OVARIAN CANCER

This study is testing whether adding surgery after chemotherapy helps control recurrent ovarian cancer better than chemotherapy alone. It will enroll 80 women whose ovarian cancer has returned but is still responding to platinum-based drugs. Researchers will compare how long pati…

This is the first study in humans testing a new drug called TORL-1-23 for people with advanced solid tumors, including ovarian, endometrial, and lung cancers. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs it might help …

This early-stage trial is testing a new cancer drug called TUB-040 in people with advanced ovarian cancer or a type of lung cancer that has stopped responding to standard treatments. The drug works like a 'smart bomb'—it's designed to find cancer cells and deliver a powerful chem…

This early-stage trial is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful, short-range form of radiation dir…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have returned or spread. The therapy, called Tmod CAR T cells, is designed to find and kill cancer cells while trying to avoid harming the patient's healthy cells. Researchers…

This early-stage study is testing a new cell therapy for people with advanced ovarian or pancreatic cancer that has stopped responding to standard chemotherapy. Researchers are modifying natural killer (NK) immune cells from donated cord blood to better recognize and attack cance…

This is the first study in people to test a new oral medication called NKT3964. The main goals are to find a safe dose and see if the drug shows early signs of shrinking tumors in adults with advanced cancers that have spread and no longer respond to standard treatments. The stud…

This study is testing if a fecal microbiota transplant (FMT) can safely and effectively treat severe diarrhea and colon inflammation caused by immunotherapy drugs in cancer patients. The treatment involves transferring stool from a healthy donor into the patient's colon during a …

This is an early-stage study testing the safety of a new treatment called IVX037, which is injected directly into tumors. It is for people with advanced colorectal, gastric, or ovarian cancer that has stopped responding to standard treatments. The study has two parts: first testi…

This study aims to improve a treatment for cancer that has spread to the lining of the abdomen. The treatment involves surgery to remove tumors, followed by a heated chemotherapy wash inside the abdomen. Researchers will test different chemotherapy drugs on tumor samples in the l…

This is an early safety study testing a new treatment called THEO-260 for women with advanced ovarian cancer that has stopped responding to standard platinum chemotherapy. The main goal is to find a safe dose and see what side effects occur. Participants will receive six doses of…

This study is testing a personalized cancer vaccine made from a patient's own tumor cells. The cells are modified in a lab to train the immune system to attack the cancer, then injected back into the patient. The trial is for adults with advanced cancers that have spread and who …

This study is observing how well the drug T-DXd works for people with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients in real-world US clinics to see how their tumors respond and how long the …

This study is testing whether adding a targeted drug called olaparib to a specialized surgery improves outcomes for advanced ovarian cancer. During surgery, doctors wash the abdomen with heated chemotherapy (HIPEC). Researchers want to see if taking olaparib pills for a week befo…

This study is for women whose ovarian cancer has returned but responded well to a second round of platinum chemotherapy. It tests if adding a newer, targeted drug (mirvetuximab soravtansine) to a standard maintenance drug (bevacizumab) can keep the cancer controlled longer and pr…

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific genetic marker called HER2. The trial will enroll about 200 adults whose cancers have progressed after at least one prior treatment. Researchers want to see if the …

This study is testing an experimental drug called ubamatamab for women with advanced ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to standard platinum-based chemotherapy. The goal is to see if the drug is safe and effective when given alone or…

This early-stage study is testing a new drug called XMT-1660 in people with advanced solid tumors that have returned or spread. The main goals are to find a safe dose and see what side effects occur. Researchers will enroll about 319 participants with cancers including triple-neg…

This study is testing a combination of two oral drugs, fuzuloparib and apatinib, as a treatment given before surgery for advanced ovarian cancer. The goal is to see if this 'de-chemotherapy' approach can shrink tumors enough to allow for more successful surgery, aiming to improve…

This study is testing a new type of immune cell therapy called EBNK-001 for people with advanced solid tumors that have stopped responding to standard treatments. Participants receive 'off-the-shelf' natural killer (NK) cells from a donor after a short course of chemotherapy, wit…

This is a first-in-human study to test the safety and early effectiveness of a new investigational drug called BL-B01D1. It is for adults with advanced or spreading cancers, including lung, breast, and several other solid tumors, who have few treatment options left. The main goal…

This early-stage trial is testing a new oral drug called MOMA-313, given alone or combined with an existing cancer drug (olaparib), in people with advanced solid tumors that have a specific genetic flaw. The main goals are to find safe doses and see how the body processes the dru…

This study is testing whether a combination of three drugs can help control recurrent ovarian cancer. It will involve about 20 adults whose cancer has returned after initial treatment. The main goals are to see if the treatment shrinks tumors and to understand what side effects p…

This early-stage trial is testing a new drug called SYS6043 in adults with advanced solid tumors that have spread or stopped responding to standard treatments. The main goals are to find the safest dose, understand side effects, and see how the drug moves through the body. Resear…

This is the first study in people testing a new oral medication called NKT5097 for adults with advanced or metastatic solid tumors, with a focus on certain breast, ovarian, and uterine cancers. The main goals are to find a safe dose, see how the body processes the drug, and check…

This early-stage study is testing a new cell therapy called FT536 for women with recurrent ovarian, fallopian tube, or primary peritoneal cancer. The therapy involves collecting and modifying a patient's own immune cells, then giving them back directly into the abdomen. The main …

This study is testing a new type of personalized cell therapy for adults with advanced cancers that have a specific marker called CD70. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then infuse them back int…

This study is testing a new combination treatment for patients with advanced ovarian, fallopian tube, or primary peritoneal cancer. It aims to see if adding a targeted drug called mirvetuximab soravtansine to standard chemotherapy before surgery is feasible and effective. The tre…

This study is testing whether adding an experimental drug called LBL-024 to standard chemotherapy (paclitaxel) works better for ovarian cancer that has stopped responding to platinum-based drugs. About 110 adults with advanced ovarian cancer will receive either the combination or…

This study is testing whether adding a newer targeted drug (trastuzumab deruxtecan) to an existing maintenance drug (bevacizumab) works better than the existing drug alone to keep ovarian cancer from returning. The trial involves 582 adults with advanced ovarian cancer who have j…

This early-stage trial is testing a new virus-based therapy called THEO-260 for women with advanced ovarian cancer that has stopped responding to standard platinum chemotherapy. The main goals are to find the safest and most effective dose and to see if the treatment shows signs …

This large, late-stage study is testing whether adding an investigational drug called Rina-S to standard care helps control recurrent ovarian cancer for longer after second-line chemotherapy. It will enroll about 528 women whose cancer returned more than 6 months after their firs…

This study is testing whether new maintenance drugs can help women with recurrent ovarian cancer live longer without their cancer getting worse. After completing standard chemotherapy, participants will receive either the new drug combinations or standard care to see which works …

This study is testing whether the oral drug belzutifan can help control recurrent clear cell cancers of the ovary, uterus, cervix, and other gynecologic sites. It will enroll 32 adults who have already received platinum-based chemotherapy. Researchers will measure how well the dr…

This is a first-in-human safety study testing a single dose of an experimental cell therapy called SynKIR-110. It is for adults with advanced ovarian cancer, bile duct cancer, or mesothelioma that has come back after prior treatment. Doctors will collect a patient's own immune ce…

This early-stage study is testing if adding aspirin to standard chemotherapy helps the body's immune system better fight ovarian, fallopian tube, or peritoneal cancer. It will involve 100 adults who are scheduled for chemotherapy before surgery. Researchers will measure changes i…

This early-stage trial is testing a new oral drug called KESONOTIDE in people with advanced solid tumors that have spread. The main goal is to find a safe dose and see how well the body handles the medicine. About 80 adults with cancers like prostate, breast, lung, ovarian, and o…

This study is testing different combinations of an experimental drug called mirvetuximab soravtansine with two other cancer drugs (carboplatin or bevacizumab) for ovarian cancer. It aims to find the safest and most effective doses for patients whose tumors have a specific marker.…

This early-stage study is testing a new drug called IDE161, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors that have spread. The main goals are to find safe doses and see if the treatment shows early signs of shrinkin…

This study is testing a new type of cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors will analyze a patient's tumor to select a specific target, then infuse specially engineered immune cells (CAR-NK cells) from a heal…

This early-stage study is testing whether an experimental drug called NRM-823 is safe and can help control advanced cancers that have stopped responding to standard treatments. Researchers will give NRM-823 alone and combined with immunotherapy to about 150 adults with various so…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This study aims to understand how a maintenance drug called niraparib works in women of African ancestry who have ovarian cancer. Researchers want to see if genetic background affects the drug's safety, side effects, and how the body processes it. The goal is to help control the …

This study is testing whether combining three existing drugs—pembrolizumab, bevacizumab, and low-dose cyclophosphamide—can help control high-grade ovarian cancer that is still present in small amounts after a patient's first round of treatment. The goal is to see if this combinat…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This early-stage trial is testing a new drug called AZD8205, both by itself and combined with other cancer drugs, for people with advanced solid tumors that have spread or returned. The main goals are to find safe doses and see if the treatments can shrink tumors. It is enrolling…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This is the first study in people to test a new oral drug called ATX-295, which works by blocking a specific protein that helps cancer cells divide. The main goals are to find a safe dose and see how the body processes the drug in about 90 patients with advanced solid tumors, inc…

This is the first human study of LNCB74, a new targeted cancer drug designed to deliver chemotherapy directly to cancer cells. Researchers will test different doses in 145 adults with advanced solid tumors (including ovarian, breast, lung, and other cancers) to find the safest an…

This early-stage study is testing the safety and initial effects of a new drug called SYN818 when given with an existing cancer drug, olaparib. It is for adults with advanced or metastatic solid tumors (like ovarian or breast cancer) that have specific genetic changes (BRCA mutat…

This is the first human study of a new experimental cancer drug called HWK-007. Researchers are testing it in adults with advanced ovarian, endometrial, or non-small cell lung cancers that have stopped responding to standard treatments. The main goals are to find the safest dose …

This early-stage trial is testing a new radioactive drug called 177LuBetaBart in adults with advanced solid cancers that have stopped responding to standard treatments. The study aims to find a safe dose and see if the drug shows early signs of fighting tumors. Participants will …

This study is testing a new combination treatment for advanced ovarian cancer. It pairs a standard chemotherapy drug (carboplatin) with a newer, targeted drug called Distamab Vedotin (RC48), which is designed to attack cancer cells with a specific marker (HER2). The goal is to se…

This early-stage study is testing a new cell-based therapy called SY001 in people with advanced ovarian or pancreatic cancer that has not responded to prior treatments. The main goals are to find a safe dose, see how the body handles the treatment, and check for any early signs t…

This study is testing a new oral drug called ART0380 in people with advanced or metastatic solid tumors that have spread and are hard to treat. The main goals are to find the safest and most effective dose of ART0380 when given alone or combined with standard chemotherapy drugs, …

This study is testing a multi-step treatment plan for people newly diagnosed with advanced ovarian cancer. It combines standard chemotherapy with an immunotherapy drug before surgery, followed by a targeted therapy pill and immunotherapy as long-term maintenance. The main goal is…

This study is testing an experimental drug called INCB123667 for women with platinum-resistant ovarian cancer whose tumors have a specific marker called cyclin E1 overexpression. The trial aims to see if the drug is safe and can shrink tumors in 160 participants who have tried 1-…

This is the first human study of an experimental oral drug called AOH1996 for patients with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and understand how the body processes the drug. Researchers will enrol…

This study is testing whether freezing gonadal tissue (ovarian or testicular tissue) is a safe and effective way to preserve fertility or future hormone function. It is for young people under 30 with a disorder of sex development (DSD) who are at risk of infertility or need their…

This is the first study in people testing an experimental drug called CUSP06. It aims to see if the drug is safe and can help control advanced ovarian cancer and other solid tumors that have stopped responding to standard platinum-based chemotherapy. The study will enroll about 2…

This is an early, small study to see if a personalized cell-based vaccine is safe and can trigger an immune response in patients with recurrent ovarian cancer. Doctors will take a sample of the patient's tumor to create a custom vaccine, which is then injected back into the patie…

This study is testing an experimental drug called HLX43 for women with advanced cervical or ovarian cancer that has returned or spread after standard first treatments didn't work or caused severe side effects. The Phase 2 trial will enroll about 130 participants to find the right…

This is the first study in humans to test the safety and find the right dose of a new drug called XmAb541 for people with advanced solid tumors, including ovarian, endometrial, and germ cell cancers. The main goal is to see how well the drug is tolerated and to check for side eff…

This early-stage study is testing a new type of treatment for ovarian cancer that has come back and stopped responding to standard platinum-based chemotherapy. Researchers are collecting a patient's own immune cells, boosting them in a lab to create 'memory-like' natural killer (…

This study is testing a new immunotherapy for advanced ovarian cancer. Doctors take a patient's own immune cells, genetically modify them to better recognize and attack ovarian cancer, then infuse them back into the body. The trial aims to determine if this approach is safe and e…

This early-stage study is testing the safety of a new treatment for ovarian cancer that has returned after previous therapies. Doctors take a patient's own immune cells (T cells), modify them in a lab to better recognize cancer, and then infuse them back into the body. The main g…

This study is testing whether a pre-surgery support program helps women with ovarian or endometrial cancer recover better. The program includes exercise, nutritional advice, and psychological support before their operation. Researchers will compare patients who receive this extra…

This early-stage study is testing a new type of personalized immune cell therapy (CAR-T) for people with advanced solid tumors that have a specific marker called CD70. The main goals are to find a safe dose and see how the body handles the treatment. It is for adults with cancers…

This early-stage trial is testing a new personalized cell therapy called OPB-101 for women with ovarian cancer that has stopped responding to standard platinum-based chemotherapy. Doctors will modify a patient's own immune cells in a lab to target the cancer and then infuse them …

This early-stage study is testing FT836, a new type of 'off-the-shelf' CAR T-cell therapy, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the body tolerates FT836, which is given al…

This study is testing whether a new drug called HS-20089 works better than standard chemotherapy for women with ovarian cancer that has returned and stopped responding to platinum-based drugs. About 468 participants will be randomly assigned to receive either the experimental dru…

This early-stage trial is testing a new type of personalized immune cell therapy called B7-H3 CAR-T cells in adults with ovarian cancer that has returned and stopped responding to standard platinum chemotherapy. The study aims to find the safest dose and see if these modified imm…

This early-stage study aims to find the safest and most effective dose of an experimental drug called DT2216 when given with standard chemotherapy (paclitaxel) for women with recurrent ovarian cancer that has stopped responding to platinum-based treatments. The trial will enroll …

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This is a first-in-human study testing a new personalized cell therapy called NT-175. It is for adults with advanced solid cancers (like lung, colorectal, or breast cancer) that have spread and have a specific genetic mutation (TP53 R175H). The main goals are to find a safe dose …

This study is testing new immunotherapy drug combinations for women with advanced ovarian cancer that has stopped responding to standard platinum-based chemotherapy. Researchers will enroll 60 participants to see if these experimental treatments can shrink tumors and extend life …

This study is evaluating the safety and performance of the Medtronic Hugo robotic surgery system when used to perform hysterectomies. It will enroll about 70 adult women who need this surgery for various conditions, including fibroids, endometriosis, and certain cancers. The main…

This early-stage study is testing a new drug called APL-5125 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and see if the drug can shrink tumors, especially in colorectal canc…

This study is testing a new drug, SHR-A1811, combined with standard chemotherapy for ovarian cancer that has returned but still responds to platinum drugs. The main goals are to find the safest and most effective dose and to see how well the combination works to control the cance…

This early-stage trial is testing whether adding a new drug called lurbinectedin to two existing cancer drugs (paclitaxel and bevacizumab) can help control advanced ovarian cancer that has stopped responding to standard platinum-based chemotherapy. The study will enroll 34 women …

This study is testing a new oral drug called ACE-86225106 to see if it is safe and can help control advanced solid tumors in adults. It is for people with cancers like ovarian, breast, or prostate cancer that have not responded well to standard treatments. The main goals are to f…

This study is testing a new experimental drug, REGN5668, alone and in several combinations with other cancer drugs, for people with advanced ovarian, fallopian tube, peritoneal, or uterine cancers that have progressed after standard treatments. The main goals are to find the safe…

This study aims to see if a new drug called DWZ2501 behaves the same way in the body as an existing drug (DWC202510) for patients with advanced ovarian cancer linked to a BRCA gene change. It will involve about 40 women who are already taking or need to start the existing drug. T…

This trial is testing whether an experimental antibody called COM701 can help control ovarian cancer that has returned after previous treatment. The study will involve 60 participants with relapsed platinum-sensitive ovarian cancer who will receive either COM701 or a placebo thro…

This study is testing whether a new targeted drug called sacituzumab tirumotecan (Sac-TMT), given alone or with another drug called bevacizumab, can help people with advanced ovarian cancer live longer without their cancer getting worse. It compares these new maintenance treatmen…

This study is testing a special support program designed to help older women with advanced ovarian cancer better withstand and recover from major surgery. The program includes nutritional advice, physical exercise, and education before surgery, followed by coordinated care during…

This study is for people with advanced ovarian cancer who have had successful surgery to remove all visible tumor. It aims to find out if receiving 3 cycles of standard chemotherapy, followed by a maintenance drug called niraparib, is as effective at preventing the cancer from co…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This is the first human study testing an experimental drug called ABBV-901 for advanced ovarian cancer that has stopped responding to standard platinum-based chemotherapy. Researchers will enroll about 207 people to test the safety, side effects, and early signs of effectiveness …

This study is testing a new, experimental cancer drug called AZD5335 to see if it is safe and if it can help control advanced cancers. It will be given alone and in combination with other cancer drugs to adults with ovarian, lung, or endometrial cancers that have progressed despi…

This early-stage study is testing a new drug called NMS-03305293 combined with an existing chemotherapy (topotecan) for women with recurrent ovarian cancer. The main goals are to find the safest dose and see how well patients tolerate the combination. Researchers will also check …

This study aims to find the safest and most effective dose of a new drug, sacituzumab govitecan, when combined with an existing chemotherapy drug, cisplatin. It is for women whose ovarian or endometrial cancer has returned but responded well to platinum-based chemotherapy in the …

This is an early-stage trial testing a new drug called BI-1808 for people with advanced cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the body tolerates the drug, both by itself and when combined with an exist…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This study is testing if adding an experimental drug called IMNN-001 to standard chemotherapy and bevacizumab is safe and more effective at controlling advanced ovarian, fallopian tube, or primary peritoneal cancer. Researchers will compare the two-drug standard treatment to the …

This study is testing whether a new drug called INCB123667 works better than standard chemotherapy for women with a specific type of advanced ovarian cancer that has stopped responding to platinum-based drugs. It will involve about 466 participants whose cancer has a specific bio…

This large international study is testing which treatment strategy works better to control advanced ovarian, fallopian tube, or peritoneal cancer after initial chemotherapy. It compares taking the drug niraparib alone versus taking niraparib plus another drug called bevacizumab. …

This early-stage study is testing a new oral medication called INX-315 in people with advanced cancers that have spread or stopped responding to standard treatments. It aims to find a safe dose and see if the drug can help control cancers like certain types of breast and ovarian …

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for women with ovarian cancer that has returned and is resistant to standard platinum-based chemotherapy. Doctors will collect a patient's own immune cells, modify them in a lab to better target t…

This is the first human study of an experimental drug called SLV-154 for people with advanced solid tumors that have spread. The main goal is to find the highest safe dose and understand how the body processes the drug. About 70 adults with one of ten specific advanced cancers wh…

This study is testing a personalized cell therapy for people with metastatic cancer that has not responded to standard treatments. Doctors take a patient's own white blood cells, genetically modify them in a lab to better recognize and attack their specific cancer, and then infus…

This study is testing whether a plant-based supplement called isoquercetin can reduce markers in the blood that indicate risk of blood clots in people with ovarian cancer. Researchers will compare the effects of isoquercetin against a placebo in 90 participants who are receiving …

This study is testing whether adding an experimental drug called relacorilant to standard chemotherapy helps control advanced gynecologic cancers. It will enroll about 270 patients with ovarian, fallopian tube, peritoneal, or endometrial cancer that has returned or spread. The ma…

This study is for people with advanced ovarian cancer where the first few rounds of standard chemotherapy didn't shrink the tumor enough and surgery to remove all the cancer wasn't possible. It will test if switching to a more frequent, 'dose-dense' chemotherapy schedule is bette…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing a new drug called TER-2013 in people with advanced solid tumors that have specific genetic changes. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for patients who have run out of standard treatment options.

This study is testing a two-part treatment for women whose mucinous ovarian cancer has returned. It involves surgery to remove visible tumors, followed immediately by a heated chemotherapy solution that is circulated in the abdomen to target any remaining cancer cells. The main g…

This large study is testing whether washing the abdomen with heated chemotherapy during surgery helps people with advanced ovarian cancer live longer. It will compare surgery with the heated chemo treatment to surgery alone in 520 patients. The main goal is to see if this approac…

This is the first study in people for a new drug called BL0175. It aims to find a safe dose and see if it can help control advanced breast, ovarian, or endometrial cancers that have stopped responding to standard hormone therapies in postmenopausal women. The study will closely m…

This early-stage trial is testing a two-part personalized treatment for adults with advanced solid cancers that have spread and contain specific KRAS gene mutations. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cells w…

This study is testing whether adding two existing drugs, hydroxychloroquine and nelfinavir, to standard maintenance therapy helps control ovarian cancer longer. It will involve 38 patients whose cancer has returned but initially responded well to platinum chemotherapy. The main g…

This study is testing whether a blood conservation technique called acute normovolemic hemodilution (ANH) can reduce the need for donor blood transfusions during ovarian cancer surgery. Researchers will randomly assign 86 patients undergoing surgery for advanced ovarian cancer to…

This study is testing if a single, targeted radiation injection given directly into the abdomen after standard chemotherapy and surgery can help control advanced ovarian cancer for longer. It is for patients whose cancer has spread within the abdomen and who have a specific genet…

This large Phase 3 trial is testing whether adding a new drug called IMNN-001 to standard chemotherapy helps people with advanced ovarian, fallopian tube, or primary peritoneal cancer live longer. About 500 participants will be randomly assigned to receive either the standard che…

This is an early-stage study to check the safety and initial activity of an experimental drug called DR-0202. It is for adults with advanced cancers that have spread, returned, or stopped responding to at least two prior treatments. The main goal is to find a safe dose and see ho…

This study is testing if adding a common blood pressure drug called telmisartan to standard chemotherapy can help control ovarian cancer that has stopped responding to platinum-based drugs. It will involve about 33 patients and compare how long their cancer stays controlled to re…

This study is testing whether giving the drug niraparib again after surgery can help control ovarian cancer that has returned in a limited way. It will include 30 women whose cancer spread to 1-5 spots after previous treatment with similar drugs. The main goal is to see how long …

This study aims to develop a new test to detect endometrial, ovarian, and cervical cancers. Researchers will collect vaginal fluid and blood samples from over 3,000 women to check for specific cancer markers. The goal is to create a less invasive way to find these cancers earlier…

This study is testing a new blood test to see if it can detect the return of advanced ovarian cancer earlier than current standard methods like CT scans and other blood markers. Researchers will enroll 30 patients with newly diagnosed advanced ovarian cancer and track them over t…

This study is testing a new blood test to see if it can detect many different types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can spot cancer signals and identify where in the body the cancer started. T…

This study is testing a new diagnostic platform called the Italian Tumor Chemogenomic Profiler (IT-TCP). Researchers will analyze tumor samples from 300 patients with various high-risk cancers to see if this detailed analysis can help guide treatment choices. The goal is to see i…

This study aims to develop and validate an AI-powered blood test that can detect cancer early and monitor how well treatments are working. Researchers will analyze RNA from platelets and immune cells in blood samples from 6,000 participants, including people with various cancers …

This study is testing whether combining four different blood tests can help detect ovarian cancer earlier in women at average risk. Researchers will enroll 8,000 postmenopausal women to have regular blood draws over several years. The results will create a risk score that determi…

This study is testing a new blood test designed to detect five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will analyze tiny particles in the blood using a special light-based technique and artificial intelligence. The goal is t…

This study is testing whether a simple tampon sample can be used to find early signs of uterine or ovarian cancer. Researchers are enrolling 1,500 women who are already scheduled for surgery to remove their uterus or ovaries. They will compare DNA markers found in the tampon samp…

This study is testing a drug called Gleolan that makes ovarian cancer tumors glow under blue light during surgery. The goal is to help surgeons see and remove more cancerous tissue than they can with standard methods alone. The trial will involve about 170 women with suspected ne…

This large study is testing whether regular vaginal ultrasound screenings can help find ovarian cancer earlier in women at higher risk. It involves 65,000 women in Kentucky and aims to improve the accuracy of the screening test to reduce false alarms while still catching real cas…

This study is comparing two different lab tests to see which one better identifies ovarian cancer patients who are likely to respond well to chemotherapy and may benefit from a follow-up targeted drug. It involves 88 women newly diagnosed with advanced ovarian cancer. The goal is…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and education through mobile mammography units. It will enroll 1,000 underserved women in Texas who are already scheduled for mammograms on these mobile …

This study is testing whether a two-step surgery approach can safely prevent ovarian cancer in women with high-risk genetic mutations. Currently, doctors recommend removing both ovaries and fallopian tubes around age 40, which causes immediate menopause. This study will see if re…

This study is testing a new approach to prevent ovarian cancer in women with specific genetic mutations that put them at high risk. Currently, the standard prevention is to remove both fallopian tubes and ovaries at a relatively young age, which causes immediate menopause. This s…

This study is testing a new communication tool designed to help patients with advanced ovarian cancer, their caregivers, and their doctors work together to set priorities for care during clinic visits. It is a pilot study to see if the tool is practical and acceptable to use. The…

This study is testing whether a virtual mind-body program can help reduce fatigue and improve quality of life for people undergoing cancer treatment. The program includes online classes like yoga, meditation, and fitness sessions that patients can do from home. Researchers want t…

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study is testing whether a special type of supportive talk therapy, called CALM, is practical and helpful for people dealing with the emotional stress of a new or returning advanced ovarian cancer diagnosis. It will involve about 50 participants who will answer questionnaire…

This study is testing whether a 16-week home exercise program, done over video calls, can help women with ovarian or endometrial cancer who are receiving chemotherapy after surgery. Researchers want to see if the exercise helps patients keep their leg strength and mobility, and r…

This study is testing whether drinking tart cherry juice can prevent nerve pain (neuropathy) caused by a common chemotherapy drug called paclitaxel. It will enroll 86 people with breast or ovarian cancer who are starting this type of chemo. Participants will be randomly assigned …

This study is testing if a special exercise and nutrition program, started during chemotherapy before surgery, can help older adults with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick to the program and if it helps them get stronger, improve thei…

This study is testing a telehealth program called REVITALIZE to see if it can help reduce the severe fatigue that often interferes with daily life for people with advanced ovarian cancer who are taking PARP inhibitor medications. About 240 participants will be randomly assigned t…

This study is testing a comprehensive yoga therapy program for women with ovarian cancer who are scheduled for chemotherapy and surgery. Researchers want to see if this lifestyle program is practical to implement and if it helps improve patients' quality of life, physical conditi…

This study is preparing for future cancer treatment trials by collecting information and materials from patients. Researchers will analyze tumor tissue from people with advanced solid tumors and collect their white blood cells through a procedure called apheresis. The collected c…

This study is testing a method to predict which cancer drugs will work best for individual ovarian cancer patients. Researchers will analyze tumor tissue samples from 60 patients with advanced ovarian cancer to see if they can identify who will respond to specific investigational…

This study aims to understand how a drug called itraconazole, often used to treat fungal infections, affects the levels of a new experimental cancer drug (AZD5335) in the body. It will involve about 24 people with advanced ovarian, fallopian tube, or primary peritoneal cancer who…

This study aims to improve how we predict who might get cancer and detect its return very early, before symptoms or scans show it. Researchers will analyze blood and tissue samples from 850 people with breast, ovarian, colorectal, lung, or skin cancer. The goal is to find genetic…

This early-stage study aims to understand the safety and radiation exposure of an experimental imaging agent called RAD301. It will involve 9 participants, including both healthy volunteers and people with certain solid tumors like pancreatic or lung cancer. Participants will rec…

This study aims to collect and store tumor tissue and blood samples from patients with several types of cancer. The goal is to create a biobank, or a library of samples, to help researchers better understand how cancer cells, their surrounding environment, and the body's immune s…

This study aims to understand if giving chemotherapy before surgery changes how fit or frail older adults with advanced ovarian or endometrial cancer feel. Researchers will measure frailty and thinking skills in about 35 participants before and after 3-4 rounds of pre-surgery che…

This research study aims to understand why some ovarian cancers stop responding to chemotherapy. Researchers will collect tumor samples, blood, and other fluids from 350 patients throughout their treatment journey. By analyzing these samples, they hope to find biological markers …

This study aims to create a large collection of blood samples from cancer patients and people at high risk for cancer. Researchers will use these samples to build a research library for future studies on 'liquid biopsies'—blood tests that can detect cancer DNA. The goal is to hel…

This study aims to see if a genetic risk score can help predict who might develop ovarian cancer. Researchers will compare the genetic scores of women with ovarian cancer to women without the disease. Participants will answer lifestyle questions and provide a blood sample for gen…

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study is testing if surgeons can safely preserve a specific artery (the left colic artery) during surgery for colon, rectal, or ovarian cancer. The goal is to see if keeping this artery open provides better blood flow to the remaining colon, which could help it heal better a…

This study aims to collect detailed genetic information and health records from 25,000 adults who have cancer or are at risk of developing it. Researchers will analyze this data to better understand how cancer develops and to identify potential targets for future treatments. The …

This study aims to better understand how specific genetic features in ovarian cancer affect how patients respond to standard treatments. It will observe 1000 women with newly diagnosed ovarian, fallopian tube, or primary peritoneal cancer across four Nordic countries. Researchers…

This study aims to improve methods for collecting and processing blood samples that could one day help detect ovarian cancer earlier. Researchers will recruit 1,500 postmenopausal women in Australia to donate blood and provide health information. The main goal is to understand ho…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study aims to understand how patients aged 70 and older with advanced ovarian cancer tolerate PARP inhibitor medications in real-world settings. Researchers will follow 50 patients starting these drugs for the first time, tracking how much medication they can actually take v…

This study is creating and testing a Spanish-language decision aid for ovarian cancer patients. The tool is designed to help Spanish-speaking patients better understand their maintenance therapy options and participate in choosing their treatment. Researchers will test the tool w…

This study aims to see if tracking changes in a common inflammation marker (CRP) in the blood can predict how well patients with advanced gynecologic cancers respond to immunotherapy. It will involve 120 women already scheduled to receive standard immunotherapy and chemotherapy. …

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand why people react differently to cancer drugs. Researchers will collect blood or cheek swab samples from about 1,100 cancer patients already enrolled in treatment trials at the National Cancer Institute. By analyzing genes, they hope to learn which ge…

This study aims to understand how ovarian cancer is currently treated in Brazil and what outcomes patients experience. It will follow 250 patients for three years to collect information on their treatments, disease progression, and survival. The goal is to identify strengths and …

This study aims to understand how chemotherapy affects memory and thinking skills in women with advanced ovarian cancer. Researchers will follow 18 patients for about 10 months, testing their cognitive function before, during, and after treatment. The goal is to measure changes i…

This study aims to collect real-world information on how cancer patients experience and report their symptoms from home during treatment. About 25 adults with breast, lung, ovarian, or blood cancers will use an online platform to complete weekly surveys for at least 12 weeks. The…

This study is a national registry that will follow nearly 2,000 patients in Germany with advanced ovarian or endometrial cancer for up to three years. Its purpose is to document the real-world treatments patients receive, track how the disease progresses, and measure their qualit…

This study aims to find out if the bacteria and chemicals in the vagina can help detect ovarian cancer earlier. Researchers will collect one-time vaginal swab and stool samples from 50 healthy volunteers without cancer or known genetic risk. These samples will be compared to thos…

This study aims to understand why the immune system struggles to fight ovarian cancer. Researchers will collect blood, bone marrow, and tissue samples from 90 women—some with ovarian cancer and some without—to analyze their immune cells. The goal is to see if specific agents can …

This study aims to find new genetic targets for future ovarian cancer treatments. Researchers will analyze tissue samples from 180 women with ovarian cancer using computer models, lab tests, and cell experiments. The goal is to understand which genes are involved in cancer growth…

This study aims to understand how different cancers interact with the body's immune system, particularly focusing on immune cells called T cells. Researchers will collect tissue and blood samples from 1,100 patients with seven types of solid tumors over five years. The goal is to…

This study aims to discover what makes some ovarian cancer patients respond well to platinum-based chemotherapy for many years, while others stop responding quickly. Researchers will compare 55 patients from two groups: those who remained cancer-free for over 5 years after treatm…

This study aims to create better educational materials about genetic testing for cancer patients who speak different languages and come from diverse cultural backgrounds. Researchers will work with 445 patients who have breast, ovarian, prostate, pancreatic, or colorectal cancer …

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …

This study is testing whether a blood test can detect early signs that a specific ovarian cancer treatment is becoming less effective. Researchers will collect blood samples from 130 patients with BRCA-mutated ovarian cancer who are receiving standard maintenance therapy. The goa…

This study aims to understand how ovarian cancer treatments work in real-world medical practice in Germany. It will follow 750 women with newly diagnosed advanced ovarian cancer who are receiving standard chemotherapy and may get additional maintenance therapy. Researchers will t…