Eye scans could reveal hidden skin disease risk
NCT ID NCT07434076
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will take high-resolution photos of the eyes of 950 people with psoriasis, eczema, or hives, plus healthy volunteers. Using artificial intelligence, researchers aim to find eye patterns linked to these skin conditions. The goal is to create a noninvasive tool for earlier diagnosis and to predict related health risks like metabolic problems.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 950 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
As an exploratory cross-sectional study involving high-dimensional image-omics modeling, we plan to enlarge the sample size. We intend to recruit 200 cases each of psoriasis, atopic dermatitis, and urticaria, and 150 healthy controls. The dataset will be split into training and internal validation sets at an 8:2 ratio. An external independent validation cohort of 200 subjects is planned. The total sample size is therefore approximately 950 participants.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: For patients with inflammatory skin disease: Clinical diagnosis of one of the three target inflammatory skin diseases (psoriasis, atopic dermatitis, or urticaria). Age ≥ 18 and ≤ 65 years, any sex. Understands and signs informed consent. For healthy controls: Do not meet diagnostic criteria for any of the three inflammatory skin diseases above. Age ≥ 18 and ≤ 65 years, any sex. Understands and signs informed consent. Exclusion Criteria: For patients with inflammatory skin disease: Exclude any subject meeting any of the following: Refusal to undergo examinations. Presence of acute/active infectious ocular disease (e.g., viral keratoconjunctivitis). Corneal perforation or high-risk perforation where contact procedures cause severe photophobia, eye pain, inability to keep eyes open or fixate. Nystagmus or other conditions that prevent fixation. Pupillary non-dilation (e.g., posterior synechiae) that precludes fundus imaging. Severe eyelid lesions (e.g., marked swelling, ectropion, entropion) that prevent globe exposure. Participation in other clinical trials within the previous 3 months or concurrent participation in other interventional studies. * Healthy control - exclusion criteria Exclude any subject meeting any of the following: Presence of other skin diseases that could affect study assessments (e.g., atopic dermatitis, urticaria, scabies). Refusal to undergo examinations. Acute/active infectious ocular disease (e.g., viral keratoconjunctivitis). Corneal perforation or high-risk perforation that causes severe photophobia, eye pain, inability to keep eyes open or fixate during contact procedures. Nystagmus or other reasons preventing fixation. Pupillary non-dilation (e.g., posterior synechiae) that prevents fundus imaging. Participation in other clinical studies within the previous 3 months or currently participating in other clinical trials.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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