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Tailored chemo regimens tested for frail ovarian cancer patients

NCT ID NCT02001272

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 120 vulnerable women over 70 with advanced ovarian cancer. It compared three chemotherapy plans: standard two-drug therapy every three weeks, a single drug every three weeks, or a weekly two-drug schedule. The goal was to see which plan allowed patients to complete six cycles without severe side effects or stopping early.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

120 people

The number who actually took part.

Started

Dec 2013

Finished

Feb 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

70 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Woman \>70 year old * Histologically or cytologically proven FIGO stage III to IV epithelial ovarian cancer or peritoneal primary or fallopian tube. A cytological proof is accepted if associated with a ratio of CA125/CEA \>25 and a radiological pelvic mass. * GVS (Geriatric Vulnerability Score) \>3. * Adequate bone marrow function including the following: Neutrophils ≥ 1.5 x 109/L , platelets ≥100 x 109/L and hemoglobin ≥9 g/dL. * Adequate glomerular filtration rate \>40 ml/min (estimates based on MDRD or Chatelut formula are sufficient) * No icterus. * Life expectancy \> 3 months. * Written informed consent obtained. * Covered by a Health System where applicable Exclusion Criteria: * Other malignancy within the last 5 years, except for adequately treated carcinoma in situ of the cervix or squamous carcinoma of the skin, or adequately controlled limited basal cell skin cancer. * Prior history of chemotherapy. * Prior history of radiotherapy which may affect patient tolerability to chemotherapy. * Major perturbations of liver biology: Bilirubin \> 2 fold the upper normal limit (UNL), SGOT-SGPT \> 3 fold UNL. * Patient unable to be regularly followed for any reason (geographic, familial, social, psychologic). * Any mental or physical handicap at risk of interfering with the appropriate treatment. * Known allergy to Cremophor ® EL -containing drugs. * Any administrative or legal supervision where applicable

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer ovarian cancer primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ovarian cancer

Contacts and locations

Locations

  • Azienda Ulss 21 Legnago

    Legnago, Italy

  • Centre CARIO - Hôpital Privé des Côtes d'Armor

    Plerin Sur Mer, 22190, France

  • Centro di Riferimento Oncologico - CRO,IRCCS

    Aviano, Italy

  • Fondazione IRCCS Istituto Nazionale Tumori

    Milan, Italy

  • Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo

    Torino, Italy

  • Herlev Hospital

    Herlev, Denmark

  • Kuopio University Hospital

    Kuopio, Finland

  • Linköping University Hospital

    Linköping, Sweden

  • Notre-Dame Hospital of the CHUM

    Montreal, Canada

  • Ospedale Nuovo di Sassuolo

    Sassuolo, Italy

  • Servicde d'Oncologie Médicale - Centre Hospitalier Régional d'Orléans

    Orléans, 45067, France

  • Service d''Hématologie Oncologie - Hôpital André Mignot

    Le Chesnay, 78157, France

  • Service d'Onco-Hématologie - Centre Antoine Lacassagne

    Nice, 06186, France

  • Service d'Onco-Hématologie - Hôpital Fleyriat

    Bourg-en-Bresse, 01012, France

  • Service d'Oncologie - Centre Hospitalier Alpes Leman

    Contamines Sur Arve, 74130, France

  • Service d'Oncologie - Centre Hospitalier de Chambéry

    Chambéry, 73011, France

  • Service d'Oncologie - Groupe Hospitalier Saint-Joseph

    Paris, 75674, France

  • Service d'Oncologie - Hôpital Cochin

    Paris, 75014, France

  • Service d'Oncologie - Hôpital Dupuytren

    Limoges, 87042, France

  • Service d'Oncologie Médicale - Centre Azuréen de Cancérologie

    Mougins, 06250, France

  • Service d'Oncologie Médicale - Centre Georges François Leclerc

    Dijon, 21079, France

  • Service d'Oncologie Médicale - Centre Hospitalier Yves le Foll

    Saint-Brieuc, 22015, France

  • Service d'Oncologie Médicale - Centre Hospitalier d'Alès

    Alès, 30100, France

  • Service d'Oncologie Médicale - Centre Hospitalier de Cholet

    Cholet, 49300, France

  • Service d'Oncologie Médicale - Centre Hospitalier de Perpignan

    Perpignan, 66046, France

  • Service d'Oncologie Médicale - Centre Hospitalier de Sens

    Sens, 89108, France

  • Service d'Oncologie Médicale - Centre Jean Bernard - Clinique Victor Hugo

    Le Mans, 72000, France

  • Service d'Oncologie Médicale - Centre Paul Strauss

    Strasbourg, 67065, France

  • Service d'Oncologie Médicale - Centre d'Oncologie et de Radiothérapie du Parc

    Dijon, 21000, France

  • Service d'Oncologie Médicale - Clinique Mutualiste de l'Estuaire, Cité Sanitaire

    Saint-Nazaire, 44600, France

  • Service d'Oncologie Médicale - Groupe Hospitalier Public du Sud de l'Oise - Site de Senlis

    Senlis, 60309, France

  • Service d'Oncologie Médicale - Hôpital Européen Georges Pompidou

    Paris, 75908, France

  • Service d'Oncologie Médicale - Hôpital Michallon - CHU Grenoble

    Grenoble, 38043, France

  • Service d'Oncologie Médicale - Hôpital des Diaconesses

    Paris, 75012, France

  • Service d'Oncologie Médicale - ICO Centre René Gauducheau

    Saint-Herblain, 44805, France

  • Service d'Oncologie Médicale - ICO Paul Papin

    Angers, 49100, France

  • Service d'Oncologie Médicale - Institut Bergonié

    Bordeaux, 33076, France

  • Service d'Oncologie Médicale - Institut Claudius Regaud

    Toulouse, 31300, France

  • Service d'Oncologie Médicale - Institut Paoli Calmettes

    Marseille, 13273, France

  • Service d'Oncologie Médicale - Institut Régional du Cancer Montpellier, Val d'Aurelle

    Montpellier, 34298, France

  • Service d'Oncologie Médicale - Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54519, France

  • Service d'Oncologie Radiothérapie - Centre Hospitalier Intercommunal de Créteil

    Créteil, 94010, France

  • Service d'Oncologie Radiothérapie - Centre Hospitalier Privé de Saint-Grégoire

    Saint-Grégoire, 35760, France

  • Service d'Oncologie Radiothérapie - Clinique de Valdegour

    Nîmes, 30900, France

  • Service d'Oncologie Service 2 B Nord - Centre Léon Bérard

    Lyon, 69373, France

  • Service d'Oncologie multidisciplinaire - Hôpital Nord

    Marseille, 13915, France

  • Service d'Uro-Gynécologie - Centre François Baclesse

    Caen, 14076, France

  • Service de Chimiothérapie - Centre Catherine de Sienne

    Nantes, 44202, France

  • Service de Chirurgie et Oncologie Gynécologique et Mammaire - Hôpitaux du Léman

    Thonon-les-Bains, 74203, France

  • Service de Médecine Gériatrique - Centre Hospitalier Intercommunal des Alpes du Sud -Site de Gap

    Gap, 05000, France

  • Service de Médecine Interne et Oncologie Médicale - CH du Mans

    Le Mans, 72000, France

  • Service de Médecine Oncologique - Institut de Cancérologie Gustave Roussy

    Villejuif, 94800, France

  • Service de Médecine interne et oncologie - Hôpital Inter Armées de Begin

    Saint-Mandé, 94163, France

  • Service de Radiothérapie et Oncologie Médicale - Hôpital Morvan

    Brest, 29200, France

  • Service de cancérologie clinique - Institut Sainte-Catherine

    Avignon, 84918, France

  • Service oncogériatrie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon

    Pierre-Bénite, 69495, France

  • Servide d'Oncologie Médicale - Centre Hospitalier de la Région d'Annecy

    Pringy, 74374, France

  • Servide d'Oncologie Médicale - Centre Jean Perrin

    Clermont-Ferrand, 63000, France

  • Servide d'Oncologie Médicale - Hôpital Jean Minjoz

    Besançon, 25030, France

  • Servide d'Oncologie Médicale - Institut Jean Godinot

    Reims, 51056, France

  • Servide de Radiothérapie et Oncologie Médicale - Centre Hospitalier Intercommunal de Cornouaille

    Quimper, 29107, France

  • Ulls13 - Mirano

    Mirano, Italy

  • service d'Oncologie Médicale - Centre Hospitalier Broussais

    St-Malo, 35403, France

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