Hospices Civils De Lyon

This study tests whether taking clomiphene citrate (a hormone pill) for 9 months before a second surgical sperm retrieval helps men who have no sperm in their semen (non-obstructive azoospermia) and had a failed first retrieval. About 128 men will be randomly assigned to receive …

This study tests whether a drug called dexmedetomidine, which calms the body's stress response, can help people with severe septic shock who are not responding to standard treatments. About 360 adults will receive either dexmedetomidine plus usual care or usual care alone. The ma…

This study tests whether giving the seizure medicine levetiracetam to adults who have had a spontaneous brain bleed can improve their recovery and reduce disability. About 580 participants will receive either the drug or a placebo for a short time after the bleed. The goal is to …

This study tests whether a non-invasive, inexpensive arm cuff treatment (remote ischemic postconditioning) can reduce deaths in adults with septic shock in the ICU. About 720 participants will receive the cuff procedure or standard care. The main goal is to see if more people are…

This study tests a new treatment for a rare and fast-growing cancer of the digestive system (neuroendocrine carcinoma). It combines standard chemotherapy (FOLFIRI) with two immunotherapy drugs (zimberelimab and domvanalimab) to see if it helps people live longer. About 122 adults…

This study looks at whether a special dental follow-up program (with text message reminders and tips) can help people with type 2 diabetes and gum disease better control their blood sugar. About 516 adults who have already had gum treatment will be split into two groups: one gets…

This study tests a new type of PET scan (68Ga-FAPI) to see if it can find breast cancer that has spread to other parts of the body better than the standard scan. It includes 45 adults with lobular breast cancer whose standard scan was negative or unclear. If successful, this new …

This study tests a new, more comfortable brain scanner (OPM MEG) that uses tiny sensors placed directly on the scalp to find where seizures start in people with epilepsy. About 70 children and adults will get this scan before their planned epilepsy surgery. Researchers will check…

This study aims to see if a breath test can quickly and painlessly diagnose respiratory infections like COVID-19 and flu. Researchers will analyze the chemicals in the exhaled breath of 1,665 adults with symptoms and compare them to healthy volunteers. If successful, this could o…

This study explores whether analyzing the chemicals in a person's breath can quickly and painlessly diagnose serious respiratory infections like COVID-19, flu, and Legionella in hospitalized adults. Researchers will collect breath samples from 777 participants using a simple beds…

This study looks at whether giving nirsevimab, a shot that protects against RSV, to babies under 6 months old can reduce wheezing that leads to hospital visits when they are 1-2 years old. Researchers will compare 218,000 children in France who got the shot with those who did not…

This study looks at whether a therapeutic education program can help patients with neuroendocrine tumors handle side effects from oral cancer drugs like everolimus and sunitinib. About 100 adults will take part, and researchers will track side effects, hospital visits, and qualit…

This study looks at whether interventional radiology—a minimally invasive procedure—can help manage pain in people with advanced or metastatic cancer. Researchers will measure pain levels and quality of life before the procedure and at 7 days, 1 month, and 3 months after. The goa…

This study tests a gentle, non-invasive brain stimulation technique called alpha tACS in 5 adults who have been in a minimally conscious or vegetative state for 3-12 months after a traumatic brain injury. The goal is to see if repeated sessions can improve their level of awarenes…

This small pilot study is testing whether injections of a person's own platelet-rich plasma (PRP) can improve smell in adults who have had a reduced or lost sense of smell for more than six months due to aging or injury. Thirty participants will receive three PRP injections over …

This study tests whether psychological support—individual therapy, group sessions, or a mix—can improve quality of life and reduce anxiety in women with endometriosis. Forty participants will be randomly assigned to one of four groups, including a no-intervention control. The goa…

This study tests if starting a personalized exercise program early can prevent or reduce the joint pain that many breast cancer patients get from hormone therapy (aromatase inhibitors). About 182 postmenopausal women with hormone-sensitive breast cancer will be randomly assigned …

This study tests whether taking probiotics can reduce common stomach issues like nausea, diarrhea, and belly pain caused by GLP-1 weight-loss drugs (semaglutide or tirzepatide). About 50 adults with obesity will receive either probiotics or a placebo for 24 weeks. The goal is to …

This study tests a new care pathway for adults with severe hearing loss who get a cochlear implant. Instead of many in-person visits, patients will use remote monitoring and have their device activated earlier using data from surgery. The goal is to see if this approach improves …

This study follows 15 people with 7q11.23 microduplication syndrome (a rare genetic condition) to track how social skills develop over time. Researchers will use interviews, questionnaires, and developmental tests to understand the pattern of social difficulties from early childh…

This study compares three methods for inserting wires during pacemaker or defibrillator implantation: two ultrasound-guided techniques and one traditional dissection method. Researchers want to see which approach is fastest and has the fewest complications. About 900 adults getti…

This study looks at how people with Down syndrome or Fragile X syndrome decide who to trust. Researchers will use computer tasks and eye-tracking to measure how participants judge faces, behaviors, and whether someone is being honest. The goal is to understand the thinking patter…

This study looks at whether having just one altered copy of the CYP24A1 gene (instead of two) makes people more likely to develop kidney stones. Researchers will compare 45 people with one or two altered gene copies to understand their health and lab results. The goal is to clari…

This study looks at whether certain immune cells (MAIT cells) play a role in hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Researchers will compare blood and skin samples from 45 adults with HS to those with other skin conditions. The goal is to u…

This study aims to better understand rare autoinflammatory diseases, which cause repeated fevers, rashes, and joint pain due to an overactive immune system. Researchers will develop lab tests using blood samples from 60 patients (adults and children aged 4 and up) to measure infl…

This study aims to see if a two-step screening program helps find advanced liver scarring in people with type 2 diabetes. About 1,714 adults will first get a blood test, and if results are high, a liver scan. The goal is to catch serious liver disease early and connect patients t…

This study looks at whether giving older hospital patients an educational leaflet about benzodiazepines (medicines for sleep or anxiety) changes their attitudes toward reducing or stopping these drugs. About 96 geriatric patients who already take benzodiazepines long-term will an…

This study looks at whether gut bacteria in people with fatty liver disease (MASLD) produce certain chemicals that may harm the liver. Researchers will collect stool samples from 24 participants (patients and healthy volunteers) and grow the bacteria in the lab to measure these c…

This study looks at how epilepsy changes certain brain areas that control breathing and waking up. Researchers will use special brain scans to compare 50 people with drug-resistant epilepsy to healthy volunteers. The goal is to understand why some epilepsy patients may stop breat…

This study is for adults with recurrent meningiomas that have not responded to surgery or radiation. Researchers will use a special PET scan to see if these tumors have a marker called PSMA. If enough tumors show this marker, it could lead to a new targeted radiation therapy for …

This study aims to understand how a specific part of the brain's chemical system (the noradrenergic system) changes with healthy aging and in Parkinson's disease. Researchers will use advanced PET and MRI scans to take detailed pictures of the brain in 165 volunteers, including h…

This study tests a new way to measure fetal bowel brightness on ultrasound more accurately. Currently, doctors rely on a subjective impression, which can lead to false alarms and unnecessary worry for parents. The study will compare standard and adjusted ultrasound settings in 50…

This study looks at why over a third of people treated for obstructive sleep apnea still feel very sleepy during the day, raising their risk of accidents. Researchers will measure oxygen drops during sleep and compare them to results from a standard alertness test. They will also…

This study is testing a new set of tasks called the ExéSem battery to help doctors tell apart two types of language problems in people with Alzheimer's disease, vascular dementia, or primary progressive aphasia. The battery measures how well someone can name objects and understan…

This study checks on children who had a moderate to severe head injury years ago to see if they have lasting hormone problems. Researchers will call about 90 participants from an earlier study in Lyon, France, to ask about their growth and any symptoms. The goal is to understand …

This study tests whether a special camera can capture useful color and brightness details from the brain during neurosurgery. The goal is to help surgeons better tell apart healthy and diseased tissue, or spot active brain areas, beyond what the naked eye can see. About 50 adults…

This study looks at how the brain manages the 'little voice' inside our heads, known as inner speech. Researchers will use brain scans (fMRI) to compare people who have inner speech with those who don't (aphantasics). The goal is to understand which brain areas control inner spee…

This study looks at why people with polycythemia vera, a rare blood disorder, have trouble exercising. Researchers will measure blood thickness and oxygen levels during exercise tests in 54 patients. The goal is to understand the causes of exercise intolerance to help tailor phys…

This study looks at whether the types of viruses found in the airways and gut of very preterm babies (born before 30 weeks) influence their risk of developing bronchopulmonary dysplasia (BPD), a serious chronic lung disease. Researchers will collect samples from 40 babies over th…

This study looks at how the bacteria in the gut and mouth are linked to nutrition in people with digestive cancer starting chemotherapy. Many cancer patients struggle with malnutrition, which can make treatment harder. By collecting stool and saliva samples, along with questionna…

This study looks at how energy production inside cells (mitochondria) works in people with cystinosis, a rare genetic disease that causes cystine buildup and early aging. Researchers will compare blood cells from 25 cystinosis patients with healthy cells to find clues about bone …

This study looks at a hormone called relaxin in women who become pregnant after embryo transfer. Researchers want to see if relaxin levels differ between fresh and frozen embryo transfers, which may help explain why frozen transfers have higher risks of problems like preeclampsia…

This study looks at how cancer and its treatments change the way patients experience food, including taste, appetite, and enjoyment of eating. Researchers will survey 180 adults with breast, head and neck, gynecologic, gastrointestinal, or lung cancer to understand which factors …