Can a Heart-Lung machine in an ambulance save more cardiac arrest victims?
NCT ID NCT07155772
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether starting a heart-lung machine (ECMO) at the scene of a cardiac arrest, instead of waiting until arrival at the hospital, can improve survival and brain function. Researchers will enroll 20 adults aged 18-70 who suffer a cardiac arrest that does not respond to standard CPR. The goal is to see if this approach is feasible and reduces the time the heart and brain go without blood flow.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Extracorporeal CardioPulmonary Resuscitation (eCPR) - a machine that pumps and oxygenates blood outside the body
- What this could lead to
- If this works, it could show that starting ECMO before reaching the hospital saves more lives and reduces brain damage after cardiac arrest.
- What could go wrong
- This is a very small early feasibility study with only 20 people. The procedure is complex and risky, and success in this setting may not translate to broader use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Oct 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * out-of-hospital cardiac arrest occurred in Pavia province * the age of the patient is between 18 and 70 * witnessed cardiac arrest * CPR started within 5 minutes of the patient's collapse or presence of gasping at the arrival of the ACLS team * eCPR team arrived within 60 minutes of the patient's collapse * etCO2 ≥ 10 mmHg * mechanical chest compression is ongoing * refractory cardiac arrest after at least 15 minutes of ACLS Exclusion Criteria: * Modified Rankin Scale (mRS) ≥ 3 * Advanced COPD or other advanced pulmonary illness * End-stage or metastatic neoplasm
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fondazione IRCCS Policlinico San Matteo
RECRUITINGPavia, Pavia, 27100, Italy