Hospices Civils De Lyon

This phase 3 trial tests whether focused high-intensity ultrasound (HIFU) can destroy low-risk prostate tumors without the side effects of radical treatments. Men aged 50-80 with a single, low-risk tumor will be randomly assigned to either HIFU or active surveillance (regular mon…

This phase 2 trial tests a combination of two immunotherapy drugs, domvanalimab and zimberelimab, in people with five types of advanced rare cancers (peritoneal mesothelioma, gestational trophoblastic tumor, anaplastic thyroid carcinoma, neuroendocrine tumors, and thymic carcinom…

This study aimed to see if the drug clomiphene citrate could help men with a condition called non-obstructive azoospermia, where the body produces little to no sperm. The plan was to give the drug or a placebo for nine months, then check if sperm could be found in the semen or th…

This study looks at whether a program of supervised exercise and nutrition advice can prevent older adults from losing their ability to move around. It includes 530 people aged 80 or older who are at risk of mobility problems. Participants get a personalized exercise plan and die…

This study looks at two methods to check blood flow in critically ill patients: the traditional capillary refill time (pressing on skin and timing color return) and the perfusion index (a continuous reading from a finger clip). Researchers want to see if the perfusion index can r…

This study looks at how dupilumab, a drug for severe asthma, is actually used by patients in France. Researchers will analyze health records of about 35,000 people to describe their characteristics, healthcare costs, and steroid use before and after starting the drug. The goal is…

This study is testing whether a computer tool called MEKANOS can better predict the risk of hip fractures in people with Fibrous Dysplasia or McCune-Albright Syndrome. Researchers will take CT scans of the femur and use the tool to calculate bone strength. The goal is to improve …

This study looks back at the medical records of 150 children treated for tuberculosis at a French hospital. The goal is to see how many were cured, how many had problems, and why some treatments failed. By understanding these patterns, doctors hope to improve care for children wi…

This study looks at how repeated seizures affect breathing and heart function in people with Dravet syndrome, a severe form of epilepsy. Researchers will monitor 92 children and adults for 24-48 hours using video, brain wave, heart, and breathing recordings. The goal is to find c…

This study tests whether having peer supporters trained in Mental Health First Aid (MHFA) can improve the mental well-being of first-year medical residents. About 520 residents in Lyon will be followed for a year, comparing those exposed to trained peers with those who are not. T…

This study looks at how well immunotherapy works in people with advanced lung or head and neck cancers. Researchers will take blood samples before and after treatment to measure how the body clears the drug and how tumor cells in the blood change. The goal is to find markers that…