Fondazione Irccs Policlinico San Matteo Di Pavia

This study tests whether a heart-lung machine (ECMO) can be used outside the hospital to help people whose hearts have stopped and won't restart with standard CPR. Researchers will try to place the machine in 20 adults aged 18-70 who have a witnessed cardiac arrest and meet other…

This study compares two food supplements, Cynacol and Metacol, to see which is better at lowering LDL (bad) cholesterol in people with mild high cholesterol. Researchers will track cholesterol levels and side effects over 90 days in 40 adults aged 35-70. The goal is to find a saf…

This study is testing whether a supplement called Euglycem, when taken with a standard diet, can lower fasting blood sugar more than diet alone in people with dysglycemia (abnormal blood sugar levels). About 108 adults with a BMI of 30 or less will take Euglycem or just follow th…

This study looks at a non-surgical procedure called renal embolization to shrink enlarged kidneys in 30 dialysis patients with autosomal dominant polycystic kidney disease (ADPKD). The goal is to reduce kidney size enough to allow for a kidney transplant, which is often delayed w…

This study aims to see if a molecular test called PCR can diagnose malaria, leishmania, and pneumocystis faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve how these infections are detected and …

This study looks at how well the shingles vaccine works in 300 people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects after vaccination. The goal is to understand if the vaccine provi…

This study aims to develop a personalized immune score to predict severe infections in immunocompromised patients, such as those who have received stem cell or organ transplants. Researchers will measure immune cells and pathogen-specific responses before or one month after trans…

This study aims to understand how a specific sugar modification (N-glycosylation) on abnormal proteins contributes to AL amyloidosis, a rare disease where these proteins build up and damage organs. Researchers will analyze blood and bone marrow samples from 100 adults with relate…

This study looks at 100 patients with acute respiratory failure who are on a breathing machine (ventilator). The goal is to measure lung instability, which happens when parts of the lung open and close with each breath. By analyzing data from the ventilator, researchers hope to b…

This study looks at 100 adults with inactive liver cysts caused by a parasitic infection (echinococcosis). Researchers want to see if a blood test called immunoblotting shows different protein patterns between people who received treatment and those who did not. The goal is to be…

This study looks at how effective vaccines are in preventing serious infections in people who have received a bone marrow or solid organ transplant. Researchers will check the immune system's ability to respond to vaccines and track infections and deaths over five years. The goal…

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18-50. Researchers will analyze blood samples from 1,725 patients in Lombardy, Italy, and check their family members for inherited heart disease risks. The goal is to better understand these g…

This study is building a large online registry of 1,000 people with ATTR amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect information from diagnosis through follow-up to better understand how the disease progresses in real life. The…

This study measures oxidative stress (a type of cell damage) in 150 adults with either type 1 diabetes or LADA. Researchers will take blood samples once and, for newly diagnosed patients, again after 3 months of treatment. The goal is to see if stress markers differ between the t…

This study tests whether advanced MRI scans can detect low oxygen areas in the lungs of people with early-stage idiopathic pulmonary fibrosis (IPF), a rare scarring lung disease. Researchers will enroll 50 participants to see if MRI can identify patients whose disease might progr…

This study looks at how often people on dialysis develop high blood pressure in the lungs (pulmonary hypertension) and what factors contribute to it. Researchers will follow 70 adults on long-term dialysis for two years, using heart ultrasounds and other tests to track their cond…

This study aims to improve how stem cells are collected from donated umbilical cord blood. Researchers will compare a new, gentler method that uses a special liquid to separate cells without damaging them, versus the traditional spinning method. They will also test if treating th…

This study is creating a large registry of 9,000 adults with lymphoproliferative disorders (a type of blood cancer). Researchers will follow participants for up to 10 years to see how long they live, how different treatments work, and what factors affect their disease. The goal i…

This study looks at how the drug treosulfan is processed in children getting stem cell transplants. The goal is to find the right dose for each child to reduce side effects and improve outcomes. About 70 children with cancer or other blood disorders will participate. Researchers …

This study looks at how the Shingrix vaccine protects people with psoriasis or myelofibrosis who take drugs that affect the immune system. Researchers will compare the immune response in 150 patients who are either on or off these therapies. The goal is to understand if the vacci…

This study is creating a large European registry of 400 newly diagnosed AL amyloidosis patients. Researchers will collect blood and tissue samples to study the disease at a molecular level, aiming to improve diagnosis and predict outcomes. The goal is to better understand the dis…

This study is for adults with acute myeloid leukemia (AML) who are in remission after treatment with a combination of venetoclax and a hypomethylating agent. The goal is to see if the amount of venetoclax in the blood is linked to severe low white blood cell counts (neutropenia).…

This study aims to develop a new blood test that looks at how immune cells (T cells) react to viruses spread by mosquitoes and ticks. Researchers will recruit 500 adults in Italy with suspected infections to see if this test can help diagnose these viruses more accurately than cu…

This study aims to find immune markers that can predict whether a pregnant woman with a first-time HCMV infection will pass the virus to her unborn baby. Researchers will analyze blood samples from 90 pregnant women and newborns to see which immune responses are linked to lower t…

This study is testing whether a new Italian version of the Braden QDS scale can accurately predict the risk of pressure injuries (bedsores) in newborns admitted to the Neonatal Intensive Care Unit (NICU). Researchers will enroll 600 infants under 28 days old and weighing less tha…

This study aims to find the genetic causes of familial pulmonary fibrosis, a lung disease that runs in families and causes scarring that makes breathing hard. Researchers will analyze DNA from 126 adults who have at least one close relative with the disease. The goal is to identi…

This study will screen 760 people in Italy who have early blood conditions (MGUS or smoldering multiple myeloma) to find cases of AL amyloidosis sooner. Researchers will also test new diagnostic tools and track treatment responses. The goal is to improve diagnosis and care for th…

This study is creating a registry of 101 adults with chronic heart failure to collect detailed health information over time. Researchers will track how the disease progresses and measure survival rates at 1, 5, and 10 years after diagnosis. No new treatments or medications are be…

This study looks at how the immune system in the nose responds to respiratory viruses like COVID-19 in people with weakened immune systems compared to healthy volunteers. Researchers will collect samples from 40 adults aged 18 to 90 to measure immune cell activity. The goal is to…

This study looks at how a specific gene (IGLV1-44) causes two rare blood disorders: AL amyloidosis and POEMS syndrome. Researchers will analyze blood and bone marrow samples from 100 adults with these conditions or multiple myeloma. The goal is to find unique patterns in the gene…

This study looks at whether holding your breath during breast cancer radiation can lower the amount of radiation reaching the heart. Researchers will compare heart doses in 400 women who use a special breathing device versus those who breathe normally. The goal is to find a safer…

This study aims to better understand how enteroviruses, especially Echovirus 11, affect newborns in Italy. Researchers will analyze samples from 1,600 infants admitted to neonatal intensive care units to track the virus's spread, identify risk factors for severe illness, and impr…

This study creates a registry of 1500 lung cancer patients treated at one hospital. Researchers will collect data from 2019 to 2035 to learn about survival, how the disease changes over time, and how well different treatments work in real life. The goal is to improve future care …

This study is creating a registry of 600 people with primary cutaneous T-cell lymphoma, a rare type of skin cancer. Researchers will collect past and future medical data to understand how common different forms of the disease are and how long people live with each type. The goal …

This study is collecting information from 300 people in Italy with advanced non-small cell lung cancer who are receiving a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus chemotherapy as their first treatment. The goal is to see how well this treatment work…

This study looks at the strength of the aorta (the main artery) in people with aortic disease compared to those without. Researchers want to see if certain patient traits are linked to a weaker aortic wall, which could help predict rupture risk. About 250 adults having heart surg…

This study looks at whether a protein called BNP, measured in babies and again in adolescence, can help identify teens at risk for metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and diabetes. Researchers will follow 70 teens who were born either ful…

This study gathers information from 418 patients diagnosed with endocarditis, a serious heart infection. The goal is to better understand the disease and identify factors that lead to worse outcomes. No new treatments are being tested; instead, researchers will review medical rec…

This study looks at whether a quick bedside exam can help emergency room doctors tell the difference between harmless vertigo and serious causes like stroke. Researchers will study 825 adults who come to the ER with dizziness or unsteadiness. The goal is to improve diagnosis, red…

This study looks at how a common mold called Aspergillus spreads in hospital wards and affects blood cancer patients. Researchers will use nasal swabs and air samples to track the mold. The goal is to understand the link between mold in the environment and serious infections in v…

This study follows 600 adults with autoimmune atrophic gastritis, a condition where the immune system attacks the stomach lining, leading to nutrient deficiencies and increased cancer risk. Researchers aim to track how the disease progresses over time and identify factors that le…

This study looks at how parents of children with blood cancers or solid tumors cope with stress and how their coping style affects their child. Researchers will use questionnaires to understand the emotional resources and parent-child relationship. The goal is to create better ps…

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the baby and what complications may occur. Researchers will track problems like anemia, fluid buildup, and brain issues in the fetus or newborn. The goal is to better understan…

This study is building a large registry of 5000 people with AL amyloidosis, a rare disease where abnormal proteins damage organs. Researchers will collect information from medical records and follow-ups to see how the disease progresses and how current treatments affect it. No ne…

This study looks for inherited genetic changes that might make some people more likely to develop myeloproliferative neoplasms (MPN), a group of blood disorders. Researchers will study 313 young patients (diagnosed before age 27) or those with a family history of blood cancers. T…

This study looks at whether patients who have head and neck reconstructive surgery with a free flap (tissue moved from another body part) can recover just as well on a regular hospital ward as in the intensive care unit (ICU). The researchers will compare minor and major complica…

This study follows 200 women with symptomatic uterine fibroids who are scheduled for either hysterectomy or myomectomy. Researchers will compare how each surgery affects pelvic floor symptoms like urinary urgency and pain over 12 months. The goal is to understand which surgical a…

This study is creating a registry of 520 patients with central nervous system (CNS) infections, such as meningitis and encephalitis. Researchers will track outcomes like survival at discharge to better understand these rare but serious conditions. No new treatments are being test…

This study looks at blood samples from 20 adults with advanced liver cancer who are starting immunotherapy. Researchers want to see if certain genetic patterns in immune cells can predict whether the treatment will work. The goal is to find markers that help doctors choose the be…

This study looks at how well hip, knee, shoulder, and other joint replacement surgeries work in adults with inherited bleeding disorders like hemophilia. Researchers will collect information from medical records and follow patients over time to understand risks, complications, an…

This study looks at whether a special imaging technique (electrical impedance tomography) and lung ultrasound can help doctors predict which premature babies will develop a serious lung condition called bronchopulmonary dysplasia (BPD). The study will include 104 preterm infants …

This study looks at how older women (70+) with breast cancer handle CDK4/6 inhibitors, a common targeted therapy. Researchers will track side effects and compare them to younger patients. The goal is to provide better treatment guidance for this often-underrepresented group.

This study follows 200 adults with rheumatoid arthritis who are in stable remission on standard medications. Researchers will track their health over up to 5 years using exams, ultrasound, and X-rays to see who stays well and who has a flare. The goal is to better understand remi…

This study looks at how to grow special immune cells (called CTLs) that can recognize and kill pediatric solid tumors like neuroblastoma and osteosarcoma. Researchers are testing a new way to grow these cells in a device called a G-Rex bioreactor to make them stronger and last lo…

This study aims to understand why some children still have adenoid tissue after surgery, which can cause symptoms to return. Researchers will look at factors like age, sex, weight, and mouth anatomy in 1,200 children to see if these influence how completely the tissue is removed.…

This study is following 300 people with suspected or confirmed systemic vasculitis over 10 years. Researchers are collecting data on symptoms, imaging, and biomarkers to identify who is at higher risk for relapse or poor outcomes. The goal is to better understand the disease and …

This study collects medical information from 60 adults diagnosed with either EGPA or HES, two rare conditions that cause high levels of certain white blood cells. Researchers will use artificial intelligence to find patterns that help doctors tell the diseases apart and predict w…

This study tests whether advanced MRI scans can identify different immune environments inside lung tumors. Currently, this information requires a tissue biopsy. If successful, MRI could provide a non-invasive way to understand the tumor's immune status. The study will enroll 50 a…