Drug could offer alternative to liver transplant for rare bleeding disorder

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * General criteria: * Age ≥ 18 years and \< 70 years * Subjects must have given their free and enlightened consent and have signed the consent form. * HHT related criteria * Patients monitored for clinically confirmed HHT disease. * Patients with severe liver involvement in relationship with the HHT disease * Patients with a high cardiac output on ultrasound. * Associated disease related criteria * Blood: neutrophil ≥ 1.0x109 / L and platelets ≥ 100x109 / L. * INR (International Normalized Ratio) ≤ 1.5 (except for patients on anticoagulants) and TCA ≤ 1.5 x upper limit of the standard laboratory * Renal function: creatinine ≤ 1.25 x upper limit of the standard laboratory. Patients who proteinuria to strip ≥ 2 + will have control of the Proteinuria of 24 hours to be ≤ 1g / 24 hours Exclusion Criteria: * • General criteria * Women who are pregnant or liable to become pregnant in the course of the trial. * Patients who have reached their majority but who are protected by the terms of the law (French public health code). * Refusal to give enlightened consent. * Patients who are not affiliated to a health insurance regime • Criteria for the medical history * Patients in whom the diagnosis of HHT disease has not been confirmed. * The presence of atrial fibrillation on the electrocardiogram at the inclusion. * The presence of cerebral arteriovenous malformations on the angioMRI done in the year prior to inclusion. * Existence of diverticulitis of the colon or sigmoid * Thrombosis within 6 months before inclusion * Infectious disease treated by antibiotics and unresolved at inclusion. * Patients with blood pressure that is not being controlled at the time of inclusion (systolic blood pressure\> 150 mmHg and / or diastolic\> 100 mmHg) with or without treatment. Patients who have high blood pressure can be included when the blood pressure numbers have been standardized by appropriate medical treatment. • Surgical criteria * Major surgery (including open biopsy) or severe trauma within 28 days preceding the start of treatment. • Medical treatments * Current or recent use of non steroidal anti-inflammatory drugs or antiplatelet therapy 10 days before the first administration of Bevacizumab. * Use of oral or parenteral anticoagulants or thrombolytic agents within 28 days preceding inclusion (anticoagulants given prophylactically are permitted). * Participation in another clinical trial within 28 days preceding inclusion. * Vaccination with live vaccines or against yellow fever during the treatment period. * Administration of phenytoin (Di-hydan ® DILANTIN ®) during the treatment period. • Allergy * Hypersensitivity to the active substance or any of its excipients. * Hypersensitivity to products made from Chinese hamster ovary (CHO) cells or to any other human or humanized recombinant antibodies.