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Shingrix vaccine under the microscope: can it shield patients on Immune-Weakening drugs?

NCT ID NCT07534007

Knowledge-focused Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the Shingrix vaccine (for shingles) works in people with psoriasis or myelofibrosis who are taking drugs that weaken their immune system. Researchers will compare their immune response to that of similar patients not on these drugs. The goal is to understand if the vaccine still provides strong protection in these vulnerable groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All the subjects will be enrolled after signature of informed consent. Follow-up will be performed in case of confirmed arbovirus infection.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Patients over 18 years of age; * All genders are eligible for the study; * Patients with psoriasis receiving immunomodulant therapy (anti-TNF); * Patients with psoriasis who do not require immunomodulant therapy; * Patients with myelofibrosis receiving immunomodulant therapy (anti-JAK, such as Ruxolitinib); * Patients with myelofibrosis not receiving immunomodulant treatment; * Life expectancy (as estimated by the treating physician) ≥ 12 months or more; * Signed informed consent. Exclusion Criteria: * • At the end of the observation period; * In case of death; * If informed consent is revoked.

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Conditions

The condition(s) this trial relates to.

myelofibrosis primary myelofibrosis psoriasis herpes zoster prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RZV vaccine (shingrix ®)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fondazione IRCCS Policlinico San Matteo di Pavia

    RECRUITING

    Pavia, Lombarda, 27100, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.