INFLUENZA

This study tested a new mRNA-based flu vaccine (mRNA-1010) in 172 healthy adults aged 18-50 and 65-80. The goal was to see if it is safe and triggers a strong immune response compared to standard flu vaccines. Results will help decide if the vaccine should move to larger trials.

This early-stage study tested a new universal influenza vaccine in 144 healthy adults aged 18 to 40. The goal was to check the vaccine's safety and how well it triggers an immune response. Participants received either the vaccine or a placebo, and researchers monitored for side e…

This study tested whether a single shot combining modified RNA vaccines for flu and COVID-19 is safe and works well. About 2,650 healthy adults aged 18 and older received one injection of either a flu vaccine, a COVID-19 vaccine, or both combined. Researchers monitored side effec…

This study tested a new seasonal flu vaccine made from animal cells instead of chicken eggs in over 3,200 adults aged 50 and older. Participants received either the new vaccine or a standard egg-based flu shot, and researchers measured their immune response and side effects. The …

This study tested whether a new method for making the seasonal flu vaccine works as well as the current method and a licensed vaccine. About 1,900 healthy adults aged 18 and older took part. Researchers measured immune responses and checked for side effects to ensure the new vacc…

This study tested an H1N1 flu vaccine in 110 pregnant women to see if it is safe and helps their immune system fight the virus. Participants received two vaccine doses and were monitored for side effects. The goal was to measure antibody levels in the blood and in cord blood at d…

This study tested a new flu vaccine in 2,772 healthy children aged 6 to 35 months. The children received two doses of either the experimental vaccine or a control vaccine, 28 days apart. Researchers checked for side effects and measured the immune response through blood tests. Th…

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. Researchers gave the vaccine or a placebo to 157 healthy adults aged 18–49 and 65–84. The main goal was to check safety and how well the vaccine triggers an immune response. Results will help …

This study tested a new vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 932 adults aged 50 to 64 received the vaccine to check its safety and how well it triggers an immune response. The goal is to see if this combined approach is as effec…

This study tested whether an experimental flu vaccine made in animal cells (instead of eggs) can prevent the flu. About 7,250 adults received either the vaccine or a placebo shot. Researchers tracked who got the flu over 6 months, using nose and throat swabs to confirm infections…

This study tested whether an enhanced flu vaccine (with an adjuvant) produces a stronger immune response than the standard flu shot in healthcare workers. About 192 hospital staff in Peru received either the adjuvanted or standard vaccine. Researchers measured antibody levels at …

This early-stage study tested a single-dose mRNA flu vaccine in 50 healthy adults aged 18 to 49. The goal was to check safety and see how well the vaccine triggers an immune response compared to a standard flu shot. Participants received one of three doses (10, 25, or 50 mcg) or …

This early-stage study tested whether a flu vaccine with an extra H3 virus strain is safe and triggers a strong immune response. About 400 healthy adults aged 18-49 and 60+ received either the experimental vaccine or a standard one. The goal was to see if adding another H3 strain…

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. Around 8,800 healthy adults received either the combo shot or separate vaccines. Researchers checked for side effects and immune response over 6 months. The goal is to make vacci…

This study tested an experimental vaccine against H5N8 bird flu in 1380 healthy adults. The goal was to see how safe the vaccine is and how well it triggers the immune system at different dose levels with two different adjuvants (AS03 and MF59). The results will help determine th…

This study tested whether sending digital reminder letters through Denmark's official electronic system could encourage more adults aged 18-64 with chronic diseases to get their flu shot. Over 308,000 participants were included. The goal was to see if these simple reminders could…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could make them work better. About 240 healthy adults aged 18 to 45 received either a regular flu shot or one with an adjuvant. Researchers checked for side…

This early-stage study tested whether giving a booster shot of an H5N1 flu vaccine to people who had previously received other experimental flu vaccines could create broader, longer-lasting protection. Thirty-two healthy adults took part to see if this 'prime-boost' approach safe…

This study tested whether a quadrivalent (four-strain) flu vaccine works as well as or better than a trivalent (three-strain) flu vaccine. Over 7,000 healthy or medically stable people aged 6 months and older in China took part. Researchers measured immune responses and tracked s…

This study tested two different doses of an experimental H7 bird flu vaccine, each combined with an immune booster (MF59), against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune res…

This study tested a new combination vaccine (mRNA-1083) that targets both COVID-19 and the flu in one shot. About 2,400 healthy adults aged 50 and older in Japan, Taiwan, and South Korea took part. The goal was to see how well the vaccine boosts immunity and whether it is safe, c…

This study tested whether a new seasonal flu vaccine made by Butantan Institute works as well and is as safe as a standard Sanofi vaccine. 632 healthy adults in Brazil received one of the two shots. Researchers measured immune response and tracked side effects like pain, fever, a…

This study compared two types of flu vaccines—one made using eggs and one not—to see which triggers a stronger immune response in adults aged 18 to 64. Researchers followed 366 participants over two flu seasons to measure antibody levels. The goal was to understand if egg-based v…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current shots that target only one or two. Participants received two doses four months ap…

This study tested a new combination vaccine (mRNA-1083) that targets both influenza and COVID-19 in a single shot. About 1,320 healthy adults aged 18 to 64 took part. Researchers measured how well the vaccine boosted immunity and monitored for side effects. The goal is to simplif…

This study tested a new combination vaccine that aims to protect against both the flu and COVID-19 with a single shot. Researchers enrolled 1,758 healthy adults to check the vaccine's safety and how well it triggers the immune system. The goal is to simplify annual vaccinations b…

This study tested whether sending text message reminders to parents could increase flu vaccination rates among children. Over 228,000 kids aged 6 months to 18 years from the Children's Hospital of Philadelphia network took part. Researchers compared vaccination rates 30 days afte…

This study tested whether adding baloxavir to standard oseltamivir treatment helps hospitalized flu patients clear the virus faster. Fifteen adults with confirmed influenza were randomly assigned to receive either the drug combo or oseltamivir alone. The main goal was to measure …

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV from nasal swabs. Over 1,200 people with respiratory symptoms took part. The test was compared to standard lab tests to see if it is accurate and reliable.

This study tested a new medicine called CD388, given as a single set of shots, to see if it can prevent the flu in healthy adults aged 18 to 64. About 5,000 participants received either the study drug or a placebo, and researchers tracked how many got the flu over 24 weeks. The g…

This study tested whether a high-dose flu vaccine works better than the standard-dose vaccine in adults aged 50 to 64. About 1,180 participants received either the high-dose or standard-dose shot, and researchers measured their immune response and safety. The goal is to see if th…

This study compared a high-dose flu vaccine to the regular dose in over 330,000 adults aged 65 and older. The goal was to see if the stronger shot better prevents hospital stays for flu or pneumonia. Participants were randomly assigned to receive either the high-dose or standard-…

This study combined data from two large trials involving over 466,000 older adults to compare the effectiveness of a high-dose flu vaccine versus the standard dose. The goal was to see if the high-dose shot better prevents severe outcomes like hospitalization for flu or pneumonia…

This study compared a single dose of baloxavir marboxil to a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety, including side effects. Researchers also measured how quickly symptoms like cough and fever improved…

This study followed 919 pregnant women in three Paris hospitals during the 2009 H1N1 flu pandemic. Researchers measured how many women got the flu and how it affected their pregnancies and babies. They also tracked the safety of the flu vaccine.

This study looked at 241 adults hospitalized with the flu to understand how the infection affects the heart. Researchers checked for heart problems like heart failure, heart attacks, and abnormal heart function using blood tests and imaging. The goal was to learn more about the l…

This study explored how influenza infection changes the types of bacteria living in the nose and throat, and how the body's immune response relates to those changes. Researchers gave 17 healthy adults either a flu vaccine nasal spray or a saltwater mist, then tracked their bacter…

This study tested whether measuring a protein called MxA in the blood can help doctors decide when to stop antiviral treatment in people with flu or COVID-19. 86 adults took part, and researchers compared those whose treatment was guided by MxA levels to those receiving standard …

This study examined 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers looked at immune cells and virus levels in fluid from the lungs to understand why some people get so sick. The goal was to find better ways to treat severe flu and prevent lu…

This study tracked 289 healthcare workers in short-stay hospital wards to see how often they caught the flu, both with and without symptoms. Researchers wanted to understand the hidden spread of flu among staff, which can put vulnerable patients at risk. The findings may help enc…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study tested a community-designed program to increase COVID-19 and flu vaccination among underserved groups in East London, including minority ethnicities, migrants, and low-income individuals. About 5,900 adults from six GP practices were randomly assigned to receive the pr…

This study looked at how adults' immune systems respond to the live attenuated flu vaccine (nasal spray). The goal was to understand why this vaccine is less effective in adults than in children. By analyzing blood samples from 51 participants, researchers hope to design better f…

This study collected blood samples from 90 people—children aged 6 months to under 9 years and adults 65 and older—after they received the 2019-2020 flu vaccine. The samples were sent to health experts to analyze how well the vaccine worked, helping them decide which flu strains t…

This study followed 38 adults who survived severe H1N1 flu that caused lung failure. Researchers compared those who needed a machine to add oxygen to their blood with those who did not. They measured lung function, quality of life, and mental health at least 9 months after leavin…

This study gave 11 healthy adults a specially made H3N2 flu virus to see how their immune systems react. Participants stayed in a clinic so researchers could closely monitor symptoms and virus spread. The goal was to learn more about flu infection, not to test a treatment or vacc…

This study looked at how bacteria living in children's noses and guts interact with a nasal flu vaccine. About 200 kids aged 6 to 17 received the vaccine at different times, and researchers measured their immune responses and bacterial changes. The goal was to understand, not to …

This study looked at over 230,000 adults treated for lower respiratory tract infections (like pneumonia or bronchitis) in French primary care from 2015 to 2024. Researchers used anonymous electronic health records to describe patient characteristics and track antibiotic prescribi…

This study gave a nasal flu vaccine to 33 healthy adults to mimic a mild flu infection. Researchers then collected nose samples to measure how the virus grows and how the immune system reacts. The goal was to create a safe way to study flu infections in people, not to test a new …

This study looked for a substance in the blood (called HLA-G5) that might help doctors predict which flu patients in the intensive care unit (ICU) are at higher risk of severe breathing problems or death. Researchers studied 227 adults and children with severe flu. They also coll…

This study looked at 32 adults in the ICU on ECMO (a heart-lung machine) who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole moved through their bodies to find the best dose. The …