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Could an antidepressant boost psoriasis treatment?

NCT ID NCT07432815

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
methotrexate and escitalopram
What this could lead to
If it works, this could point toward a better treatment approach for people with both psoriasis and depression or anxiety.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. The combination therapy may not work better than methotrexate alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged \>18 and \<60 years * Moderate to severe psoriasis (PASI ≥10 or BSA ≥10%) * Moderate to severe depression (BDI ≥20 or HAM-D ≥17) and/or moderate to severe anxiety (BAI ≥16 or HAM-A ≥25) Exclusion Criteria: * Current substance abuse * Systemic psoriasis treatment within the past 3 months * Pregnancy or breastfeeding * Hypersensitivity to methotrexate or escitalopram * Erythrodermic or pustular psoriasis * Contraindications to methotrexate (e.g., hepatic disease or malignancy)

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression depressive disorder psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Depression Psoriasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kasralainy

    RECRUITING

    Cairo, Cairo Governorate, 11562, Egypt

    Contact Email: •••••@•••••

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