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Scientists hunt for genetic clues in rare lung syndrome

NCT ID NCT02439528

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healthy individuals. The goal was to find genetic differences that might explain why some people get this severe disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

250 people

The number who actually took part.

Started

Mar 2015

Finished

Dec 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 80 years old. * Patient with Idiopathic Pulmonary Fibrosis Or * Patient with emphysema Or * Patient with combined pulmonary fibrosis and emphysema syndrome Or * Patient reporting no chronic lung disease Exclusion Criteria: * Other causes of interstitial lung disease or context: * Connective * Pneumonia drug * Pneumoconiosis * Sarcoidosis * histiocytosis, lymphangioleiomyomatosis, etc. * Refusal to participate in the study or to sign the consent * Inability to give informed about the information * Woman breastfeeding or pregnant * No coverage for Social Security * Deprivation of Civil Rights

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Conditions

The condition(s) this trial relates to.

combined pulmonary fibrosis-emphysema syndrome idiopathic pulmonary fibrosis pulmonary emphysema pulmonary fibrosis syndromic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Combined pulmonary fibrosis and emphysema syndrome Emphysema Healthy subjects Pulmonary fibrosis

Contacts and locations

Locations

  • Hôpital Albert Michallon, CHU de Grenoble

    Grenoble, 38 043, France

  • Hôpital Nord, CHU de Saint-Etienne

    Saint-Etienne, 42055, France

  • Hôpital pneumologique et cardiovasculaire Louis Pradel, HCL

    Bron, 69677, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.