PSORIASIS

This study tests an experimental oral drug called HSK44459 for adults with moderate to severe plaque psoriasis. About 150 participants will receive either the drug or a placebo to see if it can reduce skin symptoms by at least 75% after 16 weeks. The goal is to find a new treatme…

This study tests the drug apremilast in 425 adults with moderate-to-severe psoriasis that has lasted at least 6 months. The main goal is to see how many people achieve at least a 75% improvement in skin symptoms after 16 weeks. The study is open-label, meaning everyone knows they…

This phase 2 study tests an experimental drug called RAP-103 in 90 adults aged 18 to 70 with moderate-to-severe plaque psoriasis. Participants take either a 400 mg pill once daily, 200 mg twice daily, or a placebo for 8 weeks. The goal is to see if the drug improves skin clearanc…

This study tests whether adding metformin (a diabetes drug) to secukinumab (a standard psoriasis medication) works better than secukinumab alone for controlling moderate-to-severe plaque psoriasis in overweight or obese Chinese adults. About 186 participants will receive either t…

This study follows 200 adults with moderate-to-severe plaque psoriasis who have never taken biologic drugs before. Researchers will track how long participants continue taking guselkumab over two years and measure how well their skin clears up. The goal is to understand real-worl…

This study tests an experimental drug called D-2570 in 75 adults with moderate to severe plaque psoriasis. Participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug can clear at least 90% of skin symptoms. The study is not yet recrui…

This study will test two oral medications, methotrexate and apremilast, to see which one better reduces itching and improves quality of life in people with psoriasis. Eighty adults with psoriasis covering more than 8% of their body and related itching will take one of the drugs f…

This study tests a new cream made with tiny particles of apremilast for people with mild to moderate plaque psoriasis. About 36 adults will use either the new cream, a steroid cream, or both for 12 weeks. The goal is to see if the new cream reduces redness, thickness, and scaling…

This study looks at whether losing weight can make psoriasis treatments work better for overweight or obese people with moderate-to-severe plaque psoriasis. About 70 participants will either get standard psoriasis care alone or standard care plus a personalized weight loss plan (…

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how common related conditions like obesity, diabetes, heart disease, and psoriatic arthritis are. Researchers will also see which treatments patients are using and how severe their p…

This study tests a grain-of-rice-sized microdevice that places tiny amounts of approved drugs directly into patches of psoriasis or eczema. The goal is to see if the device can safely predict how a person's skin will respond to standard treatments. Ten adults with these skin cond…

This study looks at whether changing how much salt you eat can affect the amount of sodium in your skin and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet for 13 weeks and take either sodium tablets or placebo pills for 5 weeks each. Researchers wil…

This study explores whether detailed eye images can help predict and classify inflammatory skin conditions like psoriasis and eczema. Researchers will take high-resolution photos of the eyes of 950 people (patients and healthy volunteers) and use artificial intelligence to find p…

This study looks at why people with psoriasis may be more likely to develop gum disease. Researchers will measure immune markers and stress-related substances in saliva and gum fluid from 60 adults with psoriasis. They will also check gum health and ask about appearance-related a…

This study looks at whether short, AI-generated videos from a virtual doctor can help people with psoriasis use their topical medication more consistently. Fifteen adults with psoriasis will be split into three groups: one gets weekly AI videos, another gets weekly video calls wi…

This study tests whether letting patients report their symptoms online can help schedule follow-up visits more flexibly. About 250 adults with chronic skin conditions like eczema or psoriasis will be assigned to either standard fixed appointments or a system that adjusts visits b…

This study aims to develop and test an AI system that uses smartphone photos with a color card to measure redness in psoriasis lesions. Currently, doctors assess redness by eye, which can vary. The goal is to see if this smartphone method is as accurate as a standard, expensive c…

This study will follow 50 people in Costa Rica who are already taking IL-23 inhibitors (guselkumab or risankizumab) for psoriasis or psoriatic arthritis. Researchers will track how well the drugs improve skin and joint symptoms and quality of life, and note any side effects. The …

This study will look at existing medical records from 20,000 people aged 12 and older in Italy who have psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to learn about the types of treatments patients receive, how their diseas…

This study aims to create a standard method for collecting and analyzing skin oil (sebum) to find biomarkers for skin diseases like acne, eczema, and psoriasis. Researchers will study 200 participants, including healthy people and those with skin conditions, to see how skin oil c…