Blood filtering shows promise for severe COVID-19 breathing problems

NCT ID NCT04751643

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 29 times

Summary

This study tested a treatment called therapeutic plasma exchange (TPE) for people with severe COVID-19. TPE filters the blood to remove harmful inflammatory substances that can cause breathing failure. The study compared standard intensive care alone to standard care plus TPE in 21 adults. The goal was to see if TPE could reduce the need for a breathing tube and improve oxygen levels.

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Contacts and locations

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Locations

Centre Hospitalier Lyon Sud

Pierre-Bénite, 69310, France
Centre Hospitalier William Morey

Chalon-sur-Saône, 71100, France
Clinique de la Sauvegarde

Lyon, 69337, France
Groupement Hospitalier Porte de Valence - Montélimar

Montélimar, 26216, France
Hôpital Croix Rousse

Lyon, 69004, France
Hôpital Edouard Herriot

Lyon, 69003, France
Hôpital Pitié Salpétrière - Assistante Publique des Hôpitaux de Paris

Paris, 75013, France
Medipole Villeurbanne

Villeurbanne, 69100, France

Conditions

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ARDS, HUMAN COVID19 COVID19 INTENSIVE CARE UNITS INTENSIVE CARE UNITS