Blood protein may reveal hidden insulin problems
NCT ID NCT01648478
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a protein called IRAP, found in the blood, can be used as a marker for insulin sensitivity (how well the body uses insulin). Researchers measured IRAP levels in 21 healthy adults during a special test called a hyperinsulinemic-euglycemic clamp, which is the gold standard for measuring insulin sensitivity. The goal was to see if IRAP levels match the results of the clamp test, which could lead to a simpler blood test for insulin resistance in the future.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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21 people
The number who actually took part.
- Start date
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Jun 2012
- Finished
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Sep 2012
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and women (sex ratio = 1) * Aged from 18 to 35 years * Fasting glycemia \< 6mmol/L * Total cholesterol \< 7mmol/L * Triglycerides \< 1.5 mmol/L * CRPus \< 5 mg/L * Creatinine clearance \< 80mL/min according to Cockroft formula * Liver enzymes (ALanine AminoTransférase and ASpartate AminoTransférase) \< 1.5 times normal values Exclusion Criteria: * Subject not in compliance with the recommendations of French National Law in force * Medical history of metabolic disease (diabetes, dyslipidemia), endocrine disease, renal insufficiency * Drug use that could affect glucose metabolism and the renin angiotensin aldosterone system * Blood pressure \> 140/90mmHg * Tea and coffee consumption more than 5 cups per day * Subject who smoke more than 5 cigarettes per day
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, France
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Other studies related to the condition(s) this trial covers.
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