New brain scanner could sharpen epilepsy surgery targeting
NCT ID NCT07281222
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new, more comfortable brain scanner (OPM MEG) that fits directly on the head to locate where seizures start in people with epilepsy. Researchers will compare its accuracy to standard methods in 70 patients aged 6 to 65 who are already scheduled for epilepsy surgery. If the device proves reliable, it could help surgeons remove the right brain area and improve seizure control.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- OPM MEG device (FYNA Research)
- What this could lead to
- If successful, this could provide a more accurate, comfortable, and accessible way to pinpoint seizure origins, potentially improving surgical outcomes for epilepsy patients.
- What could go wrong
- This is an early-stage diagnostic study with only 70 participants. The device may not prove more accurate than existing methods, and results may not generalize to all epilepsy types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients aged 6 to 65 2. Patients suffering from partial epilepsy that has been developing for at least 2 years, drug-resistant, regardless of the presumed topographical origin or suggested cause (lesional with or without MRI abnormality) and for whom the following have been decided and planned: either i) a surgical procedure to resect the epileptogenic zone without prior intracranial EEG recording or ii) intracranial EEG recording necessary before a possible cortical resection procedure 3. Patients who have undergone routine prolonged scalp video EEG recording showing interictal paroxysmal abnormalities 4. Patients motivated to participate effectively in the project 5. Patients who have signed an informed consent form to participate in the study Exclusion Criteria: 1. Patients with neurological or psychiatric disorders or a history of neurological or psychiatric disorders, sleep disorders other than epilepsy that may impact the variability or quality of the data or the cooperation and retention of the participant, which will be assessed by the principal investigator or co-investigator during the inclusion interview. 2. Patients with contraindications common to MEG and MRI examinations: * Metal in the body that is incompatible with the examination (pacemaker, implanted pump including insulin pump, neurostimulator, cochlear implants or other hearing devices, metal prosthesis, intracerebral/surgical clips for aneurysms, implantable defibrillators, ferromagnetic foreign bodies in the eyes or brain in the upper body, ventriculoperitoneal neurosurgical shunt valves, dental braces or steel pivots for dental root canals, ferromagnetic foreign bodies in the upper body) * Claustrophobia 3. Pregnant women, breastfeeding women, or women who have given birth within the last 6 months. 4. Patients under guardianship, curatorship, or judicial protection 5. Patients deprived of their liberty 6. Patients not affiliated with a social security system or beneficiaries of such a system
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Service Explorations Fonctionnelles Pédiatriques
Bron, 69500, France
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Hôpital Neurologique, Hospices Civils de Lyon, Service Explorations Fonctionnelles Neurologiques et Epileptologie
Bron, 69500, France
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Hôpital de la Timone, AP-HM Service d'Epileptologie et Rythmologie Cérébrale
Marseille, 13005, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can lavender and lullabies help kids with epilepsy sleep better?
- Reading the Brain's signals to predict who benefits from deep brain stimulation
- Can a Comfort-Focused education program improve life with epilepsy?
- Can video games rewire young brains after injury?
- High-Fat Diet's effect on epilepsy: scientists track brain signals
- Epilepsy drug candidate put to the test in healthy volunteers