including people with epilepsy and healthy volunteers, who lear…

This study tested whether a specific type of neck massage could help adults with epilepsy. Researchers wanted to see if the massage improved patients' confidence in managing their condition, reduced their symptoms, and lessened the stress on their caregivers. For eight weeks, hal…

This study tested whether using virtual reality (VR) exposure therapy could help reduce anxiety specifically related to having seizures in people with epilepsy. Fourteen adults who were already in the hospital for epilepsy monitoring were randomly assigned to either try the VR th…

This study tested whether a special education program could improve the quality of life for people with epilepsy. 80 patients were split into two groups: one received educational sessions about managing their condition, while the other received standard medical care. Researchers …

This study aimed to understand if the sedative ketamine might increase the risk of seizures in patients during medical procedures, compared to other common sedatives. Researchers monitored 300 adults without epilepsy who were undergoing a stomach exam with sedation. They used bra…

This study tested a new type of brain electrode to see if it could reliably record very fast brain signals called 'fast ripples.' Researchers wanted to know if these signals could help doctors more accurately locate the source of seizures in patients whose epilepsy does not respo…

This study followed children who had seizures as newborns to understand how these early seizures affect long-term development. Researchers tracked about 280 children from nine U.S. hospitals, assessing their thinking skills, behavior, and daily living abilities as they grew. The …

This study aimed to improve epilepsy surgery by comparing different brain scanning methods. Researchers measured brain activity in 47 epilepsy patients and healthy volunteers using multiple techniques simultaneously. The goal was to better identify seizure-causing brain areas and…

This study aimed to understand why children with autism have a higher risk of developing epilepsy and to see if regular physical exercise could help. Researchers enrolled 50 children, aged 10-15, with autism and/or epilepsy to measure their genes, brain activity, sleep, and think…

This study aimed to test how well a specific questionnaire (the ADHD-IV rating scale) can detect changes in attention and hyperactivity symptoms in children who have both epilepsy and ADHD. Researchers followed 173 children aged 6-15 to see if the scale's scores changed over 12-1…

This study aimed to understand if inflammation in a newborn's body after seizures is linked to developing epilepsy later in childhood. Researchers followed 72 newborns who had seizures shortly after birth, measuring substances in their blood related to inflammation. The goal was …

This study aimed to understand how the brain processes speech sounds in different situations. Researchers measured brain activity in 48 epilepsy patients who already had electrodes implanted for medical reasons. They listened to speech sounds while researchers recorded how their …

This study aimed to better understand how different settings on a Vagus Nerve Stimulation (VNS) device affect the nerve and cause side effects. Researchers measured nerve activity, muscle twitches in the throat, and heart rate changes in 16 adults with epilepsy while they were ha…

This study aimed to better understand how the brain works by using a high-density EEG cap to record brain waves. Researchers worked with 122 participants, including people with epilepsy, brain tumors, and healthy volunteers. Participants wore the cap while resting or performing s…

This study tested whether a mobile phone app could help parents and caregivers of children with epilepsy. 72 participants in Canada were randomly assigned to either use the educational app for 7 weeks or receive standard clinic information. Researchers measured if using the app i…

This study aimed to understand how children's bodies process and respond to common epilepsy medications. Researchers analyzed data from 753 children with epilepsy to learn how factors like age, weight, and genetics affect drug levels in the blood. The goal was to use this informa…

This study aimed to measure exactly how a gentle, non-invasive brain stimulation technique called tDCS creates electrical fields in the brain. Researchers worked with 30 adults who already had electrodes implanted in their brains for epilepsy surgery planning. By measuring the cu…

This study tested how the body absorbs a new liquid form of the drug stiripentol, used for a severe form of childhood epilepsy called Dravet syndrome. Researchers compared it to the standard capsule form in 24 healthy adults to see if they work similarly. The goal is to provide a…