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Could a blood pressure cuff help fight septic shock?

NCT ID NCT07273942

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive arm cuff procedure, called remote ischemic postconditioning, can reduce deaths in adults with septic shock. The cuff is inflated and deflated in cycles to briefly restrict blood flow, which may trigger protective effects. 720 ICU patients will be randomly assigned to receive the procedure or standard care, and survival at 90 days will be compared.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote ischemic conditioning (arm cuff inflation/deflation cycles)
What this could lead to
If it works, this could offer a simple, cheap, non-invasive way to reduce deaths from septic shock.
What could go wrong
This is a large trial but still early for this specific condition. Previous benefits seen in other diseases may not apply to septic shock, and the intervention may have no effect on survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 720 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Hospitalized in intensive care unit for less than 24 hours * Septic shock (Sepsis-3 definition) evolving for less than 18 hours * Preliminary written informed consent obtained from the patient or his/her close relative, or use of the emergency procedure in accordance with local regulations Exclusion Criteria: * Contraindication of the use of a brachial pressure cuff on both arms * Cardiac arrest * Pregnancy or breast feeding * Participation in another interventional study * Lack of French national health insurance coverage * Patient with any legal protection measure

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Conditions

The condition(s) this trial relates to.

toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adult patients with septic shock admitted in intensive care unit

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    23 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Service Réanimation Polyvalente, Centre Hospitalier de Fleyriat

    Bourg-en-Bresse, 01012, France

  • Service Réanimation Polyvalente, Centre Hospitalier de Roanne

    Roanne, 42328, France

  • Service Réanimation Polyvalente, Hôpital Saint-Joseph Saint-Luc

    Lyon, 69007, France

  • Service d'Anesthésie - Réanimation - Médecine Intensive, Hôpital Lyon Sud, Hospices Civils de Lyon

    Pierre-Bénite, 69495, France

  • Service de Médecine Intensive - Réanimation, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris

    Paris, 75014, France

  • Service de Médecine Intensive et Réanimation Polyvalente, Hôpital Robert Debré, CHU Reims

    Reims, 51090, France

  • Service de Médecine Intensive- Réanimation, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand

    Clermont-Ferrand, 63003, France

  • Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, Assistance Publique des Hôpitaux de Paris

    Le Kremlin-Bicêtre, 94270, France

  • Service de Médecine Intensive-Réanimation, Hôpital Bretonneau, CHRU de Tours

    Tours, 37000, France

  • Service de Médecine Intensive-Réanimation, Hôpital Central, CHRU de Nancy

    Nancy, 54035, France

  • Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon

    Lyon, 69003, France

  • Service de Médecine Intensive-Réanimation, Hôpital Henri Mondor, Assistance Publique des Hôpitaux de Paris

    Créteil, 94000, France

  • Service de Médecine Intensive-Réanimation, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille

    Marseille, 13015, France

  • Service de Médecine Intensive-Réanimation, Hôpital Salengro, CHU de Lille

    Lille, 59037, France

  • Service de Médecine Intensive-Réanimation, Hôtel Dieu, CHU de Nantes

    Nantes, 44093, France

  • Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, CHU de Strasbourg

    Strasbourg, 67091, France

  • Service de Médecine intensive-Réanimation, Hôpital Lapeyronie, CHU de Montpellier

    Montpellier, 34295, France

  • Service de Médecine intensive-Réanimation, Hôpital Nord, CHU de St Etienne

    Saint-Priest-en-Jarez, 42270, France

  • Service de Médecine intensive-Réanimation,Hôpital Albert Michallon, CHU de Grenoble

    La Tronche, 38700, France

  • Service de Médecine intensive-Réanimation,Hôpital F Mitterrand, CHU de Dijon

    Dijon, 21079, France

  • Service de Réanimation Médicale, Hôpital Jean-Minjoz, CHU de Besançon

    Besançon, 25030, France

  • Service de Réanimation des Urgences, Hôpital de la Timone, CHU de Marseille

    Marseille, 13385, France

  • Service des maladies infectieuses et réanimation médicale, Hôpital Pontchaillou, CHU de Rennes

    Rennes, 35000, France