Brain games reveal why epilepsy patients skip meds
NCT ID NCT02441478
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This study looks at how frontal lobe epilepsy changes cooperative behavior and decision-making. Researchers will have 30 patients and 30 healthy volunteers play a classic economic game called the Prisoner's Dilemma while their brain activity is measured with fMRI. The goal is to see if brain differences in people with epilepsy relate to how well they follow their medication plans.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could help explain why some people with epilepsy struggle to take their medication, pointing toward new ways to improve treatment adherence.
- What could go wrong
- This is a small, observational study with only 30 participants. It does not test a treatment, so any insights are preliminary and may not apply to all epilepsy patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Start date
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Feb 2015
- Finished
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Sep 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria (Patients): * Age between 18 and 50 * Diagnosis of frontal lobe epilepsy * Written consent to participate * Right-handed * Hospital Anxiety and Depression Scale Score under 10 * Obsessive Compulsive Inventory Score under 40 * Sufficient language skills * Social insurance Inclusion criteria (controls): * Age between 18 and 50 * Written consent to participate * Right-handed * Hospital Anxiety and Depression Scale Score under 10 * Obsessive Compulsive Inventory Score under 40 * Sufficient language skills * Social insurance Exclusion Criteria (Patients): * Seizures types other than epileptic (psychogenic etc.) * Mental retardation * Epilepsies other than FLE * Other known neurological diseases * Hospital Anxiety and Depression Scale Score over 10 * Obsessive Compulsive Inventory Score over 40 * Pregnancy * non-MRI suitable transplants (cardiac pacemaker etc.), claustrophobia, orthopedic diseases that prevent lying in the scanner * During exclusion period of other studies * No social insurance Exclusion criteria (controls) * History of neurological or psychiatric diseases * Hospital Anxiety and Depression Scale Score over 10 * Obsessive Compulsive Inventory Score over 40 * Medication other than contraceptives * Pregnancy * non-MRI suitable transplants (cardiac pacemaker etc.), claustrophobia, orthopedic diseases that prevent lying in the scanner * Major perceptive impairments * During exclusion period of other studies * No social insurance
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospices Civils de Lyon
Lyon, 69002, France