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Smoking and drinking leave genetic marks in mouth cells that may lead to cancer

NCT ID NCT06094829

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 100 healthy adults to see how tobacco and alcohol use cause genetic changes in cells lining the mouth. Researchers collected cheek cells using a gentle brush and searched for mutations linked to oral cancer. The goal was to understand how these substances might drive early cancer development, but the study does not provide any direct diagnosis or treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify early genetic changes linked to oral cancer, potentially improving future screening or prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot diagnose cancer or predict individual risk, and results may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Nov 2023

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects coming to odontology practices for routine visits

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Man or woman aged 18 or more. * Subject coming to odontology practice for routine visit. * Subject having accepted to participate to the research by oral non-opposition * Subject having given additional written consent for genetic studies. * Smoking group criterion: subjects having smoked 100+ cigarettes/joints during their life. Exclusion Criteria: * Personal history of cancer, whichever the type. * Treatment with anticoagulants or platelet aggregation inhibitors. * Bilateral lesions of the inner cheek preventing painless biological sample collection. * Subject under under guardians or curators * Pregnancy or breastfeeding * Cannabis usage

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Conditions

The condition(s) this trial relates to.

squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carcinoma, squamous cell

Contacts and locations

Locations

  • Cabinet Libéral Balayre

    Chassieu, 69680, France

  • Cabinet Libéral Bondil

    Villefranche-sur-Saône, 69400, France

  • Cabinet Libéral Calvo

    Quint-Fonsegrives, 31130, France

  • Cabinet Libéral Cougot

    Meudon, 92190, France

  • Cabinet Libéral Debeauvais

    Châtillon-Coligny, 45230, France

  • Cabinet Libéral Dutour

    Theix, 63122, France

  • Cabinet Libéral Finet

    Fontaine-lès-Dijon, 21121, France

  • Cabinet Libéral Glomet

    Saumur, 49400, France

  • Cabinet Libéral Grammatica

    Lyon, 69008, France

  • Cabinet Libéral Jaeggy

    Haguenau, 67500, France

  • Cabinet Libéral Janisset-Masse

    Villiers-sur-Marne, 95350, France

  • Cabinet Libéral Masri

    Vandœuvre-lès-Nancy, 54500, France

  • Cabinet Libéral Picquendar

    Bougival, 78380, France

  • Centre de Consultations et de Traitements Dentaires HCL

    Lyon, 69007, France

  • Unité de chirurgie et médecine orales (UCMO) - HCL - Hôpital Edouard Herriot- Pavillon R

    Lyon, 69003, France

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