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Epilepsy breakthrough? naloxone may stop fatal breathing pauses after seizures

NCT ID NCT02332447

First seen Oct 31, 2025 · Last updated May 22, 2026 · Updated 28 times

Summary

This study tested whether naloxone, a drug that reverses opioid overdoses, can help people with epilepsy breathe better right after a seizure. About 485 adults with drug-resistant epilepsy were monitored in the hospital. If they had a seizure, they received either naloxone or a placebo. The goal was to see if naloxone speeds up recovery of normal oxygen levels, which could lower the risk of sudden unexpected death in epilepsy (SUDEP).

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Contacts and locations

Locations

  • Service de Neurologie Fonctionnelle et d'Epileptologie et Institut des Epilepsies Hôpital Neurologique

    Lyon, France

Conditions

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