Heat zaps seizures: new hope for kids with Drug-Resistant epilepsy
NCT ID NCT02886650
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming to reduce seizure frequency for weeks or months. The main goal was to see if at least half of the children experienced a 50% or greater drop in seizures.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2015
- Finished
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May 2024
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 months to 17 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * age 18 month to 17 years old * focal drug-resistant epilepsy * small size lesion (1 or 2 gyri) or cryptogenic epilepsy * indication for EEG monitoring with depth electrodes during presurgical evaluation Exclusion Criteria: * formal contraindication to surgery or anaesthesia * functional area or potentially large epileptic area * refusal to participate in the study * no health insurance coverage
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fondation Ophtalmologique Adolphe de Rothschild
Paris, 75019, France
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Other studies related to the condition(s) this trial covers.
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