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Can a simple blood test predict which flu patients will need a breathing machine?

NCT ID NCT02392858

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to study gene activity in severely ill patients. The goal is to find early warning signs so doctors can act faster.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify which flu patients are at highest risk of severe breathing failure, allowing earlier and more targeted care.
What could go wrong
This is an observational study, not a treatment trial. The biomarker may not prove reliable enough for routine use, and results may not apply to all flu patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

227 people

The number who actually took part.

Started

Jan 2015

Finished

Jan 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 month to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient (Adult or Pediatric) * Hospitalized in reanimation * With a laboratory confirmed Influenza * That agree to take part in the study * Affiliated to National Health Insurance For ancillary group : * Adult at least 60 years old * Presenting at hospital for a blood test Exclusion Criteria: * non willing to participate * Influenza infection with no respiratory symptoms * pregnancy For ancillary group : * Presence of immunodepression defined by: * Cancer, or cancer cured for less than 2 years * Corticosteroids, Methotrexate (MTX), anti Tumor Necrosis Factor (TNF), anti-CD20 * Infection in progress (fever)

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Conditions

The condition(s) this trial relates to.

influenza respiratory tract infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Influenza Severe respiratory infection

Contacts and locations

Locations

  • CHU Service de Réanimation Adulte

    Saint-Etienne, France

  • CHU Service de Réanimation Pédiatrique

    Saint-Etienne, France

  • CHU service réanimation adulte

    Clermont-Ferrand, France

  • CHU service réanimation adulte

    Dijon, France

  • CHU service réanimation adulte

    Grenoble, France

  • CHU service réanimation pédiatrique

    Clermont-Ferrand, France

  • CHU service réanimation pédiatrique

    Dijon, France

  • CHU service réanimation pédiatrique

    Grenoble, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, France

  • Centre de Biologie et Pathologie Est

    Lyon, France

  • Centre de Biologie et de Pathologie Nord

    Lyon, Auvergne-Rhône-Alpes, 69500, France

  • Hôpital Edouard Herriot

    Lyon, France

  • Hôpital Femme Mère Enfant

    Bron, France

  • Hôpital de la Croix Rousse-service réanimation adulte chirurgicale

    Lyon, France

  • Hôpital de la Croix Rousse-service réanimation adulte médicale

    Lyon, France

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