INFLUENZA

This study tests a new flu vaccine in 150 healthy pregnant women aged 18 to 39 who are 20 to 32 weeks along. Half get the new vaccine, the other half a standard one. Researchers check blood samples before and after vaccination to see how well the vaccine works and if it safely pa…

This study tests a new mRNA vaccine (mRNA-1018-H5) designed to protect against a potential H5N1 bird flu pandemic. About 4,000 healthy adults aged 18 and older will receive two doses of the vaccine or a placebo. Researchers will measure the immune response and monitor for side ef…

This study compares a high-dose flu vaccine to the standard-dose vaccine in children aged 3-17 who have received a kidney, heart, or liver transplant within the past 2 years. The goal is to see if the high-dose vaccine provides better protection against the flu without causing mo…

This study tests a new flu vaccine in 120 adults aged 60 and older. Participants are randomly assigned to receive either the new vaccine, a standard flu vaccine, or a placebo. The goal is to check the vaccine's safety and how well it triggers an immune response.

This study tests a new flu vaccine made from plants in about 728 adults aged 18 and older. The goal is to see if it is safe and triggers a strong immune response compared to a standard flu shot. Results will help choose the best dose for future studies.

This study tests an experimental flu vaccine called BPL-1357 in 129 healthy adults aged 18 to 55. The vaccine is given as a shot or nasal spray, and participants are later exposed to flu virus in a controlled setting to see if the vaccine prevents illness. The goal is to find a v…

This study tests three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma, including those who had a stem cell transplant or CAR-T therapy. The goal is to see which vaccine triggers the strongest immune response. Results will help doctors choose the …

This early-stage study tests whether an experimental oral drug called VNT-101 is safe in healthy adults aged 18 to 59. About 78 participants will receive either the drug or a placebo, with some taking a single dose and others taking multiple doses over several days. The goal is t…

This study looks at whether a high-dose flu vaccine given over two years works better than the standard-dose vaccine for lung transplant recipients. These patients have weakened immune systems due to lifelong anti-rejection drugs, making them very vulnerable to flu. The goal is t…

This study compares different antiviral drugs for early flu in adults aged 18-60. Participants must have flu symptoms for less than 4 days and test positive. The goal is to see which drug clears the virus fastest from the nose and throat.

This study tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for treating severe flu in people who have had a stem cell transplant or have blood cancer. About 60 participants will be followed for 30 days to see if the comb…

This study looks at how well the flu medicine baloxavir marboxil works in children under 12 and whether it stops the flu from spreading to family members. About 1,100 kids with flu symptoms will take the medicine, and researchers will check for drug resistance and track if househ…

This study compares a high-dose flu vaccine to the standard dose in 270 lung transplant recipients who are 1 to 35 months post-transplant. The goal is to see if the high-dose vaccine triggers a stronger immune response and provides better protection against the flu. Participants …

This study tests a new program to increase flu vaccination rates among children admitted to hospitals. Researchers will work with doctors, nurses, and families to create a simple process for offering flu shots during a hospital stay. The goal is to protect more kids from the flu …

This study tests whether giving antiviral drugs to uninfected hospital roommates of flu patients can prevent them from catching the flu. About 384 participants will be randomly assigned to receive either a placebo, suraxavir marboxil, or oseltamivir. The goal is to see which drug…

This study looks at whether taking IDP supplement daily can make cold and flu symptoms less severe and shorter in people aged 60 and older. About 300 participants will take either the supplement or a placebo and report their symptoms using a smartphone app. The goal is to see if …

This study tests a higher-dose version of the antiviral drug Ingavirin (called Ingavirin Forte) in 300 adults with confirmed flu or other viral colds. The goal is to see if it shortens how long symptoms like fever, runny nose, sore throat, cough, and body aches last. Participants…

This study intentionally gives healthy adults a mild flu infection to learn how the immune system fights the virus and how the virus spreads. Researchers will monitor symptoms and safety closely. The goal is to gather knowledge, not to test a treatment or vaccine.

This study collects nose, blood, and saliva samples from 20,000 people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The goal is to learn more about these viruses and how the body fights them. Samples will be stored for future research, including…

This study looks at whether community health workers can share true health information on social media using personal stories. About 1,400 health workers and their followers will take part. The goal is to see if this approach helps people decide to get vaccines and protect themse…

This study aims to find the right dose of a specific flu virus that safely causes mild flu symptoms in healthy adults aged 18 to 55. About 90 volunteers will receive either the virus or a sham (placebo) and be closely monitored. The goal is to create a reliable human infection mo…

This study looks at how the immune system responds to the flu, either from a nasal spray vaccine or a controlled infection with a lab-made flu virus. Healthy adults aged 18-55 will be split into two groups to compare symptoms and immune reactions. The goal is to better understand…

This study screens healthy adults aged 18 to 65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a 3-5 hour checkup including blood tests, heart test, and chest X-ray. No treatment is given; the goal is to build a pool of eligib…

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track things like temperature, heart rate, coughing, and voice changes. The goal is to see if these devices can detect …

This study looks at how the immune system responds to flu and COVID-19 vaccines over a full year. About 150 NIH staff members who plan to get these vaccines will provide monthly blood and nasal samples. No vaccines are given as part of the study; it only observes natural immune c…

This study looks at how COVID-19 treatments and vaccines have been used in the VA healthcare system and how well they work. Researchers will study data from up to 400,000 Veterans to compare treatments like Paxlovid and remdesivir, and also look at RSV and flu. The goal is to lea…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to see if catching flu, COVID-19, or other respiratory viruses raises the risk of problems like preterm labor or severe preeclampsia. The goal is to gathe…

This study looks at how breathing in woodsmoke changes the way your nose's immune system reacts to the flu virus. Healthy adults aged 18-49 will be exposed to woodsmoke and then given a live but weakened flu vaccine to see how their nasal immune responses change. The goal is to u…

This study looks at how the immune system of adults over age 75 responds to the annual flu vaccine. Researchers want to know if a common virus called CMV affects how well the vaccine works. About 1,025 healthy or frail older adults will join, and they will receive the flu shot fo…

This study aims to learn how the immune system fights the flu and how the virus spreads. Up to 50 healthy adults aged 18-49 will receive a nasal spray containing a specific flu virus (H3N2) and stay in the hospital for 8-12 days for close monitoring. The goal is to use this infor…

This study tests a web-based educational program called InTroDuce-Programme for pregnant women. The goal is to see if it improves their knowledge about flu and Tdap vaccines and increases their intention to get vaccinated. About 351 pregnant women in Malaysia will take part, with…

This study looks at the best way to give COVID-19 booster and flu vaccines to people with weakened immune systems, such as those with rheumatoid arthritis, HIV, or organ transplants. Researchers will compare giving both vaccines at the same time versus one month apart, and also t…

This study looks at whether drinking pasteurized milk containing killed (inactive) H5 flu virus particles could lead to a positive flu test from nose or throat swabs. The virus pieces are harmless and cannot cause illness. Researchers want to help the CDC understand if milk consu…

This study looks at how the immune system reacts to influenza and COVID-19 in people with symptoms. Researchers will compare those who got a flu or COVID vaccine in the past year with those who did not. About 300 participants will provide blood, saliva, and nasal samples over 6 m…