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Scientists investigate why cystinosis causes early aging

NCT ID NCT07319091

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study looks at how energy production inside cells (mitochondria) works in people with cystinosis, a rare disease that causes cystine buildup and early aging. Researchers will measure cell energy activity in 25 patients and compare it to healthy people. The goal is to understand why cystinosis leads to bone disease and other complications, which could help find new treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could uncover the biological causes of premature aging and bone disease in cystinosis, pointing toward new treatment targets.
What could go wrong
This is a small, early observational study (25 participants) that measures cellular activity, not a treatment trial. It may not lead directly to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with genetically confirmed nephropathic cystinosis * Men and women, children and adults with cystinosis * Undergoing conservative treatment on native kidneys * Age ≥ 2 years * Patients receiving oral cysteamine * Patients with social security coverage * Informed consent signed by the participant or parents or legal guardians before participating in the study Exclusion Criteria: * Patient not complying with study procedures * Transplant or dialysis patient * Patient on anticalcineurin * Pregnant or breast-feeding woman * Person deprived of liberty by a judicial or administrative decision * Person not affiliated to a social security scheme or beneficiaries of a similar scheme

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Conditions

The condition(s) this trial relates to.

cystinosis muscle tissue disorder nephropathic cystinosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cystinosis Native kidney

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    9 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Service de Néphologie et endocrinologie pédiatrique, Hôpital Arnaud de Villeneuve

    RECRUITING

    Montpellier, 34295, France

  • Service de Néphrologie pédiatrique, Hôpital Jeanne de Flandre

    RECRUITING

    Lille, 59000, France

  • Service de Néphrologie pédiatrique, Hôpital Necker-Enfants Malades

    RECRUITING

    Paris, 75015, France

  • Service de Néphrologie pédiatrique, Hôpital Robert Debré

    RECRUITING

    Paris, 75019, France

  • Service de Néphrologie pédiatrique, Hôpital de la Timone

    RECRUITING

    Marseille, 13385, France

  • Service de Néphrologie-Dialyse-Transplantation pédiatrique, Hôpital d'enfants Brabois

    RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • Service de Néphrologie-transplantation rénale adultes, Hôpital Necker-Enfants Malades

    RECRUITING

    Paris, 75015, France

  • Service de néphrologie et exploration fonctionnelle rénale, Hôpital Edouard Herriot, Hospices Civils de Lyon

    RECRUITING

    Lyon, 69003, France

  • Service de néphrologie pédiatrique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon

    RECRUITING

    Bron, 69677 Bron Cedex, France

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