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Flu vaccine showdown: do Egg-Free shots work better?

NCT ID NCT03598439

Vaccine Sponsor: Marshfield Clinic Research Foundation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared how well egg-based and non-egg-based flu vaccines trigger the immune system in adults aged 18 to 64. Researchers wanted to see if egg adaptation weakens the vaccine's effectiveness. Over two flu seasons, 366 participants received one of three vaccines: a standard egg-based shot, a cell-culture shot, or a recombinant shot. The main goal was to measure antibody levels against a lab-grown flu virus.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Influenza vaccines (Flulaval Quadrivalent, FluBlok Quadrivalent, Flucelvax Quadrivalent)
What this could lead to
If successful, this could show that non-egg-based flu vaccines produce stronger immune responses, potentially leading to better flu protection.
What could go wrong
This is a completed Phase 4 trial with 366 participants, so results are limited to immune response measurements and may not directly translate to real-world effectiveness or apply to all age groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

366 people

The number who actually took part.

Started

Jul 2018

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-64 years * Marshfield Clinic patients living in or around Marshfield, Wisconsin since July 2015 * Willing and able to give informed consent and comply with study requirements Exclusion Criteria: * Receipt of 2018-19 influenza vaccine prior to study enrollment * Known to be pregnant at the time of enrollment * Current participation or plans to participate in another clinical trial involving an experimental agent * Presence of a contraindication to influenza vaccination * Plans to relocate outside the geographic location in the next two years

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Influenza

Contacts and locations

Locations

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin, 54449, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.