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Tiny skin tests reveal psoriasis nerve clues

NCT ID NCT02652065

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how skin blood flow and nerve sensitivity differ in psoriasis plaques compared to healthy skin. Twenty adults with psoriasis on their back received mild electrical currents to deliver vasodilators (acetylcholine, sodium nitroprussiate, or plain water) into both plaque and healthy skin. Blood flow was tracked with laser Doppler, and nerve sensitivity was tested with fine filaments. The goal was to understand the link between nerve function and skin inflammation in psoriasis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acetylcholine, sodium nitroprussiate, and purified water delivered via iontophoresis
What this could lead to
If successful, this could help explain why psoriasis causes pain or discomfort, potentially guiding future treatments that target nerve-related inflammation.
What could go wrong
This is a very small, early-stage observational study (20 people) that measures only temporary skin responses, not a treatment. Results may not lead to any new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Feb 2016

Finished

Jul 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Type I psoriasis * Psoriasis plaques on the patient's back Exclusion Criteria: * BMI \> 25 * Diabetic patient * Arteriovenous disease history * Ongoing anti-inflammatory treatment * Major cardiovascular history (\<3 months) * Hypertension * Topical treatment on the back skin (\<7 days) * Systemic treatment (steroids, methotrexate, retinoids, cyclosporine) or phototherapy (\<1 month) * Pregnant women * Subject within exclusion period following a previous or ongoing biomedical study

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Psoriasis

Contacts and locations

Locations

  • Hôpital Edouard Herriot - Service de Dermatologie et Vénéréologie

    Lyon, 69437, France

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