INFLUENZA

This early-stage trial tests a new flu vaccine with an added ingredient (adjuvant) to boost immune response. About 160 adults aged 18 and older will receive either the test vaccine, a standard flu vaccine, or a placebo. Researchers will monitor side effects and measure antibody l…

This early-stage trial compares an experimental flu vaccine (H1ssF) with the standard seasonal flu shot (Flucelvax) in 112 adults aged 18-70. Some participants have had flu shots before, while others have never been vaccinated. The main goal is to check safety and how the immune …

This study tests whether an experimental drug called TRX-100 can prevent flu infection in healthy adults aged 18 to 55. Participants will be given the drug or a placebo and then exposed to a controlled dose of influenza A virus. Researchers will measure how many people get infect…

This study tests whether adding corticosteroids to standard care can lower the risk of death in adults with severe flu pneumonia in the ICU. About 496 participants will receive either standard care alone or standard care plus different doses of steroids. The goal is to find a saf…

This study tests two nasal devices (Noseguard and Noseguard Night) to see if they can lower the chance of getting respiratory infections like COVID-19 and the flu. About 2,000 adults will use the devices for 8 weeks, and researchers will track infection rates and how easy the dev…

This study tests a new flu vaccine in 1200 adults aged 60 and older. It aims to see how well the vaccine boosts the body's defenses against the flu and checks for any side effects. Participants will receive one shot and be monitored for 30 days.

This study tests whether a new antiviral pill, onradivir, can help teenagers aged 12 to 17 recover faster from the flu. About 150 teens with uncomplicated influenza A will take either the medicine or a placebo once daily for five days. Researchers will track how quickly symptoms …

This study aims to understand how brain function changes in people with smell disorders, such as loss of smell or distorted smell. Researchers will use brain scans, smell tests, and questionnaires to track these changes over one year. The study involves 80 adults, including healt…

This study will collect nose or saliva samples from up to 25,000 people who visit their doctor with a sudden fever and breathing symptoms during fall and winter. The goal is to track which viruses—like flu, COVID-19, RSV, or rhinovirus—are circulating in the community. The inform…

This study follows up on 30 older adults (ages 60-70) who previously received a flu vaccine with either a supplement called TUDCA, fatty acids, or a placebo. Researchers want to see if TUDCA helped them maintain higher antibody levels and immune memory cells about 8 months after …