Breathalyzer could replace PCR for respiratory infections
NCT ID NCT07348380
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer a faster, easier alternative to nasal swab PCR tests.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,665 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Eligibility Criteria \* * Inclusion Criteria \* : * Age ≥ 18 years old * Having signed a written informed consent * With clinical signs of acute respiratory infection, or with a clinical presentation of acute community-acquired pneumonia, nasopharyngitis, angina or laryngitis (except for healthy patients) * Exclusion Criteria \* : * Healthy volunteers: * Age: \< 18 years * Alcohol consumption less than 12 hours * Person with co-morbidities such as chronic respiratory failure, type II diabetes, cancerous processes, chronic liver disease, chronic kidney disease * Clinical signs of acute respiratory infection * Persons who are unable to blow into exhaled-air analysis devices (in accordance with instructions for use) * Persons under legal protection * Pregnant women, women in labor or nursing mothers * Persons deprived of their liberty by judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults under legal protection (guardianship, curatorship) * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme * Patients with respiratory symptoms * Age: \< 18 years * Patients whose symptoms have been present for more than 7 days * Persons unable to blow into the device for breath analysis (in accordance with the operating instructions) * Patients suffering from cystic fibrosis * Patients with severe chronic respiratory insufficiency requiring long-term oxygen therapy or NIV (non-invasive ventilation), excluding CPAP (Continuous Positive Airway Pressure) for sleep apnea * Patients under legal protection * Pregnant women, women in labor or nursing mothers * Persons deprived of their liberty by judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults under legal protection (guardianship, curatorship) * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Emergency department (Hôpital de la Croix-Rousse, Hospices Civils de Lyon) Lyon (France) 69004
Lyon, 69004, France
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Maison de Santé Pluriprofessionnelle Universitaire (Hôpital de la Croix-Rousse, Hospices Civils de Lyon)
Lyon, 69004, France
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National reference center for respiratory viruses (Hôpital de la Croix-Rousse, Hospices Civils de Lyon)
Lyon, 69004, France