Hospices Civils De Lyon

This study looked at how safe the drug cabozantinib is for people with advanced liver cancer (hepatocellular carcinoma) who have already tried another treatment called sorafenib. A total of 110 adults took part. The main goal was to track survival and any side effects that requir…

This study looked at whether the usual vitamin D supplement (cholecalciferol) helps children with chronic kidney disease, kidney transplants, or nephrotic syndrome reach healthy vitamin D levels. 43 children took a single high-dose vitamin D vial, and researchers checked their vi…

This study tested whether a special medical glue (IFABOND) can safely hold mesh in place during laparoscopic surgery for pelvic organ prolapse. The goal was to see if using glue instead of staples or stitches reduces complications like vaginal erosion. 70 women with advanced prol…

This study tested a technique where patients drink a special liquid (5-ALA) before brain surgery for glioblastoma, a fast-growing brain tumor. The liquid makes tumor cells glow under a special light, helping surgeons see and remove more of the cancer compared to using standard co…

This study tested whether naloxone, a drug that reverses opioid overdoses, can help people with epilepsy breathe better right after a seizure. About 485 adults with drug-resistant epilepsy were monitored in the hospital. If they had a seizure, they received either naloxone or a p…

This study looked at 279 people with idiopathic pulmonary fibrosis (IPF) whose disease was getting worse despite taking one of two approved drugs (pirfenidone or nintedanib). The goal was to see if combining both drugs works better than switching to the other drug alone. The tria…

This study looked at 141 men with Klinefelter syndrome (47,XXY) to see if younger men (ages 15–22) have a better chance of finding sperm through testicular biopsy compared to older men (ages 23–55). Participants provided two semen samples, and if no sperm were found, they had a b…

This study tested a treatment called therapeutic plasma exchange (TPE) for people with severe COVID-19. TPE filters the blood to remove harmful inflammatory substances that can cause breathing failure. The study compared standard intensive care alone to standard care plus TPE in …

This study tested whether minoxidil, a blood pressure medicine, could improve blood vessel health in children with Williams-Beuren syndrome. The condition causes heart and blood vessel problems due to a lack of a protein called elastin. Twenty-one children took minoxidil or a pla…

This study tested whether adding pegylated interferon to the standard drug nilotinib helps people with newly diagnosed chronic myeloid leukemia (CML) achieve a deeper molecular response. About 200 adults under 65 took either nilotinib alone or nilotinib plus the added drug for up…

This study tested whether adding bevacizumab to standard chemotherapy (Folfiri) helps people with advanced, aggressive neuroendocrine cancer live longer after their first treatment stops working. 153 adults with this rare cancer took part. The main goal was to see how many were s…

This study tested a special heart-protection plan given during heart surgery to see if it could reduce heart muscle damage compared to usual care. 210 adults having aortic valve surgery took part across multiple French hospitals. Researchers measured a heart damage marker in the …

This study tested a device called MitraClip, which clips a leaky heart valve, in 304 people with severe mitral regurgitation and heart failure. Participants either got standard care alone or standard care plus the clip procedure. The goal was to see if the clip could lower deaths…

This study looked at two ways to treat unruptured brain aneurysms (bulging blood vessels) that haven't bled yet. One method uses tiny coils to block the aneurysm, while the newer approach uses a special stent to divert blood flow away from it. Researchers compared how well each m…

This study tested a highly targeted radiation therapy (stereotactic radiotherapy) for small kidney cancers (4 cm or less). The goal was to find the safest high dose that can destroy the tumor while protecting healthy tissue. Thirteen patients were treated with different radiation…

This study tested a treatment for cancer that has spread inside the abdomen (peritoneal carcinosis). It combined surgery to remove visible tumors with heated chemotherapy drugs (mitomycin C and irinotecan) pumped directly into the abdomen during the operation. The goal was to fin…

This study tested whether regular phone calls and monthly visits with a nurse could help teenagers with type 1 diabetes feel more in control and improve their blood sugar levels. 77 teens aged 13-18 with poorly controlled diabetes took part. The nurse counseling group received ex…

This study looked at 140 people aged 18 to 45 who had surgery to fix a dislocating kneecap. The surgery repaired a key knee ligament (MPFL). Half also got an extra release of a tight band on the outer knee. The goal was to see if the extra step improved kneecap tilt or caused mor…

This study tested a focused ultrasound (HIFU) treatment for men with intermediate-risk prostate cancer that has not spread. The goal was to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. 174 …

This study looked at 78 adults with advanced kidney failure who needed surgery to create a blood vessel connection (fistula) for dialysis. Researchers compared two ways to numb the arm during surgery: a local injection versus a nerve block near the armpit. The goal was to see if …

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse harmful DNA changes in heart cells, reducing scarring and improving heart rhythm. Only one person took p…

This study looked at whether a drug called everolimus can help prevent new skin cancers in people who have had a heart transplant. 175 heart transplant patients with a history of skin cancer took part. The goal was to see if switching to everolimus reduced the number of new skin …

This study tested a technique called remote ischemic conditioning in 180 adults with septic shock. The treatment involves briefly inflating a blood pressure cuff on the arm to protect organs from damage. The goal was to see if this simple, non-drug approach could limit the severi…

This study tested a new approach for advanced ovarian cancer: giving the immunotherapy drug nivolumab directly into the abdomen (intraperitoneally) after surgery and heated chemotherapy (HIPEC). The goal was to see if this combination is safe and tolerable. Twenty-two adults with…

This study compares two types of weight-loss surgery for people with severe obesity: a newer procedure called SADI-S and the standard RYGB. About 382 adults will be randomly assigned to one surgery and followed for 2 years to see which leads to greater weight loss and fewer compl…

This study tested whether a drug called somatostatin can prevent fluid buildup in the belly after liver cancer surgery. About 179 patients took part. The goal was to see if the drug lowers the risk of complications and shortens hospital stays.

This study tested whether a combination of two chemotherapy drugs (clofarabine and intermediate-dose cytarabine, called CLARA) works better than high-dose cytarabine alone (HDAC) to keep acute myeloid leukemia (AML) from coming back after initial treatment. It included 735 younge…

This study tested a method to keep fluid levels neutral in 65 critically ill patients with acute kidney injury who were on a type of dialysis. The approach used advanced heart monitoring to safely match fluid removal to fluid intake. The goal was to see if this could reduce compl…

This study compared two treatments for people with Barrett's esophagus who have high-grade dysplasia, a precancerous condition. One treatment is surgery to remove part of the esophagus, which has high risks. The other is a newer, less invasive procedure using a balloon that deliv…

This study compared two ways to perform partial knee replacement surgery for people with knee osteoarthritis: using a robotic system (Navio) versus the traditional manual method. Sixty-six adults with inner knee arthritis were randomly assigned to one of the two techniques. The g…

This study tested a combination of three drugs (cyclophosphamide, metformin, and olaparib) in 35 women with recurrent advanced or metastatic endometrial cancer that had already been treated with chemotherapy. The goal was to find a safe dose and see if the combination could stop …

This study tested a new device called Lina Librata that uses a balloon to destroy the lining of the uterus, reducing heavy menstrual bleeding. It involved 38 women aged 40-50 who did not want future pregnancies. The goal was to see if the procedure could be done with local anesth…

This study tested if placing patients with severe acute respiratory distress syndrome (ARDS) on their stomachs (prone position) for at least 16 hours a day could lower the chance of dying. 474 adults on breathing machines were randomly assigned to lie face down or stay on their b…

This study tested whether methotrexate works as well as cyclosporine for adults with moderate to severe eczema. About 100 participants received one of the two drugs for 24 weeks. The goal was to see how many people had a 50% improvement in their eczema symptoms after 8 weeks.

This study looked at people with rectal cancer that has spread to other parts of the body and cannot be fully removed. It compared having surgery to remove the main tumor followed by chemotherapy, versus having chemotherapy alone. The goal was to see which approach helps patients…

This study tested a method called HOPE, which gently pumps oxygenated cold fluid through donor livers before transplant. It included 266 adults receiving a liver from an older or higher-risk donor. The goal was to see if HOPE reduces early liver problems after surgery compared to…

This study tested a drug called avelumab in 24 women with a rare pregnancy-related cancer (GTN) that did not respond to standard chemotherapy. The goal was to see if the drug could lower their tumor marker (hCG) to normal levels and allow them to stop treatment. Avelumab works by…

This study looked at whether using a specially sized (calibrated) interdental brush is better than a regular one for keeping gums healthy in young adults aged 18 to 30. Over three months, 51 participants used either a calibrated or non-calibrated brush daily. The main goal was to…

This study tested hand transplants in 7 people who lost both forearms. The goal was to see if the brain can adapt to the new hands and improve daily life. Participants had to be between 20 and 40 years old and had to have had their amputation 3 months to 3 years before the transp…

This study looked at 77 kidney transplant recipients who had already developed a first skin cancer (squamous cell carcinoma). Researchers wanted to see if switching their anti-rejection medication from calcineurin inhibitors to rapamycin would lower the chance of getting new skin…

This study tested a new way of using breathing machines for COVID-19 patients with severe lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. About 220 adults on ventil…

This study tested whether giving growth hormone to children with short bowel syndrome could help them reduce or stop needing nutrition through an IV. Fourteen children aged 3 to 18 who had been on IV nutrition for at least 3 years took part. Some received growth hormone for 4 mon…

This study tested a computer-controlled system that automatically gives fluids during high-risk abdominal surgery to keep the heart pumping efficiently. 46 adults having major abdominal surgery were randomly assigned to either the automated system or standard care by the anesthes…

This study compared two types of weight-loss surgery—Omega Loop Bypass and Roux-en-Y Gastric Bypass—in 256 adults with severe obesity. The goal was to see which surgery works better for weight loss and has fewer complications. Both surgeries aim to help people lose weight and imp…

This study tested whether a second stem cell transplant from a matched donor could help younger myeloma patients (under 65) who had a good response to their first transplant. Thirteen patients received a reduced-intensity conditioning regimen followed by donor stem cells. The goa…

This study tested whether a 6-month personalized home walking program could reduce bleeding inside carotid artery plaques in 56 patients with significant but symptom-free blockages. Participants wore activity trackers and aimed for 6,000 steps daily. The goal was to see if exerci…

This study tested a device called Cavaterm™ that uses a balloon to remove the lining of the womb in women with heavy menstrual bleeding (menometrorrhagia) who no longer wish to have children. The goal was to see if the treatment reduces bleeding after 2 months. The study included…

This study compared two types of albumin dialysis (MARS and SPAD) in 34 people with severe liver failure. Both treatments filter toxins from the blood when the liver cannot. The goal was to see which one removes bilirubin better and is easier to use. Results help doctors choose t…

This study tested whether eating foods with extra fiber, polyphenols, omega-3, and slow-digesting starch for 9 weeks could reduce low-grade inflammation in 62 adults with abdominal obesity and cardiometabolic risk. Participants ate either fortified or standard foods, and research…

This study looked at 346 kidney transplant patients to see if a biopsy taken 3 months after surgery could help doctors better manage anti-rejection drugs. Patients with mild signs of rejection were given extra treatment, while those with no inflammation had their steroids reduced…

This study tested whether a gentle brain stimulation technique called tDCS can help people with schizophrenia whose symptoms don't fully improve with medication alone. 141 participants received either real or fake (placebo) stimulation over 5 days. The goal was to see if the real…

This study tested two different chemotherapy combinations (R-ACVBP and R-CHOP) along with the targeted drug rituximab in 222 adults aged 18-59 with an aggressive type of B-cell lymphoma. Participants had 2 or 3 risk factors that make the disease harder to treat. The researchers u…

This study tested a new way to place dental implants in the upper jaw when there isn't much bone. Instead of doing a sinus lift (a common bone-building surgery), doctors used a special image-guided system to place implants more precisely. The study included 60 adults who needed i…

This study tested whether a single injection of cyclosporine, given right before opening a blocked artery, could improve outcomes for people having a major heart attack. About 970 patients received either cyclosporine or a placebo. Researchers tracked deaths, hospitalizations for…

This study tested a drug called bevacizumab in 25 adults with hereditary hemorrhagic telangiectasia (HHT) who had severe liver blood vessel problems and high cardiac output. The goal was to see if the drug could improve heart function and avoid the need for a liver transplant, wh…

This study tested the drug olaparib in 35 adults with a specific type of aggressive brain tumor (IDH-mutant high-grade glioma) that had returned after standard treatments. The drug works by taking advantage of a weakness in the tumor cells' ability to repair their DNA. The main g…

This study looked at 120 women over 70 with advanced ovarian cancer who were considered vulnerable due to age and health. It compared three chemotherapy plans: standard two-drug therapy, a single drug, or a weekly low-dose combination. The goal was to see which plan allowed patie…

This study tested whether a drug called GM-CSF can reduce new infections in ICU patients whose immune system is weakened after severe sepsis or septic shock. 166 adults were randomly given either GM-CSF or a placebo. The goal was to see if the drug could lower the number of hospi…

This study tested whether a simple, non-invasive ultrasound can accurately detect when a child's stomach contains too much fluid, which can be dangerous during anesthesia. Researchers gave 92 healthy children different amounts of clear liquid to drink, then used ultrasound to che…

This study tested whether using MRI to guide prostate biopsies finds more aggressive cancers than the usual method of taking random samples. 275 men with suspected prostate cancer each received both standard and MRI-targeted biopsies. The goal was to see if the MRI approach detec…

This study looked at whether an ultra-low dose CT scan can spot lung blood vessel malformations (PAVMs) in people with HHT as well as a standard low-dose CT scan, but with far less radiation. 45 patients with HHT had both scans, and researchers compared how often each correctly f…

This study looked at whether ultrasound can accurately detect a full stomach in patients lying flat versus sitting up at a 45-degree angle. The goal is to improve safety before anesthesia by better identifying those at risk for a rare but serious complication where stomach conten…

This study tested a new way to diagnose partial tears of the anterior cruciate ligament (ACL) in the knee. Standard MRI scans can miss these tears, so researchers added a measurement of knee looseness (laxity) during the scan. 151 people with knee injuries were enrolled and follo…

This study tested a special microscope called Cellvizio® to look at the fallopian tubes during keyhole surgery. The goal was to see if it could find early, pre-cancerous changes that might lead to ovarian cancer. 40 women having their fallopian tubes removed for various reasons t…

This study looked at whether a detailed swallowing test (high-resolution manometry) can find the cause of swallowing problems when a standard scope shows nothing wrong. 247 adults with unexplained trouble swallowing took part. The goal was to see if this test gives a clearer diag…

This study tested whether two advanced imaging techniques, Histoscanning and multiparametric MRI, can more accurately detect and locate prostate cancer that returns after radiation therapy. Thirty men with signs of recurrence underwent both scans, followed by targeted and random …

This study looked at whether measuring a substance called BD glucan in the belly fluid of ICU patients with peritonitis can diagnose fungal infections faster than standard lab tests. Standard tests can take days, but this new method might give results sooner, allowing earlier tre…

This study tested if a simple, painless eye ultrasound can detect high pressure inside the skull (intracranial hypertension) in children. High brain pressure is a serious risk after head injury or certain infections, and current monitoring requires inserting a tube or sensor into…

This study tested whether a standardized, step-by-step diagnostic plan for uveitis (eye inflammation) works as well as letting doctors choose tests freely, while costing less. Over 900 adults with uveitis took part. The goal was to see if the standardized approach could find the …

This study looked at 7 different blood markers to see if they can better tell apart severe bacterial infections from viral infections in young children with fever. About 983 children aged 7 days to 36 months participated. The goal is to find a combination of markers that works be…

This study tested whether a special type of PET/MRI scan can better find tiny pituitary tumors that cause Cushing's disease. Standard MRI misses these tumors in about 40% of patients, leading to more invasive tests. The study involved 33 adults with confirmed Cushing's disease an…

This study tested a new device called DiCART that automatically measures how quickly blood returns to the skin after pressing it (capillary refill time). Doctors use this test to check blood flow in emergencies, but manual measurements can vary. 20 healthy volunteers had blood fl…

This study tested whether a cone-beam CT scanner (often used for dental imaging) can detect and classify fractures in the arms and legs as accurately as a standard CT scanner. 43 adults with suspected fractures received both scans, and doctors compared the results. The goal was t…

This study looked for the best combination of blood tests to quickly and accurately diagnose late-onset sepsis in newborns in the NICU. Sepsis is hard to diagnose in babies, leading to too many antibiotics. Researchers tested 233 infants to find a biomarker mix that could rule ou…

This study tested whether a cone-beam CT scanner (often used for dental imaging) can detect cartilage damage in the wrist, ankle, elbow, and knee as well as a standard multidetector CT scanner. 69 adults who needed a joint scan with dye injection took part. Each person received b…

This study tested a special mouthguard (BRUXENSE splint) to see if it can help diagnose sleep bruxism (teeth grinding) accurately and easily. Seven adults with bruxism wore the device for 10 nights to check if it was comfortable and collected enough data. The goal is to create a …

This study tested whether quickly removing a small amount of fluid during dialysis can help predict if a patient needs more fluids. Twenty critically ill adults with acute kidney injury on continuous dialysis took part. Researchers compared two speeds of fluid removal to a standa…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage 8 common health problems (like pneumonia, kidney stones, and pregnancy concerns) without needing extra tests. Over 160 patients took part, and researchers compar…

This study tested a new tool that uses special light to help surgeons see brain tumors more clearly during surgery. Eleven adults with suspected brain tumors took part. The goal was to see if the tool could tell the difference between tumor types and healthy tissue, which could l…

This study tested two new tools to make tuberculosis (TB) skin tests better. Researchers compared a new, easy-to-use needle against the standard method and tried a non-invasive scanner to read the results. The goal was to see if these tools could make TB testing simpler and more …

This study tested whether a program combining exercise and education could help healthcare workers avoid repeat episodes of lower back pain. Over 350 hospital workers with a history of back pain took part, with some receiving the program and others usual care. The goal was to see…

This study looked at whether prazosin, a drug normally used for high blood pressure, can prevent post-traumatic stress disorder (PTSD) in people who recently experienced a traumatic event like an accident or assault. Researchers gave the drug to 15 adults who showed signs of acut…

This study tested a special nursing plan to prevent pressure sores (bedsores) in patients with severe lung failure who must lie face-down to help them breathe. The plan involved careful positioning and regular checks of at-risk areas like the forehead, chest, and knees. 160 adult…

This study tested a team-based program to prevent falls in elderly hospital patients. Over 1,800 people aged 65 and older took part. The program focused on identifying risks, preventing falls, and teaching patients how to get up safely. Researchers measured how many falls occurre…

This study tested a program to help women over 50 get proper care for osteoporosis after a low-impact wrist or upper arm fracture. Half of the women received extra information and reminders about osteoporosis, while the other half got usual care. The goal was to see if the progra…

This study tested whether giving the anti-seizure drug levetiracetam right after a brain bleed (hemorrhagic stroke) could prevent seizures and improve recovery. About 50 adults with a recent brain bleed were randomly assigned to receive levetiracetam or a placebo for 48 hours. Th…

This study looked at how long women with Factor V Leiden or Factor II mutations should take blood thinners after giving birth to prevent dangerous blood clots. Researchers compared treatment lasting less than 2 weeks versus 6 weeks in 86 women. The goal was to see if shorter trea…

This study tested a care pathway for adults over 70 who showed early signs of mobility trouble. Participants received personalized exercise coaching and nutritional counseling to prevent loss of mobility. The goal was to see if this approach could help them maintain strength, bal…

This study tested different doses of melatonin to see which one best improves sleep quality in autistic children aged 3 to 12 who have trouble sleeping. Researchers measured night awakenings, sleep onset, and total sleep time using sleep trackers and questionnaires. The goal was …

This study tested whether a short educational session before outpatient orthopedic surgery helps patients manage their pain better at home. About 412 adults scheduled for day surgery took part. The goal was to see if teaching patients about pain and how to use painkillers properl…

This study looked at whether regular cycling during dialysis sessions can improve blood flow to the legs in people with chronic kidney disease. 27 stable adult patients on long-term hemodialysis volunteered to cycle for 30 minutes each session over three months. The main goal was…

This study looked at how symptoms change after a Bulkamid injection for stress urinary incontinence in women. The treatment is a simple, outpatient procedure done under local anesthesia. It helps the urethra close better to reduce leakage. The study included 70 women who received…

This study looked for the best dose of ephedrine to treat low blood pressure during surgery in newborns and infants up to 6 months old. Low blood pressure is common under anesthesia and can be harmful. The study tested different doses to find one that works better than the standa…

This study tested two drugs, gabapentin and memantine, in 10 people with multiple sclerosis who have a constant, shaky eye movement called pendular nystagmus. The goal was to see if these drugs could reduce the eye shaking and improve vision and quality of life. Researchers measu…

This study looked at two methods to control pain after total knee replacement: a nerve block in the thigh (adductor channel block) and injecting numbing medicine around the knee joint (periarticular infiltration). The goal was to see which one reduces the need for morphine and he…

This study tested whether applying estrogen cream to the penis for two months before surgery could reduce healing problems in 244 boys with severe hypospadias, a birth defect where the urethra doesn't form properly. The goal was to see if it lowers the risk of post-surgery compli…

This study tested a temporary urethral stent in 9 men with a bladder-sphincter coordination problem caused by spinal cord injury. The stent was placed to help them empty their bladder more easily, as an alternative to more invasive surgery. The main goal was to see if patients fe…

This study looked at the safety of giving lidocaine (a numbing medicine) during weight-loss surgery. Fifty adults having laparoscopic bariatric surgery received lidocaine, and researchers measured its levels in the blood at several points and watched for side effects like seizure…

This study looked at whether bringing in a supportive and palliative care team early can improve quality of life for adults with acute leukemia that has come back for the first time. 49 participants were split into two groups: one received early, standardized supportive care, and…

This study looked at whether a one-year, supervised adaptive physical activity program can improve aerobic capacity, cardiovascular health, bone benefits, and quality of life in children and adolescents aged 6 to 18 with osteogenesis imperfecta (brittle bone disease). Thirty part…

This study tested whether placing infants under 6 months old with moderate to severe bronchiolitis on their stomachs (prone position) while on high-flow nasal cannula could reduce the need for more intensive breathing support like CPAP or a ventilator. Researchers compared this t…

This study compared two types of total knee replacements (fixed vs mobile bearing) in 160 patients with knee arthritis. The goal was to see which type gives better function and knee alignment. Participants were between 50 and 90 years old and had arthritis on the inner side of th…

This study tested a drug called tocilizumab for people with fibrous dysplasia of bone who still had pain after standard treatment. The drug blocks a protein linked to bone damage. Nineteen adults participated in this small, early-stage trial to see if the drug could reduce bone p…

This study looked at 27 children aged 6 to 11 with cystic fibrosis to see if a treatment called CFTR modulators (KAFTRIO) improves their nose and sinus symptoms and quality of life. The researchers measured changes using a special questionnaire (SN-5 scale) before and one year af…

This study looked at 250 people having total knee replacement to compare two ways of handling the kneecap: resurfacing it with a plastic implant or leaving the natural cartilage in place. The goal was to see which method leads to better knee function and comfort one year after su…

This study tested whether showing patients a live ultrasound image of their tongue during speech therapy helps them improve faster. It included 18 adults who had surgery for mouth or throat cancer and children with brain damage causing speech issues. Patients had standard therapy…

This study tested a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for people with chronic, severe tinnitus (ringing in the ears). 64 adults received either real or fake (sham) magnetic pulses to see if it could reduce their tinnitus symptoms. T…

This study tested if a simple ear acupuncture treatment could help lower anxiety in women waiting for a planned cesarean section. 91 women were given either a small needle patch, a needle-free patch, or no patch on their ear. The goal was to see if the acupuncture could calm nerv…

This study tested whether injecting botulinum toxin into two leg muscles (rectus femoris and semitendinosus) improves movement and reduces stiffness in children with cerebral palsy. Twenty-three children aged 7 to 17 who could walk participated. Researchers measured leg motion, s…

This study tested whether injecting botulinum toxin (like Botox) into the lower esophagus can relieve chest pain and swallowing difficulty in people with nutcracker esophagus, a condition where the esophagus contracts too strongly. Twenty-four adults with symptoms received either…

This study tested whether adding functional electrical stimulation (FES) to stationary cycling helps people who survived severe COVID-19 regain physical function faster. Twenty-two adults who had been on ventilators in the ICU took part. Researchers measured how much time patient…

This study tested two different ways to help people who had a stroke regain arm movement. One method used intentional, focused exercises, while the other aimed to stimulate more automatic, natural movements. Researchers enrolled 26 adults who had a stroke at least 6 weeks prior a…

This study tested whether adding sufentanil to ropivacaine in a nerve block reduces pain after video-assisted lung surgery better than ropivacaine alone. 90 adults scheduled for surgery took part. The main goal was to see if the combination lowered morphine use in the first 48 ho…

This study looked at whether foot reflexology (a type of foot massage) can help reduce nausea and vomiting caused by chemotherapy in people with lung or digestive cancer. About 80 adults took part. Researchers measured nausea levels before and after the reflexology session to see…

This study looked at two treatments for Osgood-Schlatter disease, a common cause of knee pain in growing teens who play sports. Researchers compared wearing a leg cast to simply resting from sports. The main goal was to see which approach helped more teens return to full sports a…

This study tested whether giving lidocaine through a vein during ear, nose, and throat cancer surgery can lower the need for strong painkillers (opioids) and reduce long-term pain. 143 adults having major head and neck cancer surgery were randomly assigned to receive either lidoc…

This study looked at whether doing handgrip exercises before and after surgery can improve the size and function of dialysis fistulas in people with advanced kidney disease. 40 patients participated, and the goal was to see if the exercises helped the fistula mature enough for ef…

This study tested a 5-month mindfulness meditation program for hospital workers to see if it could improve their mental health and job satisfaction. About 108 healthcare professionals took part, with some doing the meditation program and others serving as a control group. The goa…

This study followed 66 women with pelvic organ prolapse who had a surgery called anterior sacrospinofixation using their own tissue instead of mesh. The goal was to see if the surgery improved their symptoms like discomfort, urinary issues, or sexual problems. Researchers measure…

This study tested whether clonidine, a drug used for high blood pressure, can reduce impulse control disorders (like gambling or compulsive eating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The goal was to see if the d…

This small pilot study tested whether a device that gently stimulates a nerve in the ear (the vagus nerve) could help women with Irritable Bowel Syndrome (IBS). Ten to eighteen women used the device daily for six months. Researchers measured changes in symptoms, digestion, and qu…

This study tested a drug called pasireotide in 57 adults who had bowel surgery and a stoma (enterostomy) that produced too much fluid, even after standard treatments. The goal was to see if pasireotide could reduce the amount of fluid lost through the stoma within 72 hours, helpi…

This study tested whether wearing a special compression garment (a tight vest) can reduce shoulder pain and improve joint stability in people with hypermobility Ehlers-Danlos syndrome. About 48 adults wore the vest for 4 weeks and then went without it for 4 weeks, so researchers …

This study tested whether playing on an electronic tablet can reduce anxiety in children before outpatient surgery better than the standard medicine, midazolam. 118 children aged 4 to 10 were randomly assigned to receive either the tablet or the drug. Their anxiety levels were me…

This study tested if a non-invasive brain stimulation technique called tDCS can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 people, including both healthy volunteers and patients with long-term nerve pain. The goal was to see if targeting a…

This study looked at whether a program including gentle exercise (Tai Chi), nutritional support, and regular medical check-ups could help women over 70 with breast cancer stick to their hormone therapy. The program aimed to manage side effects like joint pain and vitamin D defici…

This study looked at whether placing infants with severe bronchiolitis on their stomachs (prone position) makes it easier for them to breathe. Sixteen babies under 6 months old on breathing support were tested in both face-down and face-up positions. The goal was to see if the fa…

This study tested a program called PROADAPT for older adults with cancer who were about to have surgery. The program included gentle exercise, nutrition advice, education, and medication check-ups to help prevent weakness and complications. 148 patients took part to see if this k…

This study tested whether hearing aids could improve thinking, behavior, and quality of life in people with mild to moderate Alzheimer's disease who also have hearing loss. 51 participants were split into two groups: one got active hearing aids right away, the other started with …

This study looked at whether women with severe vaginal prolapse can have surgery and go home the same day. 38 women were treated at three hospitals, and researchers tracked how many were successfully discharged on the same day, why some couldn't, and how satisfied they were. The …

This study looked at whether gabapentin and memantine can reduce the constant back-and-forth eye movements (nystagmus) in people with oculopalatal tremor, a condition caused by brainstem damage. Seven adults took each drug separately, and researchers measured eye movement speed a…

This study followed 255 women with gestational diabetes to see if a blood test during pregnancy could predict who will develop abnormal blood sugar after giving birth. Researchers measured three markers in the blood (CRP, MDA, and adiponectin) and checked glucose tolerance three …

This study looked at 20 adults in the ICU who were on breathing machines for lung failure. When it was time to see if they could breathe on their own, researchers compared two methods: one with low pressure support and one that automatically adjusts for the breathing tube. The go…

This study looked at why some people with frontal lobe epilepsy have trouble taking their medication as prescribed. Researchers used a classic economic game called the prisoners' dilemma to measure cooperative behavior, and compared 30 patients to healthy volunteers. They also us…

This study used special MRI scans to learn more about medullary sponge kidney, a rare condition that can cause kidney stones and other problems. Researchers compared 33 adults with the disease to healthy volunteers to see if MRI could detect early changes in kidney function. The …

This study looked at cells from 21 children and adults with BPAN, a rare brain disease. Researchers wanted to see if the cells have trouble handling stress, which might explain why brain cells die. No new treatments were tested, but the findings could help future research.

This study looked at how the brain handles speech sounds in people with language impairment or hearing loss. Researchers measured brain responses to syllables in 25 participants to find differences between these groups. The goal was to better understand the underlying problems, w…

This study looked at brain wave patterns in 108 women to see if overeating and obesity share similarities with addiction. Researchers compared obese women with and without eating disorders to lean women. They used a simple listening task and EEG to measure brain responses, aiming…

This study looked at 100 people over 65 living in long-term care units to see how many have low vitamin C levels and what factors increase that risk. Researchers checked blood samples and looked for risk factors like diet and health conditions. The goal was to understand why defi…

This study looked for signs of immune tolerance in 18 people who had hand or face transplants at least a year earlier. Researchers tested blood and skin samples for markers that might show who can safely take less anti-rejection medicine. The goal is to reduce the need for lifelo…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol levels. Researchers measured the density of a protective pigment in the macula (the central part of the retina) to understand why some patients still develop vision problems despite vitami…

This study looked at 82 patients with age-related macular degeneration (AMD) to measure inflammation markers in the fluid of their eyes. The goal was to find specific markers that could help explain the dry form of AMD, for which there is no treatment. By comparing these markers …

This study aimed to understand how the brain's wiring changes with age. Ten healthy adults aged 18 to 50 had special MRI scans to map connections between brain regions. The researchers developed new markers to track these changes, but the study did not test any treatment or inter…

This study looked at 3 children with dyscalculia (a math learning disability) over 3 years. Researchers wanted to see if their main difficulty is remembering math facts or automating counting procedures. Children solved simple addition problems on a computer, and their response t…

This study involved 5 people with advanced melanoma who were treated with immunotherapy drugs (nivolumab with or without ipilimumab). Researchers wanted to understand how the immune system changes during treatment and what makes some patients respond better than others. They took…

This study looked at whether the ADHD rating scale can track changes in attention problems in children with epilepsy. Researchers enrolled 173 children aged 6 to 15 with both epilepsy and ADHD. The goal was to see if the scale is sensitive enough to measure improvement over 12 to…

This study looked at how the immune system becomes weakened after severe infections, injuries, burns, or major surgeries. Researchers measured immune function in 552 adults to understand when and why patients become more vulnerable to new infections. The goal is to develop better…

This study looked at 49 people with Parkinson's disease and healthy volunteers to understand how changes in two brain chemicals—dopamine and serotonin—relate to both movement and non-movement symptoms. Using special PET scans, researchers compared people at early, middle, and lat…

This study looked at how dapagliflozin, a kidney-protecting drug, changes the gut bacteria in people with chronic kidney disease who do not have diabetes. Researchers measured gut bacteria diversity and related toxins in the blood before and after 12 weeks of treatment. The goal …

This study looked at 21 people who had a heart attack to see how inflammation in the body relates to heart damage seen on MRI scans. Researchers measured specific inflammation markers in the blood and compared them to MRI images taken a week later. The goal was to better understa…

This study looked at 46 people with severe obesity who had gastric bypass or sleeve gastrectomy. Researchers used a special CT scan to measure stomach pouch volume at 3 and 12 months after surgery. The goal was to see if a larger pouch is linked to weight regain, which could help…

This study looked at healthy adults to see how smoking and alcohol use affect gene changes in the mouth that can lead to oral cancer. Researchers checked for mutations in cancer-related genes in 100 volunteers with no cancer history. The goal was to understand how these habits in…

This study looked at whether removing the fallopian tubes (salpingectomy) during a hysterectomy affects a woman's egg supply (ovarian reserve). Researchers measured hormone levels and blood flow to the ovaries in 96 women before and after surgery. They also compared two different…

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used brain scans, EEG, and eye tracking to measure development. The goal was to understand normal growth patterns, not to test a treatment.

This study looked at two strategies for treating people with multiple blocked heart arteries. One strategy used standard X-ray images to decide treatment, while the other added a pressure test called FFR to see which blockages truly needed treatment. The goal was to see which app…

This study looked at how psoriasis affects blood flow and nerve sensitivity in the skin. Researchers tested 20 people with psoriasis by delivering mild substances to the skin and measuring blood flow changes. They also tested how sensitive the skin was to touch. The goal was to b…

This study looked at how sickle cell disease affects leg muscle function. Researchers compared 77 people with sickle cell disease to healthy volunteers by measuring muscle strength and fatigue during a short exercise. The goal was to learn if muscle problems contribute to the poo…

This study involved 32 people with advanced melanoma who were being treated with Anti-PD1 drugs (Nivolumab). The goal was to track changes in different immune cells (like dendritic cells and T cells) before and during treatment. By comparing those who responded well to those who …

This study looked at why people perform better or worse when others are around. Researchers measured brain activity and eye movements in 43 healthy adults aged 18 to 35. The goal was to understand the underlying mechanism, not to test a treatment.

This study used brain scans (fMRI) to see which parts of the brain are active when doing math. It included 79 healthy right-handed children (ages 8-14) and adults (ages 18-24). The goal was to understand normal brain function during arithmetic, not to test any treatment.

This study looked at how the COVID-19 virus spreads within hospitals, affecting both patients and healthcare workers. Over 2,100 people took part to help identify risk factors and improve safety measures. The goal was to better understand transmission and protect those most at ri…

This study looked at how sleep affects the brain's ability to remember and improve motor skills that were learned just by imagining them. Fifty-one healthy right-handed adults practiced finger movement tasks in their minds, then had their brain activity measured with MEG scans be…

This study looked at why some people with C. difficile infection get sick again after treatment. Researchers measured the immune response in 56 hospitalized adults to see if it was linked to repeat infections. The goal was to better understand the role of the immune system in pre…

This study looked at 29 adults with a serious heart infection called infectious endocarditis, which can cause silent strokes. Researchers wanted to see if adding a brain MRI and a check by a nerve doctor would change how the patient was treated. The goal was to learn if these ext…

This study looked at how different types of feedback (like social or monetary) affect decision-making in healthy adults. Researchers used brain scans and a mild stimulation technique to understand which brain areas are involved. The goal is to apply this knowledge to help people …

This study looked at 136 severely injured patients in the intensive care unit who needed emergency catheters placed in their thigh. Researchers compared using ultrasound guidance versus the standard method of feeling for landmarks. The goal was to see if ultrasound reduces compli…

This study looked at how mindfulness meditation and hypnosis affect the brain and our sense of self. One hundred healthy adults underwent brain scans while doing tasks and reporting their experiences. The goal was to understand the brain areas involved in self-awareness during th…

This study looked at whether being in labour affects how fast the stomach empties a light meal. Researchers used ultrasound to measure digestion in 43 women: some in labour with or without epidural, some pregnant, and some not pregnant. The goal is to help guide safe eating recom…

This study tested a new radioactive tracer called [18F]-F13640 in 20 healthy adults to see how well it can image certain brain receptors (5-HT1A) using PET scans. The goal was to understand how the tracer behaves in the body and whether it gives reliable results. No treatment was…

This pilot study involved 6 healthy women who ate biscuits made with a special type of wheat bran that can be traced in the body. Researchers collected breath, urine, blood, and stool samples over 24 hours to measure how the bran is fermented in the gut. The goal was to identify …

This study looks at how a medicine called dexamethasone, given during pregnancy to prevent a condition called congenital adrenal hyperplasia (CAH), affects children's thinking and memory. Researchers compared children who were exposed to the drug before birth with those who were …

This study looks at how gut bacteria in people with chronic kidney disease (CKD) produce harmful toxins that can lead to heart problems. Researchers collected stool samples from 20 CKD patients and placed them into an artificial intestine to test if certain probiotics can reduce …

This study looked at different ways to estimate the height of children in the pediatric intensive care unit (ICU), where standard measuring is often impossible due to medical equipment or sedation. Researchers compared several estimation methods to the World Health Organization's…

This study looked at how children aged 8 to 17 with two cochlear implants perceive sound in three-dimensional space. Using virtual reality and motion tracking, researchers measured how well the children could point to where sounds came from. The goal was to understand their spati…

This study used PET scans to look at a specific type of brain receptor in 16 healthy men aged 20-35. The goal was to measure how these receptors work and how a drug called clonidine blocks them. It was a research-only study with no direct treatment benefit.

This study collected blood samples from nearly 1,900 people in families where at least two members have a blood disorder called dysglobulinemia, which includes multiple myeloma and related conditions. The goal was to find genetic differences that might increase the risk of develo…

This study looked at how cochlear implants work in noisy environments. Researchers tested 28 adults (some with normal hearing, some with cochlear implants) to measure how different sound channels interfere with each other. The goal was to find better ways to adjust the implant se…

This study looked at 11 people with end-stage kidney disease to understand where phosphate comes from during dialysis. Using a special MRI technique, researchers measured phosphate and energy molecules inside cells during a 4-hour dialysis session. The goal was to learn more abou…

This study used MRI scans to see how fingertips change shape when pressed or rubbed. Eight healthy adults had their index fingers scanned while light forces were applied. The goal was to collect data to create realistic computer models of the finger, which could help improve how …

This study looked at over 1,000 people with drug-resistant partial epilepsy to find out what might predict sudden unexpected death (SUDEP). Researchers measured drops in oxygen levels during seizures and tracked other risk factors. The goal is to better understand and eventually …

This study looked at how the brain's electrical activity changes when healthy people get mentally or physically tired. Researchers used non-invasive brain scans (EEG and MEG) to find patterns linked to fatigue. The goal was to better understand these signals, not to treat any dis…

This study tested whether specific molecules in the blood (microRNAs) can identify epilepsy patients who have dangerous drops in oxygen during seizures. Researchers monitored 75 adults with drug-resistant epilepsy in a hospital unit, comparing those who had breathing problems wit…

This study followed 633 people who had a stroke or mini-stroke to understand why they stop taking medicines that prevent another stroke. Researchers checked pharmacy records and called patients one year later. They looked at factors like age, mood, support, and number of pills. T…

This study surveyed 55 men who have sex with men who use psychoactive substances like synthetic cathinones during sex. Researchers used questionnaires to understand whether hypersexual behavior is an addiction itself or triggered by the drugs. The goal is to better understand the…

This study looked at 154 older adults (70+) having hip fracture surgery to compare a special low-dose spinal anesthesia with general anesthesia. The goal was to see which method keeps blood pressure more stable during surgery and reduces heart complications. Results will help doc…

This study looked at 267 women with early-stage cervical cancer to see if removing only the sentinel lymph node (the first node cancer might spread to) is as safe as removing all pelvic lymph nodes. Both groups had a radical hysterectomy. The goal was to compare complications, co…

This study looked at 98 critically ill adults who had trouble being taken off a breathing machine. It compared two methods of a 'breathing trial' to see which helped them stay off the ventilator sooner. The goal was to find the best approach to reduce time on the machine and avoi…

This study looked at how well vaccines protect adults who have had a stem cell transplant. After transplant, the immune system is weak, so re-vaccination is important. Researchers measured antibody levels in 152 participants after they received standard vaccines. The goal was to …

This study looked at 460 adults who came to the emergency room after a traumatic event, like a serious injury or threat of death. Researchers wanted to find out which factors—biological, psychological, and social—could predict who would develop post-traumatic stress disorder (PTS…

This study aimed to find out how many emergency room visits during flu season are actually caused by influenza, even if not recorded that way. Researchers tested over 2,400 adults visiting the ER for medical reasons. The goal was to better understand the true burden of flu on hos…

This study gathered stool samples from 14 people with bone or joint infections who were receiving long-term antibiotics injected under the skin. The goal was to create a collection of gut bacteria samples for future research on antibiotic resistance. No treatments or results were…

This study looked at 25 people who carry one copy of a mutated AGXT gene, which is linked to a rare condition that causes high oxalate levels and kidney stones. Researchers compared those who had kidney stones with those who didn't, to see if diet, lifestyle, or other factors exp…

This study looked at how the brain's cerebellum and fronto-parietal networks work together to connect eye movements with visual perception and attention. Researchers tested 24 people, including healthy adults and those with cerebellar disease, using behavioral tasks. The goal was…

This study looked at whether certain heart measurements can help doctors decide when to give fluids to patients with severe lung injury (ARDS) who are lying on their stomachs. Researchers monitored 33 adults to see if changes in heart output during specific maneuvers could predic…

This study examined tissue samples from 50 patients with staph bone or joint infections to see if bacteria hide inside cells. Researchers used special staining to find intracellular staphylococci and identify which cell types they live in. The goal was to better understand why th…

This study followed 88 adults who had a moderate to severe traumatic brain injury (TBI) to see if hormone deficiencies affect their quality of life over 18 months. Researchers measured quality of life, attention, memory, and thinking skills. The goal was to better understand how …

This study looked at whether drinking calvados (a strong apple brandy) during a high-calorie festive meal helps with digestion, as some people believe. Eight healthy volunteers ate a large meal and either had water or calvados with sorbet in the middle. Researchers used ultrasoun…

This study looked at 182 people who already had advanced AMD in one eye and early-stage AMD in the other. Researchers used a detailed vision test called microperimetry to see if it could predict when the better eye would progress to the advanced stage. The goal is to catch high-r…

This study looked at how a 40-minute afternoon nap affects communication between key brain regions. Researchers used brain scans to compare connectivity before and after the nap in 55 healthy adults. They also checked if people who often remember dreams showed different changes t…

This study looked at why people with sickle cell disease get leg ulcers more often than others. Researchers measured blood flow and nerve function in 70 adults with and without ulcers. They also tested blood and wound fluid to find clues about what causes these slow-healing sores…

This study looked at how a common bacteria, Staphylococcus aureus, affects skin inflammation in people with atopic dermatitis (eczema). Researchers applied patches containing the bacteria to the skin of 7 participants (both with and without eczema) to see if it caused a flare. Th…

This study followed 65 people with cystinosis for two years to see how closely they took their cysteamine medication and whether that affected their brain health. Researchers used special devices to track medication use, performed memory and vision tests, and used brain scans to …

This study looked at whether a brief pause during angioplasty (called postconditioning) can reduce heart muscle damage in patients having a heart attack. It included 72 adults whose heart artery was partially open when they arrived at the hospital. The goal was to see if the prot…

This study looked at 24 children (ages 6-17) with narcolepsy or hypersomnia to see if changes in their daily metabolism explain why they often gain weight and become obese. Researchers measured energy use at home and in the hospital using activity trackers. The goal was to uncove…

This study tested whether trained peer counselors—mothers who previously breastfed a preterm baby—could help new mothers of preterm infants breastfeed longer. About 1,774 families in European NICUs took part. The program included weekly face-to-face support during hospital stay a…

This study looked at why hospitalized children ages 2 to 8 eat less, focusing on food pickiness and neophobia (fear of new foods). Researchers measured how much food children ate 48 hours after admission and asked parents about their child's usual eating habits. The goal was to u…

This study tested whether a transitional care program led by an advanced practice nurse could reduce 30-day hospital readmissions for elderly patients (75+) discharged from a geriatric ward. 630 participants were enrolled. The program focused on bridging the gap from hospital to …

This study looked at how two parts of the brain, Broca's area and the mid-cingulate cortex, work together to control speech. Twenty-three healthy, right-handed adults had brain scans while doing tasks. The goal was to learn more about the basic brain functions that might help imp…

This study examined 1072 vaccinated adults who later caught COVID-19. Researchers analyzed the virus's genetic code and measured antibody levels to see if certain variants were more common in these cases. The goal was to understand why some vaccinated people still get infected, n…

This study looked at 11 adults with acute respiratory distress syndrome (ARDS) to see if their body position (lying flat at 0° or slightly raised at 30°) changes the esophageal pressure reading used to set ventilators. Researchers measured pressure at both angles to find out if p…

This study tracked 289 healthcare workers in short-stay hospital wards to see how often they caught the flu, both with and without symptoms. Researchers wanted to understand the hidden spread of flu among staff, which can put vulnerable patients at risk. The findings may help enc…

This study collected MRI and 3D ultrasound images from 2 men who had their prostate removed due to cancer. The goal was to create a database that researchers can use to develop a computer system that spots tumors without needing a biopsy. This early step focuses on gathering data…

This study tested whether a special PET/MR scan can detect which carotid artery plaques are more likely to cause a stroke. Researchers compared 12 people with recent stroke symptoms and 6 without symptoms, all having significant plaque buildup. The goal was to see if the scan cou…

This study aims to find normal oxygen pressure values in the upper arm and determine what level indicates a serious lack of blood flow (chronic limb ischemia). Researchers measured oxygen levels in 39 healthy volunteers and reviewed past patient records. The goal is to create cle…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage cirrhosis patients who also develop sudden kidney injury. The goal was to see if heart function measurements could predict which patients would not tolerate fluid replacement therapy…

This study looked at fat tissue in people with advanced chronic kidney disease (stage V) who do not have diabetes. Researchers compared fat cells from 15 kidney disease patients and 15 healthy volunteers to understand why metabolic problems like weight loss and insulin resistance…

This study looked at 25 adults in the intensive care unit with moderate to severe acute respiratory distress syndrome (ARDS). Researchers tested a new, simple way to measure if the small airways in the lungs close during normal breathing. The goal was to better understand how the…

This study tested a new scale called the SOFMER Activity Scale (SAS) to measure how much physical and cognitive activity patients can do in follow-up care and rehabilitation departments. Researchers enrolled 152 patients aged 2 and older to see if the scale is accurate, reliable,…

This study tested a new automated method to grow cancer cells from patients inside chicken eggs. Researchers used samples from 101 people with metastatic cancers like prostate, breast, and lung cancer. The goal was to see if the automated system could successfully grow tumors at …

This study looked at 50 people who had a pancreas-kidney transplant to understand why some still have blood sugar problems. Researchers measured bile acids and gut hormones before and after transplant. The goal was to learn how the surgery changes these substances, not to test a …

This study looked at whether using a special bag during laparoscopic surgery (for removing fibroids or the uterus) can prevent stray cells from spreading inside the belly. 48 women were randomly assigned to have the procedure with or without the bag. The main goal was to check fo…

This study looked at how symptoms of Hereditary Hemorrhagic Telangiectasia (HHT) impact quality of life. Researchers used a special questionnaire created by patients to measure different aspects of well-being. 185 adults with HHT took part to help doctors better understand which …

This study aims to determine normal reference values for a blood clotting test called dRVVT in healthy pregnant women. Pregnancy naturally increases the risk of blood clots, and abnormal test results can signal antiphospholipid syndrome, a condition that raises the chance of seri…

This study looked at 84 adults who had open-heart surgery through a chest incision (sternotomy). Researchers used a pain-mapping tool called algocartography two days after surgery to measure the area of increased sensitivity around the scar. They then checked if that area could p…

This study checked if a child's inability to bend one knee as far as the other could be a sign of a dislocated meniscus. Researchers looked at 98 children with a symptomatic discoid lateral meniscus, a condition where the knee cartilage is abnormally shaped. They found that this …

This study looked at 20 adults who had NMDA receptor encephalitis, a rare brain disease, to understand its long-term effects on their social and emotional well-being. Researchers used questionnaires to measure memory, mood, sleep, and quality of life after the acute phase. The go…

This study tested whether a coordinated care pathway, supported by an electronic information system shared among patients and healthcare providers, could improve compliance with recommended pregnancy monitoring. Over 1,500 pregnant women in France participated. The main goal was …

This study looked at whether using a bedside lung ultrasound in the emergency department for patients with shortness of breath can lower the risk of death or return to the hospital within 3 months. About 385 adults with breathing trouble were included. The goal was to see if this…

This study looked at how the brain controls and adjusts quick eye movements called saccades, which help us see and interact with the world. Thirty-six healthy adults performed eye-tracking tasks inside an MRI scanner so researchers could see which brain areas were active. The goa…

This study looked at whether ultrasound can help doctors see what's in a child's stomach before emergency surgery. Knowing this helps them choose the safest way to give anesthesia and reduce the risk of stomach contents entering the lungs. The study included 146 children and aime…

This study looked at 1,000 adults aged 40-80 with type 2 diabetes or obesity to find the best way to screen for advanced liver scarring (fibrosis) caused by fatty liver disease. Researchers compared different non-invasive blood tests and elastography (a special ultrasound) to see…

This study tested whether placing special electrodes on the brain can detect spreading waves of electrical activity that may signal new damage. Twenty patients with severe head trauma or brain bleeding were monitored in intensive care. The goal was to see if this technique is saf…

This study looked at whether a technique called postconditioning, done during emergency heart artery opening, can reduce damage to the heart muscle and improve blood flow in 44 heart attack patients. Researchers used MRI scans to measure the area of blocked small blood vessels an…

This study looked at whether a protein called periostin is higher in the blood of people with fibrous dysplasia, a rare bone disease that can cause pain and fractures. Researchers measured periostin levels in 65 patients to see if it could help tell how severe the disease is. The…

This study looked at whether electrical measurements from the inner ear can help doctors set cochlear implants more accurately. Researchers tested 49 adult implant users, measuring nerve responses and comparing them to standard fitting levels. The goal was to create models that p…

This study looked at 82 adults getting a liver transplant to see if using a special blood test called ROTEM helps doctors manage bleeding better than standard tests. The goal was to see if ROTEM could reduce the amount of blood products given during surgery. Researchers tracked c…

This study looked at how cochlear implant microphones change as they get older or dirty, and whether different signal coding strategies are affected differently. Researchers tested 81 French-speaking adults with normal hearing to measure how well they recognized syllables. The go…

This study tested a special MRI technique called T1rho to measure hip cartilage in 31 healthy volunteers. The goal was to see if the method gives consistent results and to establish normal values. This could help doctors detect early signs of hip osteoarthritis before symptoms ap…

This study looked at how changes in mouth touch, temperature, and texture perception affect food preferences in people with head and neck cancer. Researchers compared 72 patients to healthy volunteers using a simple pressure test and rating scales. The goal was to understand why …

This study followed 230 cystic fibrosis patients to understand why some develop diabetes that can later reverse. Researchers looked at genetics, lung health, and infections to find clues. The goal is to improve how we screen and treat diabetes in people with cystic fibrosis.

This study looked at 100 adults who had a transient ischemic attack (TIA) and were treated in emergency rooms in Lyon, France. Researchers wanted to see how much patients understood about TIA, including its symptoms, risk factors, and what to do if it happens again. The goal is t…

This study tested whether a special hospital team and electronic alerts could help doctors and nurses better follow guidelines for caring for malnourished children. Over 1,400 children and hospital staff took part. The goal was to see if better adherence to guidelines would reduc…

This study looked at 32 adults with severe lung failure (ARDS) who were on breathing machines. Researchers measured pressure inside the lungs when patients were lying on their back and then on their stomach (prone position). The goal was to see if stomach-lying changes lung press…

This study looked at whether continuous kidney replacement therapy can cause temporary heart muscle weakness (myocardial stunning) in critically ill patients with severe acute kidney injury. Researchers monitored 42 adults using echocardiograms to detect changes in heart wall mot…

This study looked at 139 adults with high blood pressure to find out why some people respond better to certain blood pressure drugs than others. Researchers examined factors like genetics, diet, body size, and heart activity. The goal was to gather knowledge that could help perso…

This study tested a new virtual reality training program designed to help people with hearing loss better locate where sounds are coming from. Researchers used a special VR system to train 79 participants, including those with hearing loss and those with normal hearing. The goal …

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation to see if these changes relate to pain rel…

This study collected blood samples from 28 adults with thyroid disorders to help standardize TSH (thyroid-stimulating hormone) tests used by different labs and manufacturers. The goal is to make test results comparable no matter where they are done, improving diagnosis and monito…

This study looked at 40 adults having heart surgery with a heart-lung machine. The goal was to measure how fast pulse waves travel from the heart to different parts of the body. This helps doctors understand why blood pressure readings can differ between the arm and the leg durin…

This study looked at a new method to set breathing machines for children during anesthesia. Instead of using a standard breath size, they measured the air that actually reaches the lungs (alveolar ventilation) using a special device. The goal was to find a steady target that keep…

This study looked at the genetics of a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE) syndrome, which causes both scarring and air sac damage. Researchers compared 250 participants, including patients with CPFE, those with only scarring or only emphys…

This study looked at whether people with cystic fibrosis (CF) have different immune responses to COVID-19. Researchers tested blood samples from 331 children and adults with CF in Europe over two years to see how many had COVID-19 antibodies. They also tracked symptoms, lung func…

This study looked at how common muscle loss (sarcopenia) is in people with a type of inflammatory arthritis called spondylarthropathy. Researchers measured muscle strength, walking speed, and body composition in 106 adults. The goal was to better understand the problem so doctors…

This study tested whether telephone interviews or video calls after a stroke hospital discharge can improve how well patients understand and take their medications. 54 adults who had an ischemic stroke and were returning home took part. Researchers measured patients' knowledge, a…

This study looked at genes in children with alpha-1 antitrypsin deficiency, a condition that can cause liver disease. Researchers compared the DNA of children who had liver problems with those who did not, to find genetic markers that might predict severe liver damage. About 296 …

This study tested whether a simple, non-invasive eye scan could predict how well blood flows through the heart's tiny arteries. Researchers measured blood flow in the heart and eyes of 101 people with coronary artery disease. They used machine learning to see if eye measurements …

This study looked at 14 adults with chronic hepatitis B to find human proteins that stick to the virus. Researchers purified virus particles from blood samples and used mass spectrometry to identify these proteins. The goal was to learn how the virus uses host proteins to replica…

This study looked at whether a protein called IRAP, found in the blood, can be used as a marker for insulin sensitivity (how well the body uses insulin). Researchers tested 21 healthy adults using a precise method called a hyperinsulinemic-euglycemic clamp. The goal was to see if…

This study reviewed 50 adults who had jaw surgery to fix an anterior open bite (a gap between front teeth). Researchers wanted to see if tongue re-education (training to stop pushing the tongue between teeth) helped prevent the gap from coming back. The goal is to improve how doc…

This study followed 281 people who had a severe type of heart attack called STEMI. Researchers collected blood samples, imaging scans, and health data to find new markers that could predict recovery and long-term outcomes. The goal was to better understand how the heart heals and…

This study looked at cells from the umbilical cords and cord blood of newborns who have a parent with hereditary hemorrhagic telangiectasia (HHT), a rare disorder that causes abnormal blood vessels and bleeding. Researchers grew these cells in the lab to compare their genes and b…

This study looked at 10 adults with chronic hepatitis C to find human proteins stuck to the virus. By identifying these proteins, researchers hope to learn how the virus spreads and find new ways to stop it. The study did not test any treatment, only observed the virus in blood s…

This study looked at 24 adults with fibrous dysplasia, a rare bone disease that causes pain, fractures, and deformities. Researchers wanted to find out if small molecules called microRNAs in the blood and bone tissue are linked to how severe the disease is. The goal was to better…

This study looked at how 143 patients (124 transgender and 19 cisgender men) felt about their phalloplasty surgery, focusing on sexual quality of life, function, and satisfaction. Researchers surveyed patients at least one year after surgery to see how their lives changed. The go…

This study looked at how platelets (a type of blood cell) change over time in people who had a brain aneurysm rupture. The goal was to better understand why some patients develop delayed brain injury days later. Researchers measured platelet activation in 90 patients and compared…

This study looked at 271 children and adults with lupus to find genetic and immune system differences. The goal was to identify gene mutations linked to the disease, especially in children. Researchers hope this will lead to a better understanding of what causes lupus and how it …

This study looked at 5 people with a torn aorta (aortic dissection) who needed a stent to fix it. Researchers used special MRI scans before and after surgery to measure blood flow changes in the aorta. The goal was to see if MRI can help doctors evaluate how well the treatment wo…

This study followed 165 adults newly diagnosed with lung or head & neck cancer to understand how their smoking and drinking habits influence treatment results. Researchers used questionnaires to gather information on social factors, addiction levels, and barriers to quitting. The…

This study looked at tiny particles that wear off hip implants in 55 adults. Researchers wanted to understand which types of particles cause the most inflammation in the surrounding tissue. The goal is to improve knowledge about why some hip replacements fail sooner than expected…

This study looked at cancer survivors to find out how many have unhealthy habits like smoking, poor diet, or lack of exercise. The goal was to learn about these behaviors so doctors can offer better prevention advice. 46 survivors who had finished heavy treatment within the past …

This study looked at 60 children having planned surgery under anesthesia. Doctors wanted to see if giving a small amount of fluid (3 ml per kg of body weight over 2 minutes) could predict whether the child would need more fluids later. The goal is to avoid giving too much fluid, …

This study looked at whether eating einkorn, an ancient cereal, could change the types of bacteria in the mouth. Researchers measured harmful bacteria linked to cancer risk in 31 healthy adults before and after adding einkorn to their diet. The goal was to see if a simple dietary…

This study looked at how the brain combines information from faces and voices to decide a person's gender. 38 healthy adults underwent brain scans while performing a gender classification task. The goal was to understand which brain areas are involved and how visual and auditory …

This study looked at whether a bedside ultrasound can accurately measure thigh muscle in critically ill children, compared to the gold-standard MRI. Researchers studied 35 children in intensive care who already needed an MRI. The goal was to see if ultrasound could be a reliable,…

This study looked at 20 people with a long-term balance disorder that causes blurry vision when moving their head. Researchers wanted to see if fast, automatic eye movements called covert saccades help improve vision and quality of life. Participants underwent tests to measure th…

This study looked at 116 people with advanced neuroendocrine tumors to see if a gene marker called MGMT could predict which chemotherapy works best. Researchers compared two chemo drugs—alkylating agents and oxaliplatin—based on whether the tumor had a methylated (active) or unme…

This study looked at how meditation affects attention and emotion regulation in 169 healthy adults aged 25 to 70. Researchers used brain scans (MRI, EEG, MEG) and computer tasks to measure brain activity and stress markers. The goal was to understand the mechanisms behind meditat…

This study used brain scans to compare a specific serotonin receptor (5-HT4) in 40 people with mild-to-moderate Parkinson's disease versus healthy volunteers of similar age. The goal was to see how these receptors relate to movement, thinking, and mood symptoms. No treatment or d…

This study looked at how the brain processes sound in adults who are deaf and have two cochlear implants, compared to people with normal hearing. Researchers used brain scans to see if the timing between activating the two implants affects how well the brain handles sound from bo…

This study aimed to create a simple questionnaire that can predict whether someone has low vitamin D levels, without needing a blood test. Researchers collected data from over 2,500 adults aged 18 to 70. The goal is to help doctors identify who really needs a vitamin D test, savi…

This study looked at 76 women with congenital toxoplasmosis to see if pregnancy raises the risk of eye inflammation (retinochoroiditis). Researchers tracked eye exams during and after pregnancy and compared them to non-pregnancy periods. The goal is to better inform women about t…

This study looked at how children's brains process logical reasoning and how that connects to their math skills. Researchers used brain scans (fMRI) on 137 healthy children aged 8 to 14 while they solved reasoning problems. They then compared brain activity to math test scores ta…

This study looked at whether circulating tumor cells (CTCs) found in the blood can help predict if oropharyngeal cancer will come back after treatment. Researchers took blood samples from 12 patients at different times—before, during, and after treatment—to count and study these …

This study tested a new type of eye-movement training for people who lost part of their vision after a stroke or head injury. The training was designed to work automatically, without requiring patients to consciously focus on their blind area. Researchers measured improvements in…

This study looked at how the human brain supports using and improving tools. Researchers used brain scans (fMRI) on 70 healthy, right-handed adults aged 18-65 to see which brain areas are active during tool tasks. The goal was to understand what makes human tool use unique compar…

This study looked at how well the ReVive™ SE device works to restore blood flow in the brain during a stroke. It involved one patient with a blocked artery. The goal was to see if the device is useful in standard stroke care.

This study tracked 69 adults with digestive cancers to see how their sense of taste and smell changed after their first round of chemotherapy. Researchers found that many patients reported liking fewer foods, which can lead to poor nutrition. The goal was to better understand the…

This study looked at how healthcare practitioners move their hands and fingers when inserting a peripheral IV catheter. Researchers measured the forces applied to the skin and veins, as well as needle angles and finger pressure. The goal is to use this data to create more realist…

This study looked at whether certain compounds in cooked food, called AGEs, cause changes in kidney blood flow and oxygen use. Ten healthy young men ate either a high-AGE meal (chicken nuggets) or a low-AGE meal (eggs), and their kidneys were scanned with special imaging. The goa…

This study collected and stored blood and tissue samples from over 2,100 people with digestive cancer that spread to the lining of the abdomen. The goal was to create a high-quality biobank for future research on why some patients' cancers resist treatment. No new treatments were…

This study measured vitamin C levels in 434 hospitalized patients over age 75 to find out how many have low vitamin C (hypovitaminosis C). Researchers also looked at risk factors like diet and health conditions. The goal was to better understand who is at risk so doctors can diag…

This study looked at 38 adults having heart surgery to better understand how the heart muscle gets injured during the procedure. Researchers used cardiac MRI scans and blood tests (troponin levels) to measure damage and swelling. The goal was to find links between the two methods…

This study looked at how hard babies with a congenital diaphragmatic hernia (a hole in the muscle that helps them breathe) have to work to breathe after surgery. Researchers compared a standard breathing machine to a newer one called NAVA, which senses the baby's own breathing si…

This study looked at how the brain manages the process of checking our own actions, a skill that is often disrupted in people with obsessive-compulsive disorder (OCD). Researchers used brain scans (fMRI and EEG) on 51 healthy adults while they performed tasks that required checki…

This study collected brain PET scans from 41 healthy adults aged 20-65 to create a reference database. Doctors can compare these normal scans to those of epilepsy patients to more precisely locate where seizures start, helping guide surgery when medications fail. The goal is to i…

This study tested a new virtual reality training program to help adults with two cochlear implants locate where sounds are coming from. 12 participants completed up to 8 rehab sessions using visual or combined audio-visual feedback. The goal was to see if this approach could impr…

This study tested whether imagining a finger movement (motor imagery) combined with a gentle electrical current to the brain (tDCS) could improve learning of a complex finger sequence. 64 healthy young and elderly adults participated. The goal was to see if this combination boost…

This pilot study looked at whether giving intravenous immunoglobulins (IVIG) to children with toxic shock syndrome is practical and promising. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The study enrolled 30 children in intensive care to see if a lar…

This study looked at 85 women with cystic fibrosis to find out how many carry the HPV virus, which can lead to cervical cancer. Researchers checked for HPV and abnormal cervical cells using a Pap test and DNA testing. The goal is to help doctors better understand the need for reg…

This study looked at 12 people with chronic bilateral vestibular hypofunction (a balance disorder causing blurry vision during head movement) and 12 healthy volunteers. Researchers measured how quickly and often the eyes make tiny, automatic saccades during head turns to see if t…

This study looked at how a non-invasive brain stimulation technique called tDCS changes brain activity and chemistry in 37 healthy adults. Researchers used advanced brain scans to see the effects during and after a single 30-minute session. The goal is to better understand how tD…

This study followed 1,100 adults with severe obesity who were taking the weight-loss drug WEGOVY. Researchers tracked weight changes over 12 months and looked for patterns in who responded best. They also used artificial intelligence to find which factors—like eating habits or bl…

This study looked at how people with brain injuries or migraines process sounds, including attention, memory, and emotions. Researchers used hearing tests and brain scans (EEG, MEG, MRI) to understand these effects. The goal was to better characterize auditory problems, not to te…

This study involved 49 healthy volunteers to test a new MRI technique that can trace nerve pathways in the spinal cord. The goal was to see if it's possible to create a detailed map, or atlas, of these pathways. This atlas could help doctors better understand and treat spinal cor…

This study tested whether a special type of brain scan (PET/MRI) is practical for children aged 5 to 17 with brain tumors. The scan combines two imaging methods to give doctors more detailed information about the tumor before surgery. Fifteen children participated to see if the s…

This study looked at how the heart's muscle stiffness (fibrosis) changes as people age normally. Researchers used MRI scans and blood tests to measure fibrosis in 74 healthy adults. The goal was to better understand age-related changes in heart function, not to treat any disease.

This study looked at 47 people with Hereditary Hemorrhagic Telangiectasia (HHT) who also have liver involvement. The goal was to see if measuring blood pressure in the lungs during exercise could catch early signs of heart failure that standard resting tests miss. Researchers com…

This study looked at 39 people with multiple sclerosis who have ongoing vision issues. Researchers wanted to understand if the vision loss is caused by damage to the nerve coating (demyelination) or by the nerve cells dying off (degeneration). Participants had eye exams, scans, a…

This study looked at how people with congenital amusia (tone deafness) process sound and memory compared to those without it. Researchers used brain scans like EEG, MEG, and MRI to measure brain activity during listening and memory tasks. The goal was to better understand the bra…

This study looked at whether children with severe infectious shock develop immune suppression, similar to what is seen in adults. Researchers measured immune markers in 105 children admitted to intensive care and compared them to healthy children having surgery. The goal was to u…

This study looked at how three different forms of DHA (an omega-3 fat) are processed in the body. Four healthy men aged 60-70 took labeled DHA, and researchers measured its levels in blood cells and plasma after 6 hours. The goal was to find which form might best reach the brain.

This study looked at how brain scans (fMRI and MEG) relate to electrical signals recorded directly from the brain (intracranial EEG) in people with epilepsy and healthy volunteers. The goal was to better identify the area causing seizures and map healthy brain networks to avoid d…

This study looked at whether listening to familiar or favorite music can improve brain responses in people with consciousness disorders after a coma, as well as in healthy volunteers. Researchers measured brain waves to see if music helps the brain process personal information li…

This study looked at 189 adults who had COVID-19 to see how long their antibodies last. Researchers collected blood, saliva, and nose swabs at 6 and 12 months after infection. The goal was to understand the immune response and whether protective antibodies persist over time.

This study looked for a substance in the blood (called HLA-G5) that might help doctors predict which flu patients in the intensive care unit (ICU) are at higher risk of severe breathing problems or death. Researchers studied 227 adults and children with severe flu. They also coll…

This study looked at how different parts of the brain talk to each other. Researchers used brain scans and mild electrical stimulation to test a theory about brain waves. 157 healthy adults took part. The goal was to understand normal brain communication, not to treat any disease…

This study looked at how healthy people remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI to understand which parts of the brain are involved in recalling memories. The goal was to learn more about memory and attention, n…

This study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease more dangerous. Researchers tracked survival, hospital stays, and genetic factors. The goal was to better understand why some cases are so severe, not to test a new treatm…

This study looked at 59 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers tracked changes in certain immune cells (T cells) in the blood and gut over one year to see if they could predict when the disease would come back. The goal…

This study looked at whether people with type 2 diabetes who show signs of premature aging are more likely to develop heart muscle disease. Researchers measured aging markers in blood and used heart imaging in 150 adults aged 40-55 with diabetes but no heart symptoms. The goal wa…

This study tested whether taking 4.5 grams of chitin-glucan fiber daily for three weeks could improve gut bacteria and related health markers in 19 adults with abdominal obesity and cardiometabolic risk. Researchers measured changes in gut bacteria, fatty acids, and digestion. Th…

This study looked at a specific immune marker (mHLA-DR) in 81 elderly patients over 75 with multiple chronic conditions. The goal was to understand how aging and having several illnesses together affect the immune system. Researchers measured mHLA-DR levels in the blood to gather…

This study looked at 10 males who had surgery for hypospadias (a birth defect where the urine opening is not at the tip of the penis) during childhood. The goal was to see how they were doing after puberty, checking for complications, urinary symptoms, and sexual function. Resear…

This study looked at 66 adults to find small molecules called microRNAs in the blood that might explain why some people with osteogenesis imperfecta (brittle bone disease) have a mild form while others have a severe form. Researchers compared people with type 1 (mild) and type 3 …