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Psoriasis relief on a plate? diet trial tests wheat and dairy elimination

NCT ID NCT05644782

Symptom relief Sponsor: University of Palermo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether removing wheat and cow's milk from the diet can reduce inflammation and improve skin symptoms in people with mild-to-moderate psoriasis. 82 participants will follow either a wheat- and dairy-free diet or a control diet for 2 months, then some will be re-exposed to wheat to see if symptoms return. The goal is to understand the link between diet, gut health, and psoriasis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
wheat- and dairy-free diet
What this could lead to
If it works, this could point toward a simple dietary change to help manage psoriasis symptoms.
What could go wrong
This is a small, early-stage trial with no blinding, so results may be influenced by placebo effects. The diet is restrictive and may be hard to follow long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 82 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria of psoriasis patients * age \>18 and \<65 years; * no systemic therapy for psoriasis for at least 3 months before inclusion in the study; * negativity of anti-deamidated gliadin protein (anti-DGP) immunoglobulins (Ig) class A (IgA) and immunoglobulins (Ig)G, anti-tissue transglutaminase (anti-tTG) class IgA and IgG, and Endomysium antibodies (EmA); * absence of WA (negative prick-test and/or specific serum immunoglobulins (Ig)E assay for wheat, gluten, and gliadin). Exclusion criteria of psoriasis patients age \<18 and \>65 years; * severe chronic plaque-type psoriasis (based on BSA); * self-exclusion of gluten/wheat from the diet and refusal to reintroduce it, for diagnostic purposes, before entering the study; * pregnancy; * alcohol and/or drug abuse; * Helicobacter pylori and other bacterial and/or parasitic infections; * diagnosis of chronic inflammatory bowel disease and other organic pathology affecting the digestive system (e.g., severe liver disease), nervous system diseases, major psychiatric disorders, immunological deficits, and impairments that limit physical activity; * diagnosis of cancer * treatment with steroids and/or immunological therapies; * patients undergoing chemotherapy and/or radiotherapy.

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Conditions

The condition(s) this trial relates to.

celiac disease psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gluten sensitivity Psoriasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dermatology Department of the University Hospital 'P. Giaccone' of Palermo, Italy,

    RECRUITING

    Palermo, Palermo, 90127, Italy

  • Internal Medicine Department of the University Hospital of Palermo

    RECRUITING

    Palermo, Palermo, 90127, Italy

  • Internal Medicine Division of the "Cervello-Villa Sofia" Hospital

    RECRUITING

    Palermo, PA, 90146, Italy

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