INFLUENZA

This study is testing a new mRNA vaccine designed to protect against a potential bird flu (H5N1) pandemic. It will enroll 4,000 healthy adults to see if the vaccine safely triggers a strong immune response after two doses. Researchers will compare results against a placebo to see…

This study is testing a new seasonal flu vaccine made using plant-based technology. It aims to see if the vaccine is safe, well-tolerated, and triggers a good immune response in adults. The trial will compare different doses of the new vaccine against a standard, commercially ava…

This study is testing the safety and immune response of a new influenza (flu) vaccine in healthy adults aged 60 and older. It will enroll 120 participants to receive either the new vaccine, an existing vaccine, or a placebo shot. The main goal is to see how safe the new vaccine i…

This study is testing a new four-strain flu vaccine to see if it is safe and effective for pregnant women. It will enroll 150 healthy pregnant women in their second or third trimester. Researchers will compare the new vaccine to an existing one and check if protective antibodies …

This study has two main goals. First, it checks if the flu virus in children under 12 becomes resistant to a common flu medicine called baloxavir. Second, it watches to see if the flu spreads from these treated children to other people living in their home. The study is recruitin…

This study is testing if giving two antiviral drugs together (baloxavir and oseltamivir) works better than the standard single drug (oseltamivir) to treat severe influenza. It is for people with blood cancers or who have had a stem cell transplant, as their weakened immune system…

This Oxford University study compares how well seven different antiviral drugs work against the flu. It will enroll 3,000 adults who have just gotten sick with the flu to see which medicines clear the virus fastest and help people feel better sooner. Some participants will receiv…

This study aims to find the best way to give COVID-19 booster shots and seasonal flu vaccines to adults with weakened immune systems. Researchers want to know if getting both shots on the same day works as well as getting them a month apart, and if getting COVID boosters every 3 …

This study aims to see if giving stronger (high-dose) flu vaccines over two consecutive years provides better protection against influenza for people who have received a lung transplant. It will compare the immune response and safety of the stronger vaccine to the standard one in…

This study is testing whether a higher-dose flu vaccine given twice in one season is more effective than the standard dose for people who have received a lung transplant. Lung transplant recipients are at high risk for severe flu because their anti-rejection medications weaken th…

This study aims to find the most effective flu vaccine for adults with blood cancers, who have a much higher risk of severe flu complications. Researchers are testing three different flu shot formulas to see which one produces the strongest immune response in these patients with …

This study is testing whether a daily dietary supplement called IDP can help reduce the severity and shorten the duration of cold and flu symptoms in adults aged 60 and older. About 300 participants will take either the real supplement or a placebo (a look-alike with no active in…

This study is testing if a new, stronger dose of a medication called Ingavirin Forte can help adults with the flu or a common cold feel better faster. Researchers will compare how quickly symptoms like fever, cough, and sore throat go away in people taking the new dose versus a s…

This study aims to learn how the body's immune system responds to the flu and how the virus spreads. Healthy adult volunteers will be intentionally exposed to a specific flu strain in a controlled hospital setting and closely monitored. The information gathered will help research…

This study aims to directly compare how the body responds to two different FDA-approved COVID-19 vaccines: the Novavax protein-based vaccine and the Pfizer mRNA vaccine. Researchers will enroll 54 adults with certain health conditions who are eligible for vaccination. The study w…

This is the first study in humans to test a new oral medication called VNT-101, which is being developed to treat influenza (flu). Researchers will give the drug to about 78 healthy adults to see how safe it is and how the body processes it at different single and multiple doses.…

This study aims to understand how well the immune systems of adults over age 75 respond to the annual flu shot. Researchers want to see if a common, lifelong virus called CMV affects how well the vaccine works in this age group. The study involves giving participants a free flu s…

This study aims to understand how infections with COVID-19, influenza, and other respiratory viruses during pregnancy affect the health of mothers and their babies. Researchers will follow 10,000 pregnant women in India from early pregnancy through the weeks after birth, tracking…

This study aims to collect samples from people with respiratory virus infections like the flu or COVID-19. Researchers will store these samples in a repository to be used in future research. The goal is to learn more about how these viruses work and how our bodies fight them, whi…

This study aims to create a safe and reliable model for testing future flu medicines and vaccines. Healthy adult volunteers are intentionally given a specific strain of the flu virus to find the dose that reliably causes mild illness. Researchers will closely monitor participants…

This study aims to screen healthy adults to create a pool of volunteers for future research on infectious diseases like influenza (flu) and Zika virus. Researchers will collect health information and samples from up to 5,000 participants to quickly identify eligible people for up…

This study aims to understand why getting a flu shot every year might make it less effective for some people. Researchers will follow 600 healthy adults in Hong Kong, giving them different combinations of flu shots and nasal spray vaccines over two years to see how their immune s…

This study aims to understand how the body's immune system responds and changes over time after receiving the seasonal flu vaccine and/or a COVID-19 vaccine. Researchers will follow about 150 adult NIH staff members for roughly a year, collecting monthly blood and nasal samples. …

This study aims to understand how different types of FDA-approved seasonal flu vaccines affect the body's immune response, specifically the antibodies and cells that fight the flu. Researchers will compare these responses in two groups: healthy adults aged 18-50 and adults aged 6…

This study aims to see if data from smartwatches and smartphones can detect early, subtle signs of respiratory virus infections like flu and coronavirus. Researchers will monitor 1,000 healthy adults who are already participating in separate virus exposure studies, tracking their…

This study aims to see if drinking pasteurized milk containing inactive H5 bird flu particles leads to the virus being detected in nose or throat swabs. Healthy adults will drink a small amount of specially prepared milk and provide swab samples. The results will help public heal…

This study aims to better understand how common respiratory viruses like the flu, RSV, and COVID-19 spread among children. Researchers will track 500 children under 18 who test positive for one of these viruses, along with their household and classroom contacts. The goal is to le…

This study is testing a new way to share trustworthy health information online. Researchers are training community health workers in seven high-risk neighborhoods to post personal stories about flu and COVID-19 protection on their social media. The goal is to see if these persona…

This large study analyzes health records from 400,000 U.S. veterans to understand how well different COVID-19, RSV, and influenza treatments and vaccines work in real-world settings. Researchers will compare who received which medications and track health outcomes like hospitaliz…