CARCINOMA, SQUAMOUS CELL

This study tests a new drug called NBTXR3 that is injected into tumors to make radiation therapy more effective. It is for adults aged 60 and older with advanced head and neck cancer who cannot receive standard chemotherapy. The trial will compare the combination of NBTXR3 plus r…

This study tests an experimental drug called N17350 for adults with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into tumor lesions every two weeks for up to 12 weeks. Researchers aim to find the safest and most effective dos…

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or control advanced anal or rectal cancer that has spread and no longer responds to standard chemotherapy. About 35 adults with this type of cancer will receive the combination. The goal is to see how ma…

This early-phase study tests a new three-drug combination for people with head and neck cancer that has come back or spread. The goal is to find the safest dose and see if the treatment can shrink tumors or slow the disease. About 36 adults with this type of cancer will take part…

This study looks at a blood test that measures tiny bits of tumor DNA in people with head and neck cancer. Researchers want to see how these levels change after surgery and whether they can help predict if the cancer will come back. About 50 adults planning surgery will provide b…

This study looks at whether a feature called tumor budding can guide doctors in deciding if neck lymph node removal is necessary for early-stage oral cancer. About 524 patients will be followed for five years to compare survival and quality of life between those who get the stand…

This study follows 220 people with HPV-related throat cancer after treatment to see if two things can predict if the cancer returns: changes in certain genes (TRAF3 and CYLD) and levels of HPV DNA in the blood. Participants will give blood samples and have regular CT scans. The g…