OVARIAN CANCER

This study is testing a new drug combination, JPI-547 with bevacizumab, as a maintenance therapy for women with recurrent ovarian cancer. It aims to see if this combination can help keep the cancer from progressing after patients have responded to platinum-based chemotherapy. The…

This is a very early study to test the safety and find the right dose of a new cell therapy called KT032. It is for adults with advanced ovarian cancer, mesothelioma, or colon cancer that has stopped responding to standard treatments. The therapy involves collecting and modifying…

This study is testing whether a combination of three drugs—benmelstobart, anlotinib, and cyclophosphamide—can help control recurrent ovarian, fallopian tube, or primary peritoneal cancer. It will enroll 40 participants in China who have seen their cancer return after previous tre…

This study is testing whether paclitaxel chemotherapy alone works as well as the standard paclitaxel-carboplatin combination for advanced ovarian cancer patients with high levels of a specific gene called PARK2. Researchers want to see if using just one drug can reduce side effec…

This study is testing whether taking two oral medications (fluzoparib and famitinib) as maintenance therapy can help delay the return of advanced ovarian cancer in women who responded well to their initial chemotherapy. The trial will enroll 43 women aged 18-75 who have advanced …

This study is testing an experimental drug called QLS5132, given by IV in combination with other cancer therapies, for people with advanced solid tumors like lung, stomach, ovarian, and endometrial cancer. The main goals are to find a safe and effective dose and to see how well t…

This study is testing a new combination of three drugs to see if it can shrink tumors and control a specific, hard-to-treat type of ovarian cancer that has come back or persisted after prior treatment. It will enroll 36 patients to evaluate how well the treatment works and how sa…

This study is testing an investigational pill called valemetostat for adults with advanced solid tumors that have stopped responding to standard treatments. It is specifically for people whose cancers have certain genetic changes affecting a cellular system called SWI/SNF. The go…

This study is testing a drug called sacituzumab for a specific, hard-to-treat type of ovarian cancer (clear cell carcinoma). It is for patients whose cancer has started growing again after treatment with immunotherapy. The goal is to see if this new drug can shrink tumors and con…

This study is testing two different drug combinations to shrink tumors in people with advanced ovarian cancer before they have surgery. It's for patients whose cancer can't be fully removed with initial surgery or who can't tolerate that surgery. Researchers will compare how well…

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This study is for people with recurrent ovarian cancer that has progressed after treatment with a specific type of maintenance therapy (PARP inhibitors). It aims to see if a newer, targeted drug called trastuzumab deruxtecan works better than standard chemotherapy. The drug speci…

This early-phase study is testing a new personalized treatment for adults with advanced ovarian cancer and other solid tumors that have come back or stopped responding to standard therapies. Doctors will modify a patient's own immune cells in a lab to better recognize and attack …

This study is creating and testing a patient navigation program to help young adults who have survived cancer. The program aims to guide survivors to get the recommended primary care and cancer check-ups they need. Researchers will first adapt an existing program for young surviv…

This international study aims to improve treatment for advanced ovarian cancer by personalizing the timing of surgery. Patients first receive three cycles of chemotherapy. A special blood test score (KELIM) then determines their next steps: patients with a good score have surgery…

This study is testing whether artificial intelligence (AI) can analyze videos taken during a diagnostic laparoscopy procedure to help doctors make better decisions for ovarian cancer patients. The AI aims to predict the specific type of ovarian cancer and whether surgeons will li…

This study is testing a new, more comfortable device for collecting vaginal samples to see if it can help detect ovarian and endometrial cancers earlier. Researchers will collect samples from 300 women, including some with cancer and some without, to look for biological markers l…

This study aims to see if giving a special fluorescent dye called Cytalux several days before surgery works as well as giving it just hours before. The dye helps surgeons see cancer tissue during operations for lung or ovarian cancer. Researchers will compare the two timing windo…

This study is testing a new blood test called OCS, which looks for tiny particles called exosomes, to see if it can detect when ovarian cancer comes back. It focuses on patients whose standard blood marker (CA125) was low when they were first diagnosed. The goal is to find a more…

This study is testing whether adding the supplement N-Acetyl-Cysteine (NAC) to standard platinum-based chemotherapy can help reduce memory and thinking problems, often called 'chemo brain,' in women with ovarian cancer. The first part of the study will find the safest dose of NAC…

This study is testing whether a simple hand and foot exercise program can help reduce nerve pain and improve quality of life for older women receiving chemotherapy for gynecologic cancers. Researchers will enroll 74 participants aged 65+ who are experiencing nerve pain from their…

This study aims to understand if measuring blood flow to tumors can help predict how cervical and ovarian cancers behave. Researchers will use a special 3D ultrasound scan on 100 women with these cancers or precancerous changes. The goal is to see if blood flow patterns are linke…

This study aims to see if watching an educational video improves cancer patients' understanding of genetic testing and helps them make informed choices about whether to pursue it. Researchers will enroll 200 patients with cancers that can have hereditary forms. Participants will …

This study compares two different DNA sequencing machines to see if they give similar results for genetic testing in cancer patients. Researchers will test the same patient samples on both the new MGI machine and the established Illumina machines. The goal is to determine if the …

This study aims to test and improve a questionnaire designed to measure quality of life for ovarian cancer patients. Researchers will ask 50 patients with ovarian cancer to complete the questionnaire and provide feedback through interviews. The goal is to create a better tool for…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study aims to understand whether surgeons can accurately identify specific features of advanced ovarian cancer just by looking at it during surgery. Researchers will ask 70-80 experienced ovarian cancer surgeons to review laparoscopic images from 19 patients and describe wha…

This study looks back at medical records to see if eating a low-carbohydrate diet is linked to better survival for women with a specific type of ovarian cancer who are on a standard maintenance therapy. Researchers will compare the outcomes of about 600 patients who had different…