Kidney drug may work through gut bacteria, study hints

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 80 years old * Non-diabetic patient * PChronic renal failure patient with a medical indication for the introduction of dapagliflozin as part of routine care: o either according to the marketing authorization, namely: * A GFR estimated between 25 and 60 mL/min/1.73m2 according to the CKD EPI formula. * A urinary albumin/creatinine ratio \> 200mg/g and \< 5000 mg/g * Be treated with the maximum tolerated dose of renin-angiotensin system inhibitors for at least 4 weeks. o or according to the nephrologist's assessment if the patient has other indications such as chronic heart failure according to the marketing authorization or any patient with a GFR \> 20 ml/min according to the KDIGO recommendations for the management of CKD * BMI between 18 and 30 kg/m2 * Patient not taking dapagliflozin (or any other treatment containing iSGLT2 or iSGLT1) * Very regular bowel movements between 24 and 48 hours * Patient following the dietary recommendations recommended during CKD (a sodium intake targeting 6g NaCl/day +/-20% and a protein intake of 0.6g/kg/d +/-20%) * Affiliation to social security Exclusion Criteria: * Taking drugs can interfere with the intestinal microbiota (prebiotics, probiotics, postbiotics, antibiotics) in the last 6 weeks * Patient using high dose laxatives (more than 2 per day, for more than 3 months) * Patient with a foreseeable transplant or dialysis project within the next 6 months. * Patient with a colectomy, a resection of the small intestine or a cholecystectomy * Patient with a progressive and unstabilized inflammatory, infectious, cardiovascular or neoplastic disease * Inability to understand the nature, follow-up and possible consequences of the study. * Patient in exclusion period from previous study or already participating in a clinical research protocol having an impact on the endpoints of the study * Patient under guardianship or in safeguard of justice * Pregnant, parturient or breastfeeding women