PSORIASIS

This study follows 350 adults in France with moderate-to-severe plaque psoriasis who are starting a new medication called deucravacitinib. Researchers will track how well the drug controls skin symptoms and improves quality of life over time in everyday medical practice. The goal…

This study looks at whether people with psoriasis who are doing very well on the drug guselkumab (Tremfya) can safely wait longer between injections. Researchers will follow 100 adults whose doctors have already extended their dosing intervals beyond the standard 9 weeks. The goa…

This study watches 200 adults with moderate to severe psoriasis who switch from ustekinumab to guselkumab in everyday medical practice. Researchers track how well the new drug clears skin and check for side effects over 52 weeks. The goal is to see if switching helps patients ach…

This study tests a new biosimilar drug called CKD-704, which is similar to the approved psoriasis treatment Skyrizi. It involves 213 healthy adults who will receive a single dose of either CKD-704, EU-approved Skyrizi, or US-licensed Skyrizi. The goal is to compare how the drugs …

This study compares two ways of choosing biologic drugs for people with psoriasis or psoriatic arthritis: one based on a pre-screening strategy and the other on standard care. About 50 adults aged 18-75 are participating across multiple hospitals in Taiwan. Researchers will track…

This study compares high-dose and extended-interval guselkumab against the standard dose in 400 Chinese adults with moderate to severe plaque psoriasis. The goal is to see which dosing schedule works best to clear skin and stay safe over 86 weeks. Participants must have had psori…

This study tests a new drug called picankibart in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. The goal is to see if it can safely reduce skin plaques by at least 75% within 16 weeks. Participants will receive either the drug or a placebo, and their skin impr…

This study tests whether the drug bimekizumab, given early after a psoriasis diagnosis, can prevent the disease from becoming a long-term condition. Forty adults with mild plaque psoriasis for less than 6 months or more than 2 years will receive either bimekizumab injections or a…

This study compares two oral medications, methotrexate and tofacitinib, to see which works better for chronic plaque psoriasis. It involves 75 adults aged 18-70 with moderate to severe psoriasis that hasn't responded well to topical treatments. The main goal is to measure how man…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab therapy helps adults with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 participants will receive both treatments for up to 12 months. The main goals are t…

This study tests whether a probiotic called Lactobacillus plantarum can help treat psoriasis by restoring the natural balance of bacteria on the skin. About 184 adults with mild-to-moderate psoriasis will receive either the probiotic or a placebo for several weeks. Researchers wi…

This study follows 200 Italian adults with moderate to severe psoriasis who are already taking the oral medication deucravacitinib. Researchers will track how well the drug controls skin symptoms, its safety, and how it affects quality of life over time. The goal is to see how th…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. About 176 adults with psoriasis will receive either guselkumab or standard care. Researchers will use ultrasound to check for early joint changes and track …

This study tests a new skin barrier cream against plain petrolatum (Vaseline) in 26 adults with mild skin conditions like eczema, psoriasis, or dry skin. Participants apply the cream twice daily for 28 days. Researchers measure skin hydration, redness, and itch to see if the new …

This study looks at whether removing wheat from the diet can reduce skin inflammation and gut discomfort in people with mild-to-moderate psoriasis. Researchers will compare a wheat-free diet to a regular diet in 82 adults over several weeks. Participants will also undergo a wheat…

This study looks at whether adding treadmill walking to a restricted diet can improve symptoms in women who have both psoriasis and polycystic ovary syndrome (PCOS). Researchers will measure changes in psoriasis severity, body weight, waist size, and hormone levels. The study aim…

This study looks at whether adding an antidepressant (escitalopram) to standard psoriasis medication (methotrexate) works better than methotrexate alone for people who have both psoriasis and depression or anxiety. About 40 adults with moderate-to-severe psoriasis and mood issues…

This study tests whether a daily magnolia supplement called Viv can reduce immune-related proteins in the blood of adults with psoriasis. One hundred participants will take either Viv or a placebo for three months and provide blood samples at home. Researchers will measure change…

This study is testing a new laser (PALLAS) to treat skin diseases like vitiligo, psoriasis, alopecia areata, and atopic dermatitis. About 50 adults will receive UVB laser treatments twice a week for up to 3 months. The goal is to see if the laser improves the skin condition and i…

This study aims to find gene markers that can predict how well a person with psoriasis will respond to certain FDA-approved drugs. By analyzing blood and skin samples before and after treatment, researchers hope to create a personalized approach, saving patients from trying multi…

This study tests whether a 6-week balanced diet can lower inflammation in people with psoriasis, using a new total-body PET scanner. Five adults with psoriasis and a typical Western diet will get scans before and after the diet change. The goal is to see if the diet reduces skin …

This study aims to better understand the inflammatory genes involved in psoriasis, a chronic skin condition. Researchers will analyze genes like TNF-alpha and IL-6 in 13 adults with psoriasis. The goal is to find better ways to measure and manage the disease, not to test a new tr…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease). The tool helps patients understand immune checkpoint inhibitor drugs and their possible side effects. Researchers wil…

This study looks at how the drug Hemay005 is processed in the body by people with mild or moderate liver problems compared to those with healthy livers. It involves 24 adults with psoriasis. The goal is to find safe and effective doses for patients with liver impairment.

This study is looking at whether people with psoriasis have a higher risk of heart disease. Researchers will follow 1,000 adults with psoriasis, using heart scans and blood tests to find early warning signs. The goal is to better understand the link between psoriasis and heart pr…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study examines whether biologic drugs for psoriasis (targeting TNF-α, IL-17, or IL-23) increase the chance of developing or recurring genital warts. Researchers will review past medical records and follow 600 adults with moderate-to-severe psoriasis for 24 months. They will …

This study looks at how well people with psoriasis respond when they need three or more biologic treatments in a row. Researchers will use existing medical records from NHS hospitals in England to track responses from the 1st to the 10th biologic. The goal is to understand if peo…

This study aims to understand how the immune system and skin healing are connected. Researchers will study people with primary immune deficiency, eczema, or psoriasis, as well as healthy volunteers. Participants will provide blood and skin samples to help identify differences in …