Smoking and drinking leave genetic marks in mouth cells that may lead to cancer

NCT ID NCT06094829

Completed Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 100 healthy adults to see how tobacco and alcohol use cause genetic changes in cells lining the mouth. Researchers collected cheek cells using a gentle brush and searched for mutations linked to oral cancer. The goal was to understand how these substances might drive early cancer development, but the study does not provide any direct diagnosis or treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify early genetic changes linked to oral cancer, potentially improving future screening or prevention strategies.
What could go wrong: This is an observational study, not a treatment trial. It cannot diagnose cancer or predict individual risk, and results may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, SQUAMOUS CELL

Contacts and locations

Locations

Cabinet Libéral Balayre

Chassieu, 69680, France
Cabinet Libéral Bondil

Villefranche-sur-Saône, 69400, France
Cabinet Libéral Calvo

Quint-Fonsegrives, 31130, France
Cabinet Libéral Cougot

Meudon, 92190, France
Cabinet Libéral Debeauvais

Châtillon-Coligny, 45230, France
Cabinet Libéral Dutour

Theix, 63122, France
Cabinet Libéral Finet

Fontaine-lès-Dijon, 21121, France
Cabinet Libéral Glomet

Saumur, 49400, France
Cabinet Libéral Grammatica

Lyon, 69008, France
Cabinet Libéral Jaeggy

Haguenau, 67500, France
Cabinet Libéral Janisset-Masse

Villiers-sur-Marne, 95350, France
Cabinet Libéral Masri

Vandœuvre-lès-Nancy, 54500, France
Cabinet Libéral Picquendar

Bougival, 78380, France
Centre de Consultations et de Traitements Dentaires HCL

Lyon, 69007, France
Unité de chirurgie et médecine orales (UCMO) - HCL - Hôpital Edouard Herriot- Pavillon R

Lyon, 69003, France

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