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Could a common numbing drug replace opioids after cancer surgery?

NCT ID NCT02894710

Symptom relief Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving the numbing drug lidocaine through a vein during and after ear, nose, and throat cancer surgery could lower the need for strong opioid painkillers and reduce long-term pain. 143 adults having major head and neck cancer surgery were randomly assigned to receive either lidocaine or a placebo. Researchers measured how much morphine patients needed in the first two days after surgery and checked for chronic pain 3 to 6 months later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

143 people

The number who actually took part.

Started

Dec 2016

Finished

Dec 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient undergoing major carcinological ENT surgery (total laryngectomy, oropharyngectomy with or without mandibulotomy, crico-hyoido-epiglotto-pexy, intraoral extended resection, partial laryngectomy, partial pharyngectomy, extended pelvectomy, pelviglossectomy, with or without pectoralis major flap or free flap, with or without lymphadenectomy) * Patient receiving standardized Patient Controlled Analgesia (PCA) * Written informed consent Exclusion Criteria: * Hypersensitivity to local anesthetics of the amide group, * Acute porphyria * Atrioventricular conduction disorders requiring permanent electro-systolic * Epilepsy not controlled by treatment * Hepatocellular insufficiency (PT\<50%) or cirrhosis * Systolic heart failure (LVEF \<50%) * Major inflation State * Hypersensitivity to any component of Glucose 5% * Treatment with beta-blockers or antiarrhythmic of Vaughan Williams classification * BMI \> 30kg/m2 * Patient already treated for chronic pain with level 3 analgesic or for neuropathic pain * Pregnant or lactating women * Refusal to give consent * Patient under legal protection measure

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Conditions

The condition(s) this trial relates to.

head and neck cancer Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carcinologic ear, nose, and throat (ENT) surgery

Contacts and locations

Locations

  • Centre Léon Bérard

    Lyon, 69008, France

  • Hospices Civils de Lyon / Hôpital de la Croix Rousse

    Lyon, 69004, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.