OVARIAN CANCER

This study looks at whether a blood test score (KELIM) can help doctors decide the best time for surgery in people with advanced ovarian cancer. After three rounds of chemotherapy, patients with a good score will have surgery sooner, while those with a poor score will get more ch…

This early-phase trial tests whether two experimental drugs, XmAb541 and XmAb808, are safe and tolerable when given together to people with advanced ovarian cancer. The study aims to find the best dose and see if the combination can shrink tumors. About 90 adults with a specific …

This study tests a drug called sacituzumab in 22 people with a rare and aggressive ovarian cancer (clear cell carcinoma) whose tumors grew after immunotherapy. The goal is to see if the drug can shrink tumors and control the disease. Participants will receive the drug and be moni…

This study tests a new drug called Rina-S, given alone or with bevacizumab, against standard platinum-based chemotherapy for people with ovarian cancer that has returned but still responds to platinum drugs. About 688 participants will be randomly assigned to receive either the n…

This early-stage study tests a new cell therapy called KT032 in 24 adults with advanced solid tumors (ovarian, mesothelioma, or colon cancer) that have spread in the belly. The main goals are to check safety and find the best dose. Participants must have tried standard treatments…

This study tests a new drug called JPI-547 combined with bevacizumab in 81 people with ovarian cancer that has come back after prior treatment with platinum chemotherapy and PARP inhibitors. The goal is to find the best dose and see if the combination can delay cancer growth. Par…

This phase 2 trial tests a combination of three drugs—liposomal irinotecan, sintilimab, and anlotinib—in 36 people with recurrent or persistent ovarian clear cell carcinoma. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have alre…

This study tests a new drug called QLS5132 given with other cancer treatments for people with advanced solid tumors, including stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination can shrink tumors. About 626 participants will…

This study tests two drug combinations (fluzoparib plus famitinib or SHR-1701) given before surgery to shrink tumors in people with advanced ovarian cancer. The goal is to make surgery possible and improve long-term outcomes. About 104 newly diagnosed patients with a specific gen…

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and Cyclophosphamide) in 40 adults with recurrent ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see if this mix can control the cancer longer and improve survival. Participants must h…

This early-stage trial tests two drugs, CKD-215 and D215, in 24 adults with advanced BRCA-mutated ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see how the body processes each drug and check for side effects. Participants will receive both drugs in a rando…

This study tests whether giving the dye Cytalux (pafolacianine) several days before surgery works as well as giving it closer to surgery to help surgeons see tumors during the operation. About 106 adults with suspected lung cancer or confirmed ovarian cancer will take part. The g…

This early-phase study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are genetically modified to better recognize and attack cancer cells,…

This study tests whether a combination of two drugs, fluzoparib and famitinib, can help keep advanced ovarian cancer from returning after initial chemotherapy. About 43 women with stage III or IV ovarian cancer who responded well to chemo will take these pills daily for up to 2 y…

This study compares two chemotherapy approaches for women with advanced ovarian cancer that has a high level of the PARK2 gene. One group gets the standard two-drug combo (paclitaxel plus carboplatin), while the other gets only paclitaxel. The goal is to see if the single drug wo…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests a new blood test (OCS) that looks for tiny particles from cancer cells (exosomes) to see if it can spot ovarian cancer returning after treatment. It is for patients whose standard CA125 test was normal before their first treatment. The goal is to find a better wa…

This study will test a new blood test that looks for DNA changes to detect ovarian cancer, especially in its early stages. Researchers will collect blood samples from 1000 women who have ovarian masses and are scheduled for surgery or biopsy. The goal is to see how well the test …

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can detect these cancers early, when they are easier to treat. About 300 women, some with ca…

This study tests whether N-Acetyl-Cysteine (NAC), a supplement, can reduce memory and thinking problems caused by chemotherapy in ovarian cancer patients. About 102 women with advanced ovarian cancer will take NAC alongside their standard platinum-based chemo. The goal is to find…

This study looks at whether hand and foot exercises can reduce nerve damage (numbness, tingling) caused by chemotherapy in older adults with gynecological cancer. About 74 people aged 65 and older will take part. The goal is to see if these exercises improve quality of life and r…

This study tests a new questionnaire (the QLQ-OV39) to see if it accurately measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to improve how doctors and rese…

This study looks back at the medical records of 600 women with advanced ovarian cancer who took PARP inhibitor drugs after initial treatment. Researchers want to see if those who ate a low-carb diet had better survival than those who ate a regular diet. No special diet is given—p…

This study looks at how consistently different labs measure a protein called FRa in ovarian cancer tissue samples. It uses archived biopsies from about 1,000 women with ovarian cancer. No new treatments or drugs are given—researchers simply compare test results from local and cen…

This study uses a special 3D ultrasound to look at blood flow inside cervical and ovarian tumors. Researchers want to see if blood flow patterns can help predict how the disease will progress. About 100 adult women with these cancers or precancerous changes will take part, along …

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from both machines using the same D…

This study tests whether artificial intelligence (AI) can accurately predict the type of ovarian cancer and how well surgery will go by analyzing videos from a diagnostic laparoscopy. Researchers will enroll 100 adults with advanced ovarian cancer to see if the AI can match the f…

This study looks at whether watching an educational video changes what people know and how they feel about genetic testing for hereditary cancers. About 200 adults who have been diagnosed with a cancer that can run in families will take a survey, watch the video, and then take an…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps patients manage follow-up care and feel more in control of their health. The goal is to see if the program is helpful and practical for use …

This study looks at whether analyzing tumor cells found in the blood can help predict how well certain cancer drugs (PARP inhibitors and chemotherapy) will work. Researchers will collect blood samples from 300 adults with advanced breast, prostate, pancreatic, or ovarian cancer. …

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 50 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help choose…