Breath sniff test could spot COVID and flu in hospital patients
NCT ID NCT07352462
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a lab. The goal is to see if this painless, non-invasive method can accurately tell bacterial from viral infections, potentially speeding up diagnosis and treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Volatile organic compounds (VOC) analysis in exhaled breath using GC-MS
- What this could lead to
- If successful, this could lead to a quick, painless breath test to diagnose serious respiratory infections, helping doctors choose the right treatment faster.
- What could go wrong
- This is an early observational study, not a treatment trial. The breath test may not be accurate enough to replace current diagnostic methods, and results may vary across different infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 777 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years old * Having signed a written informed consent * Presenting a NEWS-2 score of 5 (\>4) or one of the individual score criteria rated 3 * Hospitalized in one of the HCL (Hospices Civils de Lyon) departments participating in the study * With clinical signs of acute respiratory infection, or with a clinical presentation of acute community-acquired pneumonia, nasopharyngitis, angina or laryngitis (except for healthy patients) Exclusion Criteria: * Healthy volunteers: * Age: \< 18 years * Alcohol consumption less than 12 hours * Person with co-morbidities such as chronic respiratory failure, type II diabetes, cancerous processes, chronic liver disease, chronic kidney disease * Clinical signs of acute respiratory infection * Persons who are unable to blow into exhaled-air analysis devices (in accordance with instructions for use) * Persons under legal protection * Pregnant women, women in labor or nursing mothers * Persons deprived of their liberty by judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults under legal protection (guardianship, curatorship) * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme * Patients with respiratory symptoms * Age: \< 18 years * Patients whose symptoms have been present for more than 7 days * Persons unable to blow into the device for breath analysis (in accordance with the operating instructions) * Patients suffering from cystic fibrosis * Patients with severe chronic respiratory insufficiency requiring long-term oxygen therapy or NIV (non-invasive ventilation), excluding CPAP (Continuous Positive Airway Pressure) for sleep apnea * Patients under legal protection * Pregnant women, women in labor or nursing mothers * Persons deprived of their liberty by judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults under legal protection (guardianship, curatorship) * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
7 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Emergency department (Hôpital de la Croix-Rousse, Hospices Civils de Lyon)
Lyon, 69004, France
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Infectious Disease Service of Hôpital de la Croix-Rousse (Hospices Civils de Lyon)
Lyon, 69004, France
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Intensive Care Unit of Hôpital Lyon Sud (Hospices Civils de Lyon)
Lyon, 69004, France
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Intensive Care Unit of Hôpital de la Croix-Rousse (Hospices Civils de Lyon)
Lyon, 69004, France
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Internal Medecine Unit of Hôpital de la Croix-Rousse (Hospices Civils de Lyon)
Lyon, 69004, France
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National reference center for respiratory viruses (Hôpital de la Croix-Rousse, Hospices Civils de Lyon)
Lyon, 69004, France
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Pneumology Unit of Hôpital de la Croix-Rousse (Hospices Civils de Lyon)
Lyon, 69004, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Does COVID-19 hide in the gut? scientists probe stool for clues
- Blood samples and health records could reveal why some COVID-19 cases turn severe
- Home antibody tests put to the test: can you read your own COVID-19 result?
- Can lung ultrasound reveal COVID-19's signature in the lungs?
- When the immune system Can't fight back: tracking three respiratory viruses
- The household maze: how does COVID-19 move between family members?