Hospices Civils De Lyon

This study tests if hydroxychloroquine, a drug used for malaria and autoimmune diseases, can help people with sarcoidosis take less steroids. About 140 adults with sarcoidosis affecting areas outside the lungs (like skin, eyes, or bones) will receive either hydroxychloroquine or …

This study tests whether a drug called interferon gamma can help intensive care patients recover more quickly from pneumonia they get while on a ventilator. The drug aims to boost the immune system, which is often weakened after severe illness or injury. About 132 adults will rec…

This study tests whether a mechanical heart pump (LVAD) helps people with advanced heart failure live longer and feel better compared to taking standard heart medicines alone. About 92 adults with end-stage heart failure who are still able to walk around will be enrolled. The goa…

This study looks at whether giving a second course of a targeted radiation drug (Lu-PSMA) can help men with advanced prostate cancer that has stopped responding to hormone therapy. About 58 men who previously benefited from this treatment will receive it again. The goal is to see…

This study tests a new way to treat total blindness caused by severe eye burns or rare diseases that destroy the eye's surface stem cells. Doctors take a small sample of cells from the patient's cheek, grow them into a thin sheet in the lab, and transplant it onto the eye to rest…

This study looks at whether taking a low dose of prednisone for 10 months (instead of stopping after 1 month) helps prevent relapses in people with ANCA-associated vasculitis who are already on rituximab maintenance therapy. About 146 adults with inactive disease will be randomly…

This study tests whether a team of pharmacists and doctors working together can help people with rheumatoid arthritis take their medications as prescribed. About 200 adults with RA will be split into two groups: one gets this collaborative care starting in the hospital and contin…

This study looks at whether nurses can take a bigger role in starting methadone treatment for people with opioid use disorder. Currently, doctors must renew prescriptions every two weeks, but there often aren't enough doctors. The study will involve 182 adults starting methadone …

This study is for women with advanced ovarian, fallopian tube, or peritoneal cancer whose tumors did not shrink enough with standard chemotherapy. Researchers are testing a new method called PIPAC, which delivers chemotherapy as a spray directly into the abdomen, alongside standa…

This study looks at whether robot-assisted weight-loss surgery is worth its higher cost compared to standard laparoscopic surgery. About 482 adults with obesity will be randomly assigned to one of the two surgical methods. Researchers will track complications, quality of life, an…

This study tests whether starting a personalized home therapy program soon after birth can reduce the severity of cerebral palsy in babies at high risk. Researchers will compare motor skills at age 2 between infants who receive the early program and those who get standard care. T…

This study looks at whether delaying radiation therapy can help protect memory and thinking skills in people with a certain type of slow-growing brain tumor (low-grade oligodendroglioma with 1p/19q codeletion). About 280 adults who need treatment beyond surgery will be randomly a…

This study tests whether spironolactone, a medication that blocks certain hormones, can slow the worsening of heart function and reduce dangerous heart rhythms in people with arrhythmogenic right ventricular dysplasia (ARVD), a rare genetic heart disease. About 120 adults with AR…

This study looks at 250 ICU patients with acute kidney injury who need dialysis. Many have too much fluid in their body, which can harm recovery. The trial compares a faster fluid removal rate (2 ml/kg/h) with a slower one (0-1 ml/kg/h) to see which helps patients get off breathi…

This study tests a combination of two immunotherapy drugs (domvanalimab and zimberelimab) in people with five types of rare advanced cancers that have stopped responding to standard treatment. The goal is to see if this treatment can control the cancer better than older therapies…

This study tests a new device that filters excess iron from the blood in people with myelodysplastic syndrome (MDS) or myelofibrosis who cannot take standard iron-removing medications. Participants will undergo three short dialysis-like sessions over one week. The goal is to see …

This study tests larynx (voice box) transplants in 3 adults who have permanently lost the ability to speak, breathe on their own, or swallow due to severe injury. The goal is to restore these functions using a donor larynx. Because the body may reject the new organ, patients must…

This study tests a special program called PROADAPT for women aged 70 and older (or 60+ with health issues) who have advanced ovarian cancer and need surgery. The program includes nutrition advice, physical exercises, and education before surgery, plus extra support during the hos…

This study aims to improve diagnosis of respiratory viral infections in elderly patients by measuring a natural immune response (type I interferon) in the nose, rather than testing for each virus separately. Researchers will collect samples from over 1,100 older adults in geriatr…

This study tests whether a special PET scan using [18F]FET can better locate tiny pituitary tumors that cause Cushing's disease. Standard MRI scans miss these small tumors in about 30% of cases. The study will enroll 20 adults with Cushing's disease to see if the PET scan improve…

This study aims to develop a simple, non-invasive brain imaging technique using light (fNIRS) to measure brain function in people with Fragile X Syndrome and Creatine Transporter Deficiency. Researchers will test if this method can detect unique brain activity patterns that could…

This study is testing a new technology called optical biopsy (Cellvizio) that lets doctors see tissues in real-time during gynecological surgery without cutting them out. The goal is to see if this non-invasive method can accurately diagnose conditions like endometriosis or cance…

This study checks if a combined test on a simple blotting paper (like a dried blood spot) can accurately detect type 1 diabetes in children. Researchers will compare results from the blotting paper test with standard blood tests in 106 children newly diagnosed with diabetes. If s…

This study aims to validate new blood markers that can quickly rule out serious infection in newborns, helping doctors avoid giving unnecessary antibiotics. About 358 babies in intensive care with signs of late-onset sepsis will be tested. If successful, these markers could reduc…

This study tests whether a special risk score (the Lyon-VTE-score) can help doctors decide which pregnant women need blood thinners to prevent dangerous clots. About 600 pregnant women at high risk will be randomly assigned to either score-guided care or standard care. The goal i…

This study tests a new training program for general practitioners in France to help them talk with patients about healthy eating, physical activity, and reducing sitting time. The goal is to prevent chronic diseases like cancer and obesity. About 882 adults who are not yet ready …

This study tests whether a mobile van with a CT scanner and nurses can help more high-risk smokers get screened for lung cancer compared to going to a hospital. It aims to reach people who are socially disadvantaged and less likely to participate in traditional screening. About 4…

This study tests EXL01, a capsule containing a single beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two or three C. diff episodes will take…

This study tests whether baclofen, a muscle relaxant, can help people dependent on benzodiazepines (a type of sedative) lower their dose more easily. About 93 adults aged 18 to 65 with benzodiazepine use disorder will receive either baclofen or a placebo. The goal is to see if ba…

This study tests a new way to treat nerve pain that doesn't respond to medication. It uses a non-invasive technique called tACS that delivers a gentle electric current to the brain at a frequency matching the patient's own brain waves. The goal is to see if this personalized appr…

This study is testing a new tool called BougieCap™ to treat short, non-cancerous narrowings in the esophagus (the tube that carries food to the stomach). The device is a clear cap attached to a camera tube, allowing doctors to see and stretch the narrowing at the same time. About…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which corrects irregular heartbeats. About 200 children aged 5 to 17 who need this treatment will fill out questionnaires about their physical, emotional, social, and school…

This study follows 444 women who had Essure contraceptive implants removed due to symptoms like pain or allergic reactions. Researchers will track how much symptoms improve over time using patient surveys. The goal is to better understand why symptoms occur and improve surgical t…

This study tests whether a 12-week home telerehabilitation program using the MindMotion GO device can help stroke patients improve motor skills. It involves 51 adults who had a stroke more than 30 days ago and still have arm or leg weakness. The program provides 300 minutes of we…

This study tests a virtual reality training program (KidTrain) designed to help children aged 7–17 with bilateral cochlear implants improve their ability to locate sounds and understand speech in noisy environments. The program uses immersive audio and visual cues to simulate rea…

This study tests a manual technique called cutaneous resonance stimulation (RESC) to reduce anxiety in 62 people awaiting heart surgery. Participants will receive either real RESC or a fake version, and researchers will measure changes in stress-related body signals like heart ra…

This study tests whether starting intensive, machine-assisted breathing exercises early can improve cough strength in ICU patients with muscle weakness. About 50 adults on breathing machines who have failed a weaning test will receive either standard care or extra respiratory phy…

This study looks at two methods of removing a bladder catheter after urological surgery in 160 men. In the usual method, a nurse actively pulls the catheter out. In the new method, the catheter is allowed to fall out on its own (passive removal). The goal is to see which method m…

This study looks at whether hypnosis can help reduce anxiety in adults recently diagnosed with certain blood cancers (like lymphoma). Fifty participants will receive hypnosis sessions, and researchers will measure their anxiety levels before and after treatment. The goal is to se…

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover muscle strength, mobility, and reduce pain after hip fracture surgery. About 25 participants will receive vibration sessions five times a week for four wee…

This study tests whether a special MRI technique can show the exact position of cranial nerves near skull base tumors before surgery. Researchers will compare the nerve location seen on MRI with what they find during the actual operation. The goal is to help surgeons protect thes…

This study looks at whether a special diet that promotes a healthy mix of gut bacteria can improve weight loss and eating habits after bariatric surgery. About 60 adults who are having weight-loss surgery will be split into two groups: one gets standard nutrition advice, the othe…

This study aims to understand why some people with fatty liver disease develop a more serious form called NASH, which can lead to liver damage and cancer. Researchers will collect liver cells from 60 adults using a special needle and analyze them with advanced techniques. The goa…

This study looks at whether a shorter, more convenient urine collection (8 hours) can give the same information as the standard 24-hour collection for people with Wilson disease. Wilson disease causes copper buildup in the body, and doctors monitor treatment by measuring copper i…

This study aims to collect blood and spinal fluid samples from 350 people with conditions like Parkinson's disease, ALS, glioblastoma, certain cancers, and rheumatoid arthritis. The goal is to find new genetic markers that could help doctors diagnose autoimmune encephalitis and p…

This study aims to see if special brain recordings taken during thinking tasks can predict memory or attention problems after epilepsy surgery. About 50 adults with drug-resistant epilepsy who are already scheduled for brain-mapping surgery will participate. Researchers will comp…

This study looks at how healthy adults use rhythm and timing to understand speech and other sounds. Researchers will use brain scans (EEG and MEG) and behavioral tests to measure brain activity. The goal is to learn more about how we predict when sounds will happen, which could h…

This study looks at 80 people with lung fibrosis who also develop a serious lung blood pressure condition. Researchers will test blood and urine before and during treatment to find chemical markers that show who benefits and who doesn't. The goal is to better understand how the t…

This study looks at whether a program that pairs new mothers facing severe poverty with trained volunteer moms can help them breastfeed. About 50 mothers at a French hospital will get support from a peer mentor. The goal is to see if the program is practical and well-received, no…

This study looks at men who have a penile prosthesis for erectile dysfunction. Many patients find the pump hard to use, which can lead to less satisfaction. Researchers will measure hand strength, touch sensitivity, and how well patients can work the pump. The goal is to understa…

This study looks at people with creatine transporter deficiency, a rare genetic condition that causes intellectual disability, seizures, and movement problems. Researchers want to find the best tests to measure symptoms, since many standard tests are too hard for these patients. …

This study is a national registry that follows 1,500 women with multiple sclerosis (MS) or related conditions during pregnancy and after childbirth, along with their children. Researchers aim to learn how the disease and medications impact pregnancy, breastfeeding, and long-term …

This study looks at tongue muscle function in children with suspected obstructive sleep apnea (OSA). Researchers will measure tongue pressure and movement in 78 children referred for sleep testing and compare them to healthy children. The goal is to identify muscle deficits that …

This study is creating a large collection of blood samples from 1,000 people with atrial fibrillation (an irregular heartbeat) and stroke. Researchers will analyze the DNA and plasma to better understand the genetic causes linking these conditions. The goal is to find new targets…

This study looks at whether changes in sleep can act as an early warning sign for a flare-up in people with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Researchers will track sleep quality and disease activity in 216 adults who are currently i…

This study follows 500 adults aged 40–80 with type 2 diabetes and fatty liver disease to see if simple, non-invasive tests (like blood markers and liver stiffness scans) can predict which patients will develop serious liver scarring or cirrhosis. Researchers will track participan…

This study looks at 20 adults having weight-loss surgery to understand how a breakdown in communication between parts of liver cells might lead to MASH, a serious liver condition. Researchers will take small liver samples during surgery and blood tests before and after to track t…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain circuits be…

This study is creating a large collection of blood samples and health information from 3500 people with hepatitis B. Researchers will use these samples to measure and study viral RNAs, hoping to find a new way to tell if someone is functionally cured. No new treatments are tested…

This study looks at how having one leg shorter than the other affects the hips and lower back in children aged 10 to 15. Researchers will use special X-rays and force-measuring platforms to calculate joint pressures. The goal is to better understand these effects and help doctors…

This study looks at memory, thinking, and mood problems that can happen with certain targeted drugs for lung cancer. Researchers will work with 20 patients to better understand these side effects and how they affect daily life. The goal is to create a care plan that helps patient…

This study is testing several advanced imaging techniques to see if they can better predict which people with carotid artery narrowing are at risk for a stroke. Researchers will compare 45 people who have had a stroke with 105 who have not, all with at least 50% carotid stenosis.…

This study looks at how often there is a meaningful difference in blood pressure measured at the arm (radial artery) versus the leg (femoral artery) in people with shock. About 180 adults on strong blood-pressure-raising medicines will be checked. The goal is to learn how common …

This study looks at bone cells from children (ages 4 months to 18 years) who need surgery for craniosynostosis, a condition where skull bones fuse too early. Researchers want to see how burosumab and vitamin D directly affect these cells, especially in kids with hypophosphatemic …

This study looks at how iron deficiency and iron supplements impact the immune system in people with Hereditary Haemorrhagic Telangiectasia (HHT), a rare genetic condition that causes frequent nosebleeds and anemia. Researchers will measure immune cells in 155 adults with HHT to …

This study follows 60 children with spinal muscular atrophy (SMA) who are already receiving SMN-restoring therapies like nusinersen or gene therapy. Researchers want to describe the new disease patterns that emerge with these treatments and find better ways to monitor progress. T…

This study aims to better understand brain activity when people imagine moving their wrists, which could lead to improved rehabilitation therapies for stroke survivors with arm weakness. Researchers will use advanced brain imaging (MEG and EEG) to decode movement-related signals …

This study looks at 250 critically ill adults to see if a continuous finger sensor (perfusion index) can replace the manual capillary refill time test, where doctors press on the skin and time color return. The goal is to find a faster, automatic way to monitor blood flow without…

This study looks at why the hepatitis B virus (HBV) stays in the liver for so long, even with treatment. Researchers will use a gentle needle method (fine needle aspiration) to take small liver samples from 100 adults with chronic HBV. The goal is to learn how the virus and the i…

This study watches how the immune system changes over time in 200 adults with COVID-19 who are in the intensive care unit. Researchers take blood samples to measure immune markers and see how they relate to severe lung problems, infections, or death. No new treatments are given—t…

This study looks at whether a simple ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. About 55 adults aged 18-74 with certain cancers will have an ultrasound and a standard DEXA scan to compare results. The goal is t…

This study looks at patients on a heart-lung machine (ECMO) who also need kidney dialysis. It compares two ways to connect the dialysis machine: directly into the ECMO circuit or using a separate line. The goal is to see which method keeps the dialysis filter working longer and c…

This study aims to collect information from about 3,360 children in private healthcare who show signs of early or advanced puberty. Researchers want to understand why puberty is starting earlier and track patterns across France. The goal is to gather reliable data to help doctors…

This study looks at how a part of the brain called the posterior parietal cortex helps us combine vision and body position to reach for objects. Researchers will compare people with optic ataxia (a condition that affects reaching) and healthy volunteers using simple behavioral te…

This study looks at bacteria living in the liver, blood, and stool of people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this seri…

This study looks at whether women who had more estrogen exposure (from birth control, hormone therapy, pregnancy, or early puberty) before being diagnosed with a prolactinoma are more likely to develop a large tumor (macroadenoma) versus a small one (microadenoma). Researchers wi…

This study looks at how children with epilepsy learn things without trying, like picking up new skills or habits. Researchers will compare 40 children with epilepsy to healthy children using a simple computer task. The goal is to see if this type of learning is affected by epilep…

This study looks at whether certain people have antibodies that block their own immune system's first line of defense against viruses. Researchers will measure viral levels in nose samples from 360 adults and children in intensive care with severe flu, RSV, or COVID-19. The goal …

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study looks at why people with Developmental Coordination Disorder (DCD) have trouble with movement and coordination. Researchers will test touch and body-position senses in 280 children and adults to see if these sensory problems are a root cause. The goal is to better unde…

This study looks at the help that family members and friends give to people with Alzheimer's disease. Researchers want to understand how this care changes as the disease gets worse and what it costs. About 312 people aged 60 and older with Alzheimer's, along with their caregivers…

This study is looking at whether a blood test measuring mHLA-DR can help predict severe complications after pancreatic surgery. The researchers will follow 100 adults who are having this surgery to see if low mHLA-DR levels are linked to problems like infection or organ failure. …

This study uses a non-invasive monitoring technique called electrical impedance tomography (EIT) to see how air is distributed in the lungs of children with acute respiratory failure in the pediatric intensive care unit (PICU). Researchers will observe how changes in ventilator s…

This study uses special MRI scans to measure how well a donated kidney works in the recipient and how the donor's remaining kidney adapts. Researchers will follow 60 people (donors and recipients) for one year after transplant. The goal is to find better ways to select kidneys fr…

This study looks at how much adults with cystic fibrosis move and sit each day. Researchers want to understand activity patterns, especially in those taking newer CF drugs. The goal is to find patients who are very inactive and may need extra support to stay healthy. Around 270 a…

This study tests a new digital tool called Lianeli that helps doctors and patients work together to decide which health screenings (like cancer or diabetes checks) are right for the patient. The goal is to see if the tool is practical and easy to use in everyday doctor visits. Ab…

This study explores how the COVID-19 pandemic and related social restrictions (like lockdowns) influenced suicidal thoughts and actions in children and adolescents aged 8 to 17 in the Auvergne-Rhône-Alpes region of France. Researchers will collect data from up to 6,500 participan…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will record how babies suck on a pacifier and compare it to sleep test results. The goal is to find a simple, …

This study aims to create a simple tool to measure food preferences in patients over 70 in geriatric wards. Swallowing problems can lead to poor nutrition, so understanding what foods patients like may help improve their diets. Researchers will test the tool's reliability and exp…

This study aims to establish normal levels of immune markers called interferons in healthy adults aged 80 and older. By measuring these markers in the nose and blood, researchers hope to improve the diagnosis of active viral infections, which are often missed in older people. The…

This study collects blood samples from 400 children and their relatives to find genetic and immune system abnormalities in rare autoimmune and autoinflammatory diseases like lupus. The goal is to create a biological sample bank for future research. No treatments or interventions …

This study aims to learn more about a rare nerve condition called IgM-anti-MAG peripheral neuropathy, which causes numbness and weakness. Researchers will collect detailed information from 45 patients to identify different types of the disease and how they respond to treatment. T…

This study looks at how the cystic fibrosis drug Kaftrio (elexacaftor-tezacaftor-ivacaftor) behaves in children aged 2 to 17. Researchers will measure drug levels in the blood and check for side effects like liver problems or mood changes. The goal is to make the drug safer and m…

This study looks at how breathing and waking from sleep are connected in people with drug-resistant epilepsy. Researchers will measure carbon dioxide levels and breathing responses during deep sleep in 60 participants (30 with epilepsy and 30 healthy volunteers). The goal is to b…

This study compares two advanced brain-mapping techniques—MEG and high-resolution EEG—to see which better pinpoints the exact area causing seizures in people with drug-resistant epilepsy who are candidates for surgery. One hundred participants will undergo both scans before their…

This study looks at how often people with active Crohn's disease have a problem called exocrine pancreatic insufficiency (EPI), where the pancreas doesn't make enough enzymes to digest food properly. Researchers will check 50 adults before and 14 weeks after they start a biologic…

This study looks at how certain substances in the blood (nucleosomes and CTCF) change after surgery to remove colorectal cancer that has spread to the abdomen. The goal is to find a better way to tell if any cancer cells remain after the operation. About 58 adults having surgery …

This study aims to create a realistic model of the endometrium (the lining of the uterus) using tissue from 90 women with and without endometriosis. The goal is to test how well different hormone treatments work on each person's tissue, so doctors can choose the best therapy with…

This study enrolls 500 adults who had an ischemic stroke and are eligible for clot-busting treatment or clot removal. Researchers will collect medical images, blood samples, and health data to discover new biological and imaging markers that can predict recovery and heart complic…

This study follows 400 pregnant women with rare blood vessel disorders (like HHT, Marfan syndrome, or lymphedema) to learn about complications during and after pregnancy. Researchers will collect data via phone questionnaires over 12 months. The goal is to improve medical recomme…

This study aims to create a reliable lab test to monitor anti-TFPI antibodies, a new type of treatment for hemophilia. Researchers will test blood samples from 11 men with severe hemophilia who are already taking the anti-TFPI drug Marstacimab. The goal is to better measure how w…

This study tests whether teaching parents practical tips can reduce the amount of endocrine-disrupting chemicals (found in plastics and personal care products) in their babies' urine. About 90 healthy newborns will be randomly assigned to receive either standard care or hands-on …

This study follows 300 adults who have had a severe type of heart attack (STEMI) to discover new biological and imaging markers that can predict heart function and recovery. Researchers will collect blood samples and perform MRI scans over one year, and track patients' health for…

This study looks at how the autonomic nervous system (which controls automatic body functions) might be linked to liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis to find new ways to detect liver cancer earlier. The goal …

This study looks at how thick the blood is in 160 adults with polycythemia, a condition where the body makes too many red blood cells. Researchers want to see if thicker blood causes more problems like clots or headaches. They are not testing any new treatments, just measuring bl…

This study tests a new imaging technique called electrical impedance tomography (EIT) to measure how air and blood flow in the lungs of children with acute breathing failure. The researchers will inject a small, weight-adjusted amount of salt solution to see if it safely and effe…

This study looks at muscle loss (sarcopenia) and cognitive problems (chemobrain) in people who have finished cancer treatment. Researchers will collect data from 100 adults aged 18-74 with certain cancers to see how common these issues are. The goal is to better understand and ma…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. The idea is that the brain changes that happen during motor learning might also help with language functions that use the same brain areas. The study wi…

This study looks at how the body's automatic nervous system changes when ICU patients receive continuous kidney therapy to remove extra fluid. Researchers will use a special index (ANI) to measure nerve activity and see if it relates to changes in blood pressure. The goal is to b…

This study looks at how attention helps the brain stop unwanted actions or thoughts. Researchers will test 120 people, including healthy volunteers and patients with conditions like ADHD or stroke-related attention issues. The goal is to better understand these brain processes to…

This study tests whether small wearable sensors can safely track movement and walking in pregnant women during early labor while they have a low-dose epidural. Researchers will measure how gait changes with pain and medication. The goal is to improve monitoring, prevent falls, an…

This study looks at how blind people use a white cane not just to move around, but to sense the world. Researchers will measure where people feel a touch on the cane and track brain activity with EEG and MRI. The goal is to understand how the cane becomes an extension of the body…

This study looks at whether a special MRI scan (T1 mapping) can help doctors see kidney damage in people with Fabry disease. Researchers will compare MRI results from 70 adults with and without Fabry disease. The goal is to improve how doctors diagnose and monitor kidney problems…

This study follows 3,000 adult cancer patients who take oral anticancer drugs at home. Researchers want to understand how well these drugs work in real life and identify any problems, like side effects or dosing issues. The goal is to improve patient care and safety through bette…

This study aims to find biological markers (signs in the blood) that can identify which patients with aortic stenosis are at higher risk of heart problems. Researchers will collect blood samples and health information from 125 patients with different stages of aortic stenosis. Th…

This study tests whether virtual reality and mental imagery can replace traditional prism adaptation therapy for people with unilateral neglect after a brain injury. Researchers will first work with 480 healthy volunteers to see if these new methods work similarly to the standard…

This study is observing 150 adults with long-COVID (symptoms lasting over 4 weeks) to group them by their symptoms and link those groups to lab results. The goal is to find patterns that could help predict outcomes and point to new treatments. Participants will provide medical da…

This study looks at how women aged 70 and older with advanced ovarian cancer handle a type of drug called PARP inhibitors. These drugs can cause side effects like low blood counts, which may be more common in older patients. The goal is to find out which factors affect how much o…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can prevent drug-related problems. TRT uses radioactive drugs to kill cancer cells while sparing healthy tissue. The study will inc…

This study looks at how different types of glaucoma surgery affect patients' quality of life, not just eye pressure. About 132 adults having surgery will fill out questionnaires before and 6 months after their operation. The goal is to understand what matters most to patients, in…

This study is creating a large database of blood samples, tumor tissue, and medical images from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to collect information that can be used for future studies. The goal is to better understand lung…

This study watches how the body's natural daily rhythms (circadian cycles) change as people wake up from a coma after a severe brain injury. Researchers will monitor 90 intensive care patients using behavioral and brain tests to see if these rhythms signal recovery. The goal is t…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…

This study aims to create a faster, simpler tool called the SBS Disk to measure quality of life in people with short bowel syndrome. Researchers will compare it to a longer existing questionnaire. About 100 adults who can read French and have short bowel syndrome will take part. …

This study looks at the long-term social and emotional well-being of people who had NMDA receptor encephalitis, a rare brain disease. Researchers will use questionnaires to measure fatigue, anxiety, depression, sleep, and quality of life in 30 adults who are at least 18 years old…

This study aims to collect and store biological samples (like tumor tissue or blood) from 500 adults with confirmed brain tumors. The samples will be used for future research to better understand brain tumors. No treatment or experimental therapy is given—this is purely a sample …

This study follows 70 adults with a type of blood cancer (diffuse large B-cell lymphoma) who are receiving CAR-T cell therapy. Researchers want to understand how the treatment affects patients' quality of life and what medications they actually use in everyday care. The goal is t…

This study looks at whether people with CAPS (a rare genetic condition causing fever and inflammation) have disrupted daily body rhythms. Researchers will measure melatonin and other clock-related markers in 30 participants (15 with CAPS and 15 healthy household members). The goa…

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to understand the bacteria's role and how they change with standard treatment. The goal is to fin…