Influenza

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

This early-stage trial tests a new influenza vaccine that includes a special booster called BK-01 adjuvant. The goal is to see if it is safe and triggers a strong immune response in adults 18 and older. 160 volunteers will receive either the new vaccine, a standard flu vaccine, o…

Researchers are testing an experimental oral drug called SYH2085 in adults with uncomplicated influenza. The study compares SYH2085 against a placebo to see if it can shorten the time to resolution of flu symptoms like fever, cough, and body aches. Participants must have tested p…

This study tests whether a single oral dose of TRX-100 can prevent influenza infection in healthy adults aged 18 to 55. Participants will be deliberately exposed to the flu virus in a controlled setting. The trial is randomized, double-blind, and placebo-controlled, meaning neith…

This phase 3 trial will test whether adding low or moderate doses of the corticosteroid methylprednisolone to standard care can lower the death rate in adults with severe influenza pneumonia in the ICU. About 496 participants will be randomly assigned to receive either saline (pl…

Researchers are testing whether Sinovac's Anflu flu vaccine produces a strong immune response in pregnant women compared with Sanofi's Vaxigrip. The trial enrolls 150 healthy pregnant women between 22 and 34 weeks of pregnancy. Each participant receives one dose of either vaccine…

This trial tests whether mailed letters, patient portal messages, or texts can encourage flu vaccination among adults with multiple risk factors for severe influenza. Researchers will identify high-risk patients using a simple rule-based scoring system, then send reminders and tr…

This trial tests whether a single combined mRNA vaccine, mCombriax (mRNA-1083), can protect adults aged 65 and older against both influenza and COVID-19 as effectively as getting two separate shots on the same day. Researchers will compare how many participants in each group deve…

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study tests two nasal protective devices (Noseguard and Noseguard Night) in 2000 adults to see if they can reduce the risk of catching respiratory infections like COVID-19 and influenza. Participants will use the devices as directed for 8 weeks, and researchers will track in…

This study tests a new flu vaccine in 1,200 adults aged 60 and older to see how well it boosts immunity and if it's safe. Participants receive one dose of either the new vaccine or a current one, and researchers check antibody levels and side effects for 30 days. The goal is to f…

Researchers at Emory University are running a study to see whether influenza A or B spreads from adults who caught the flu in the community to healthy adults under controlled hospital conditions. Instead of using a lab-made flu strain, the study uses naturally infected donors as …

This follow-up study checks if taking TUDCA or fatty acid supplements during a flu vaccine helps older adults (ages 60-70) keep their immunity longer. Researchers will measure antibody levels and immune cells about 8 months after vaccination. No new treatment is given—just one bl…