Fondazione Irccs Policlinico San Matteo Di Pavia

This study is testing whether a dietary supplement called Euglycem, when added to a recommended diet, can help lower blood sugar levels in people with prediabetes (dysglycemia). It will compare the supplement plus diet to diet alone over three months. The goal is to see if this a…

This study is checking how well the newer shingles vaccine works in people with weakened immune systems, such as those with cancer, arthritis, or blood disorders. Researchers will measure the body's immune response and track side effects and shingles cases after vaccination. The …

This study tests whether bringing advanced heart-lung machines directly to cardiac arrest scenes can save more lives. Researchers in Pavia, Italy, will send specialized teams to 20 patients who aren't responding to standard CPR. The goal is to see if starting this high-tech treat…

This study is testing a special breathing technique to protect the heart during radiation treatment for breast cancer. It involves holding a deep breath while radiation is delivered, which moves the heart slightly away from the treatment area. Researchers are observing 400 patien…

This study aims to improve a type of immunotherapy called adoptive cell therapy for children with solid tumors. Researchers are growing special immune cells (cytotoxic T lymphocytes) in bioreactors and testing their ability to recognize and kill pediatric cancer cells in the lab.…

This study aims to see which of two food supplements, Cynacol or Metacol, is better at lowering 'bad' cholesterol (LDL-C) over 90 days. It will involve 40 adults with mildly high cholesterol who are not on other cholesterol medications. Researchers will compare changes in cholest…

This study is collecting real-world information on how well a new combination of immunotherapy drugs (nivolumab and ipilimumab) plus a short course of chemotherapy works for people with advanced non-small cell lung cancer that has spread. It will follow 300 patients across Italy …

This study is testing two non-invasive scanning methods to see if they can predict which premature babies will develop a serious, chronic lung condition called bronchopulmonary dysplasia (BPD). Researchers will enroll 104 very small, premature infants in Italy and use special che…

This study aims to help emergency room doctors better identify when dizziness or vertigo is caused by a serious neurological problem like a stroke, rather than a minor inner ear issue. Researchers will test a simple bedside examination method on 825 adult patients coming to the E…

This study aims to help doctors better distinguish between two rare and similar blood disorders: EGPA and HES. Researchers will collect health data from 60 patients with either condition and use artificial intelligence to find patterns that separate them. The goal is to create a …

This study aims to see if a modern lab technique called PCR can improve how doctors diagnose serious parasitic infections like malaria and leishmaniasis. Researchers will compare the new PCR method against older microscope-based tests using about 200-300 stored patient samples. T…

This study is creating a detailed registry of patients with serious brain and spinal cord infections, like meningitis and encephalitis. It will track 520 patients admitted to a single hospital to collect information on their symptoms, treatments, and recovery. The main goal is to…

This study aims to find out if patients recover just as well in a regular hospital ward as they do in an Intensive Care Unit (ICU) after major reconstructive surgery for head and neck cancer. Researchers will compare complication rates and hospital stay length for 192 patients se…

This study is creating a long-term registry of 1500 lung cancer patients treated at a major Italian hospital. It will track patients from 2019 to 2035 to understand how different treatments work in real-world practice, how long patients live, and how the disease progresses over t…

This study aims to better understand how damaged lungs behave in patients who are on breathing machines for severe respiratory failure. Researchers will observe 100 patients, analyzing data from the ventilator and other tests to measure 'lung instability'—how much lung tissue ope…

This study aims to understand how autoimmune atrophic gastritis (AAG) progresses over time in 600 adults already diagnosed with the condition. Researchers will track patients to learn how often serious complications like stomach cancer develop and identify which factors increase …

This study aims to understand how two common surgeries for uterine fibroids affect pelvic floor symptoms and measurements. Researchers will follow 200 women who are scheduled for either a hysterectomy (removing the uterus) or a myomectomy (removing just the fibroids). They will c…

This study aims to understand the differences in oxidative stress—a type of chemical imbalance in the body—between adults with Type 1 diabetes and a similar form called LADA. Researchers will recruit 150 adult patients to provide blood samples during a single visit, analyzing var…

This study aims to better understand the physical strength and elasticity of the aortic wall in people with aortic aneurysms or dissections. Researchers will collect and test small tissue samples from 250 patients undergoing heart surgery, comparing those with aortic disease to t…

This study aims to understand how common and severe enterovirus infections are in newborns in Italy, with a focus on a specific strain called Echovirus 11. Researchers will collect and analyze samples from 1,600 babies admitted to neonatal intensive care units to learn more about…

This study aims to better understand how older women with breast cancer respond to a specific class of drugs called CDK4/6 inhibitors. Researchers will observe 100 patients in real-world settings to compare side effects, treatment changes, and survival outcomes between women aged…

This study aims to collect information on how well joint replacement surgeries work for adults with rare, inherited bleeding disorders like hemophilia. Researchers will look back at past patient records and follow new patients to understand how often surgeries need to be repeated…

This study aims to understand why some children need a second adenoid removal surgery. Researchers will follow 1,200 children to see if factors like their age, size, or throat anatomy affect how completely the adenoid tissue is removed during the first surgery. The goal is to gat…

This study aims to understand the genetic causes of familial pulmonary fibrosis, a form of lung scarring that runs in families. Researchers will analyze DNA from 126 participants, including affected family members and unrelated individuals with the disease for comparison. The goa…

This study aims to better understand how a common virus called parvovirus B19 affects pregnant women and their babies. Researchers will observe 150 pregnant women who have the infection to learn how often it passes to the fetus and what complications can occur. The goal is to gat…

This study aims to develop a better way to collect stem cells from donated umbilical cord blood. Researchers will compare a new, gentler liquid-based method to the standard technique, and also test if a mild ozone treatment helps the cells grow and survive freezing. The study inv…

This study aims to understand how blood test patterns differ between patients whose inactive liver cysts were treated with medication and those whose cysts became inactive on their own. Researchers will enroll 100 adults with these specific parasitic cysts in the liver. The goal …

This study aims to understand how a common mold called Aspergillus spreads in hospital wards and infects patients with weakened immune systems. Researchers will test the air and take nose swabs from about 200 adults admitted to a hematology ward to see if mold levels in the envir…

This study aims to understand why a common virus (HCMV) sometimes passes from a pregnant woman to her unborn baby, which can cause serious health problems. Researchers will study the immune systems of 90 pregnant women who recently got the virus to find specific signs in their bl…

This study is creating a registry to track the long-term health of people with chronic heart failure. Researchers will follow 101 patients for up to 10 years to understand how the disease progresses over time. The main goal is to collect detailed information to see how patients f…

This study aims to understand why certain blood cancers sometimes run in families. Researchers will analyze the genes of patients who developed these cancers at a young age or have family members with similar conditions. The goal is to identify inherited genetic factors that may …

This study aims to understand why some advanced liver cancer patients respond well to immunotherapy while others don't. Researchers will analyze blood samples from 20 patients before and during treatment to look for patterns in immune cells. The goal is to find biological markers…

This study aims to understand why a specific gene (IGLV1-44) causes two rare and serious blood disorders: AL amyloidosis and POEMS syndrome. Researchers will analyze blood and bone marrow samples from 100 patients to identify unique patterns in the gene. The goal is to improve ea…

This study aims to see if advanced MRI scans can detect areas of low oxygen in the lungs of people with early-stage idiopathic pulmonary fibrosis (IPF), a serious scarring disease. Researchers will scan 50 participants to see if these oxygen maps can identify patients who might b…

This study aims to develop a personalized immune score to predict which immunocompromised patients (like transplant recipients) are at highest risk for severe infections. Researchers will measure various immune cells and responses in 150 patients before or shortly after their tra…

This study aims to understand how the immune systems of 500 adults in Italy respond to infections from viruses spread by mosquitoes and ticks, like West Nile and Dengue. Researchers will use a special lab test to measure a specific part of the immune defense. The goal is to gathe…

This study aims to understand why some leukemia patients in remission experience severe side effects from a common maintenance drug combination. Researchers will measure drug levels in the blood of 14 patients to see if higher levels are linked to more severe low blood counts. Th…

This study aims to test an Italian version of a checklist (the Braden QD Scale) designed to predict which hospitalized newborns are most at risk for developing painful pressure sores. Researchers will observe 600 infants in a neonatal intensive care unit to see if the tool works …

This study is trying to find out if a simple blood test for a protein called BNP, taken when a baby is just one month old, can help predict which teenagers are at risk for developing metabolic syndrome. Metabolic syndrome is a group of conditions like high blood pressure and high…

This study aims to understand how a specific sugar modification on certain proteins might cause AL amyloidosis, a serious disease where proteins clump together and damage organs. Researchers will analyze blood and bone marrow samples from 100 people with related blood cell disord…

This study aims to understand how the immune system in the nose responds to respiratory viruses like COVID-19. Researchers will compare 40 immunocompromised patients (such as transplant recipients) with healthy volunteers. The goal is to learn how medical conditions and treatment…

This study is creating a detailed registry of 600 patients with primary cutaneous T-cell lymphoma (a type of skin cancer) treated at a specific clinic in Italy. The goal is to collect past and future patient information to better understand how common different forms of the disea…

This study is creating a long-term registry of patients with infective endocarditis, a serious heart infection. It aims to collect detailed information on patient characteristics and their disease journey over 20 years. The goal is to identify which factors are linked to worse he…