Do Kids' immune systems crash like Adults' after severe infection? new study investigates
NCT ID NCT02848144
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether children with severe infectious shock develop immune suppression, similar to what is seen in adults. Researchers measured immune markers in 105 children admitted to intensive care and compared them to healthy children having surgery. The goal was to understand how the immune system responds and whether this affects recovery and risk of additional infections.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could confirm that children with severe infectious shock develop immune suppression similar to adults, guiding future treatments.
- What could go wrong
- This is an observational study with only 105 participants, so results may not apply to all children. It does not test any treatment, so direct benefits are unlikely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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105 people
The number who actually took part.
- Started
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Sep 2014
- Finished
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Aug 2018
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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1 month to 17 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria Infectious shock group: * Children aged from 1 month to \<18 years * Diagnosis of severe infectious shock at PICU or within the first 24 hours following PICU admission: severe sepsis or septic shock, defined by Surviving Sepsis Campaign 2012, or Toxic Shock Syndrome, defined by CDC criteria. Inclusion Criteria Control group: * Healthy children aged matched to cases * Hospitalized for an elective surgery (dental, ENT, maxillofacial, urologic, hernia surgery, neurosurgery without massive hemorrhage) * Without any criteria of infection. Exclusion Criteria (both groups): * Chronic inflammatory disease; * Immunodeficiency; * Long-term corticosteroids; * Ongoing immunosuppressive treatment; * Transplanted patients; * Tumors, hematological diseases; * No health insurance coverage; * Refusal to participate (from parents and/or patient) or inability to understand information.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospices Civils de Lyon
Lyon, France