Zapping seizures away: targeted brain stimulation offers new hope for epilepsy
NCT ID NCT04782869
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized using prior brain recordings to target the exact area causing seizures. The goal was to see if this approach could safely reduce seizure frequency and improve mood.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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17 people
The number who actually took part.
- Started
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Mar 2021
- Finished
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Feb 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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12 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \- Age: Older than 12 years old * Patients with drug-resistant focal epilepsy with no surgical indication or with a previous surgical failure or refusing surgery. * SEEG previously performed before inclusion with an adequate definition of the epileptogenic zone * A clinical or research MRI scan that is suitable for navigated brain stimulation (NBS) and definition of target area. * Number of seizures \>3/month during the baseline (before the first session of tDCS treatment), for at least 3 months * Have stable medications for the whole study duration and few weeks before * Total IQ\>65 * Be able to understand, speak and write in French * Patient, parents or legally representative who have given written informed consent to allow the study data collection procedures, * Be a beneficiary of affiliated to a health insurance plan Exclusion Criteria: * \- Generalized epilepsy * Presenting contraindication to MRI, a serious intercurrent pathology, a progressive brain tumor * Skin conditions (e.g., eczema, lesion) * Any cranial metal implants (excluding \<1 mm thick epicranial titanium skull plates and dental fillings) or medical devices (i.e. cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant). * Previous surgeries opening the skull leaving skull defects capable of allowing the insertion of a cylinder with a radius greater or equal to 5 mm. * Metal inside the head (outside the mouth) such as shrapnel, surgical clips * Patient currently participating in another clinical trial or having participated in a clinical trial in the month prior to inclusion. * Any condition that makes the study subject, in the opinion of the investigator, unsuitable for the study. * Person protected by articles L1121-5, L1121-6 and L1121-8 of Public Health Code (pregnant or breastfeeding woman, deprived of liberty by judicial decision, situations of social fragility, adults unable or unable to express their consent).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Service d'Epileptologie et de Rythmologie Cérébrale
Marseille, 13005, France
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Other studies related to the condition(s) this trial covers.
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