New hope for advanced cancers? AZD8205 trial launches

NCT ID NCT05123482

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated Jun 19, 2026 · Updated 37 times

Summary

This study tests a new drug called AZD8205, alone or with other cancer drugs, in people with advanced solid tumors like breast, ovarian, lung, or bile duct cancer that have spread or come back. About 460 adults will take part to find safe doses and see if the drug shrinks tumors. The goal is to control the disease, not cure it, and participants will be closely monitored for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Research Site
COMPLETED

Duarte, California, 91010, United States
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COMPLETED

Irvine, California, 92618, United States
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RECRUITING

Santa Monica, California, 90404, United States
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Santa Rosa, California, 95403, United States
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COMPLETED

Shreveport, Louisiana, 71103, United States
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Baltimore, Maryland, 21231, United States
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Boston, Massachusetts, 02215, United States
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St Louis, Missouri, 63110, United States
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Albuquerque, New Mexico, 87109, United States
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Commack, New York, 11725, United States
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WITHDRAWN

New York, New York, 10029, United States
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Charlotte, North Carolina, 28204, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Houston, Texas, 77030, United States
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TERMINATED

Clayton, 3168, Australia
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Melbourne, VIC 3000, Australia
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Nedlands, 6009, Australia
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Anderlecht, 1070, Belgium
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Leuven, 3000, Belgium
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Calgary, Alberta, T2N 5G2, Canada
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Vancouver, British Columbia, V5Z 4E6, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Beijing, 100142, China
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Beijing, 100142, China
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TERMINATED

Changsha, 410013, China
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Changsha, 410013, China
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Chongqing, 400030, China
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Guangzhou, 510060, China
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Kunming, 650118, China
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Shandong, China
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Budapest, 1062, Hungary
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Budapest, 1082, Hungary
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Budapest, 1122, Hungary
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Milan, 20141, Italy
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Milan, 20159, Italy
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Modena, 41125, Italy
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Roma, 00168, Italy
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Chūōku, 104-0045, Japan
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Hidaka-shi, 350-1298, Japan
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Kashiwa, 277-8577, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Sunto-gun, 411-8777, Japan
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Amsterdam, 1066 CX, Netherlands
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Gdansk, 80-214, Poland
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Warsaw, 02-781, Poland
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Barcelona, 8035, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28027, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11259, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10330, Thailand
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Chiang Mai, 50200, Thailand
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Cambridge, CB2 0XY, United Kingdom
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COMPLETED

Cardiff, CF14 2TL, United Kingdom
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London, EC1A 7BE, United Kingdom

Conditions

The condition(s) this trial relates to.

bile duct carcinoma biliary tract cancer breast cancer breast neoplasm endometrial cancer endometrium neoplasm neoplasm non-small cell squamous lung carcinoma ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT CARCINOMA BREAST CANCER ENDOMETRIAL CANCER ENDOMETRIAL CANCER OVARIAN CANCER SQUAMOUS NON-SMALL-CELL LUNG CANCER