Astrazeneca

This study is testing an injectable medication called tezepelumab in children aged 5 to 12 with severe asthma that is not well-controlled by their current inhalers and medications. Over 200 children will receive either the real drug or a placebo injection every few weeks for a ye…

This study is testing whether adding a new intravenous drug (Dato-DXd) to an existing pill (osimertinib) works better than the pill alone for people with a specific type of advanced lung cancer. It will involve about 582 adults who have not yet received treatment for their advanc…

This early-stage study is testing the safety of a new cell therapy called AZD0120 for adults with severe autoimmune diseases like systemic sclerosis, inflammatory muscle disease, or hard-to-treat rheumatoid arthritis. Doctors will collect a patient's own immune cells, modify them…

This study is testing two new immune-boosting drugs, called volrustomig and rilvegostomig, for people with advanced liver or bile duct cancer. The drugs will be given alone or combined with standard chemotherapy to see if they can shrink tumors and control the disease. The goal i…

This study is testing two drugs, saruparib and darolutamide, in men newly diagnosed with prostate cancer who are scheduled for surgery to remove the prostate. The goal is to see how these drugs, given alone or together for a short time before surgery, affect the cancer cells in t…

This study is testing whether a new drug called AZD2373 can help people with APOL1-mediated kidney disease, a genetic condition that damages the kidneys. About 96 participants with specific genetic markers will receive either the drug or a placebo for at least 30 weeks. Researche…

This study is testing whether a new oral drug called AZD0780, when taken alongside the common cholesterol medication rosuvastatin, can lower 'bad' LDL cholesterol more effectively than rosuvastatin alone. It will involve about 76 adult participants in Russia who have high cholest…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific KRAS gene mutation. Doctors will collect a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cells with t…

This study is testing a drug called benralizumab in children aged 6 to 18 with rare diseases where a type of white blood cell (eosinophils) causes inflammation and organ damage. The main goal is to see if the drug is safe and effective at controlling disease flares and reducing t…

This study is testing a new drug called AZD0901, both by itself and combined with chemotherapy, for people with advanced cancers of the stomach, pancreas, and bile ducts. The main goals are to see if the treatment is safe and if it can shrink tumors. It is for adults whose cancer…

This study is testing if Nexium (esomeprazole) can safely keep erosive esophagitis healed in children aged 1 to 11. Erosive esophagitis is damage to the food pipe caused by stomach acid. Researchers will compare two doses of the medication over 16 weeks to see which works better …

This study aims to see if a standardized care program can help doctors better manage high potassium levels in patients with chronic kidney disease. About 1,000 adult patients in China will follow a specific management plan, including education, regular blood tests, and medication…

This study is observing how well the drug T-DXd works for people with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients in real-world US clinics to see how their tumors respond and how long the …

This study is testing whether a new oral drug called camizestrant works better than standard hormone therapy at preventing breast cancer from returning. It's for people with early-stage, hormone-sensitive breast cancer who have a medium or high risk of the cancer coming back, and…

This study is testing the safety and initial effectiveness of a combination treatment for people with advanced non-small cell lung cancer that has a specific marker called HER2. The treatment combines a targeted drug (trastuzumab deruxtecan) with different immunotherapy drugs, so…

This is a first-in-human study testing a new radioactive drug called [225Ac]-FPI-2068 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose, see how the drug travels in the body, and check for early signs …

This study aims to understand how effective and safe two existing cancer drugs, sunitinib and sorafenib, are for Chinese adults with advanced papillary kidney cancer that cannot be surgically removed. Researchers will look back at the medical records of about 150 patients who rec…

This study is testing an investigational drug called tozorakimab to see if it can help adults who are hospitalized with a severe viral lung infection and need extra oxygen. The main goal is to see if the drug, given along with standard hospital care, can prevent patients from dyi…

This study follows 200 adults with systemic lupus erythematosus (SLE) who are prescribed anifrolumab as part of their regular treatment. Researchers will observe how well the medication controls lupus symptoms and improves quality of life over one year in real-world clinical sett…

This study is testing if combining two drugs, baxdrostat and dapagliflozin, works better than baxdrostat alone to reduce protein in the urine (a sign of kidney damage) in people with chronic kidney disease and high blood pressure. About 218 adults with these conditions will be ra…

This study is observing 300 men in France who are already taking the drug olaparib for advanced prostate cancer that has spread and stopped responding to hormone therapy. The goal is to see how long patients stay on the treatment in real-world clinics, monitor side effects, and l…

This early-stage study is testing a new oral medication called AZD0780 to see if it safely lowers LDL (bad) cholesterol. The trial involves 40 healthy adults who already have elevated cholesterol levels. Participants will take either the experimental drug or a placebo daily for 2…

This early-stage trial is testing a new drug called AZD5863 in adults with advanced stomach, esophageal junction, or pancreatic cancers that have spread. The drug is designed to help the body's own immune cells find and attack cancer cells. The main goals are to find a safe dose …

This study is testing whether anifrolumab, given as an injection under the skin, can safely reduce severe skin rashes in adults with cutaneous lupus. Participants have rashes that haven't improved enough with standard antimalarial pills. The main goal is to see if the drug can si…

This study is testing whether a new two-drug combination works better than current standard treatments for advanced breast cancer that has specific genetic mutations. About 500 adults with advanced breast cancer that has spread or can't be cured with surgery will participate. The…

This is the first study to give the experimental drug AZD1390 to people. It aims to find a safe dose of AZD1390 when given alongside standard radiation therapy to patients with aggressive brain tumors, including glioblastoma and cancer that has spread to the brain. The main goal …

This study looks at how two different rescue inhalers work for adults with asthma in their everyday lives. Researchers will compare Airsupra and the commonly used albuterol in 4,000 people across the United States. The main goal is to see which medication better reduces the risk …

This early-stage study is testing a new drug called AZD0516 for men with advanced prostate cancer that has spread. Researchers want to find a safe dose and see if the drug, given alone or with other cancer treatments, can help control the disease. The study will enroll about 177 …

This large study is testing whether adding an experimental drug called saruparib to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has spread but still responds to hormone treatment. About 1,800 participants will be randomly assigne…

This large, global study aims to see if a new drug combination (AZD0486 plus rituximab) works better and is safer than standard chemotherapy for people newly diagnosed with follicular lymphoma, a type of blood cancer. Over 1,000 participants will be randomly assigned to receive e…

This large, late-stage trial is testing whether a new drug called AZD5335 works better than current standard treatments for women with advanced ovarian cancer that has stopped responding to platinum chemotherapy. About 1100 participants will be assigned to receive either the new …

This study is testing anifrolumab, an intravenous medication, in children aged 5 to 17 with moderate to severe lupus. Participants will receive either the drug or a placebo while continuing their standard lupus treatments. The main goals are to see how the drug behaves in childre…

This study follows 250 men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. Researchers will observe how long patients continue taking the combination of two medications (olaparib and abiraterone) in real-world medical settings. Th…

This study aims to understand the safety of the drug trastuzumab deruxtecan specifically for Indian patients with advanced HER2-positive breast cancer that has spread and cannot be surgically removed. It will involve 100 adult patients who have already received at least one prior…

This study is testing whether a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler when used as needed to prevent severe asthma attacks. It involves 440 teenagers aged 12-18 who have asthma and have had at least one serious attack in the pas…

This study is testing whether adding a new drug called zibotentan to an existing kidney drug (dapagliflozin) works better than dapagliflozin alone. It aims to see if the combination can better reduce the amount of protein leaking into the urine, which is a sign of kidney damage. …

This study is testing whether adding a new drug called capivasertib to two standard breast cancer drugs works better for controlling advanced breast cancer. It will involve about 895 adults whose cancer is hormone receptor-positive, HER2-negative, and has worsened despite prior h…

This large global study is comparing two different immunotherapy drugs (rilvegostomig and durvalumab) when combined with standard chemotherapy for people with advanced bile duct cancer who haven't had previous treatment. The main goal is to see which combination helps patients li…

This study is testing whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder removal surgery helps control muscle-invasive bladder cancer better. The research involves 150 patients worldwide who are scheduled for bladder removal surgery…

This is a first-in-human study testing a new radioactive drug called AZD2284 in men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The main goal is to find a safe and tolerable dose. Researchers will also use imaging to see how t…

This study is testing several new drug combinations for people with advanced or metastatic non-small cell lung cancer. Researchers want to find safe doses and see if these combinations can shrink tumors and help patients live longer. The trial will involve 152 participants and in…

This study is testing whether adding the drug acalabrutinib to standard R-CHOP chemotherapy works better for people newly diagnosed with mantle cell lymphoma. The trial will enroll about 55 adults in Spain who haven't had prior cancer treatments and aren't candidates for stem cel…

This large study aims to see if a three-drug inhaler is better than a two-drug inhaler at preventing serious heart and lung problems in people with COPD who are at higher risk for these events. It will involve about 5,000 adults with COPD and certain heart disease risk factors. P…

This study is testing an experimental drug called trastuzumab deruxtecan (T-DXd), either alone or combined with other cancer drugs, for people with advanced solid tumors that have a specific marker called HER2. The goal is to see if the treatment can shrink tumors and control the…

This study is testing whether an experimental drug called AZD4144 can help improve kidney function in hospitalized adults whose kidneys have been injured by a severe bloodstream infection (sepsis). About 124 participants will be randomly assigned to receive either the drug or a p…

This study is testing several new combinations of immunotherapy and chemotherapy drugs for people with early-stage, operable lung cancer. The goal is to see if giving these drugs before surgery (to shrink the tumor) and after surgery (to prevent the cancer from coming back) is sa…

This study aims to understand how well the lung cancer drug osimertinib works for patients in real-world Spanish hospitals, outside of controlled clinical trials. It will follow 500 adults with a specific genetic type of non-small cell lung cancer who are already being treated wi…

This early-stage study aims to find a safe and effective dose of a new drug called AZD6750, which is designed to boost the immune system to fight cancer. It will test the drug alone and combined with other cancer treatments in about 60 adults with advanced or spreading solid tumo…

This is the first study in people to test a new drug called surovatamig for rheumatoid arthritis and lupus. The main goal is to check its safety and how the body processes it in 48 adults with these conditions. Researchers will give the drug as an injection under the skin at diff…

This study is testing a new drug called AZD0901 for people with advanced stomach or gastroesophageal cancer that has spread and stopped responding to initial treatments. It compares AZD0901 to the doctor's choice of standard therapies to see which works better at controlling the …

This study aims to see how well the drug tezepelumab works for adults with chronic nasal polyps, with or without asthma, in real-world medical settings. It will follow 110 participants in Russia for about a year to measure changes in their nasal symptoms, asthma control, and over…

This study is testing an investigational antibody drug called AZD0292 to see if it can prevent serious lung flare-ups in people with bronchiectasis who have a chronic infection with a bacteria called Pseudomonas aeruginosa. Researchers will compare the drug against a placebo in a…

This study is testing whether two new drug combinations work better than the current standard treatment for advanced bile duct cancer. It will enroll about 620 adults with a specific protein marker (HER2) on their cancer cells who haven't had prior treatment for their advanced di…

This study aims to understand how well the asthma medication benralizumab works for people with severe eosinophilic asthma in everyday clinical practice in China. Researchers will follow 1,000 patients aged 12 and older to see how their asthma control and lung function change ove…

This study is testing if adding a new drug called Saruparib to standard radiation and hormone therapy can better prevent cancer from spreading in men with high-risk prostate cancer who have a specific genetic mutation (BRCA). About 700 men will be randomly assigned to receive eit…

This study is testing several new combinations of cancer drugs for people with advanced non-small cell lung cancer that has spread. The main goals are to see if these combinations are safe and if they can shrink tumors. The trial will involve about 278 patients across 80 medical …

This early-stage trial is testing a new drug called AZD8205, both by itself and combined with other cancer drugs, for people with advanced solid tumors that have spread or returned. The main goals are to find safe doses and see if the treatments can shrink tumors. It is enrolling…

This study is testing a new drug called AZD5492 for adults whose B-cell cancers have come back or stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug helps control the cancer. The drug works by directing the patient's own immune T…

This study is testing if a new treatment plan is better for older or frail adults with a type of blood cancer called large B-cell lymphoma. It compares a shorter course of standard chemotherapy followed by a new drug (AZD0486) against a longer course of standard chemotherapy alon…

This study is testing a new drug called volrustomig, both by itself and combined with chemotherapy, for people with advanced solid tumors that have spread. It is enrolling about 257 adults with specific advanced cancers, including cervical, head and neck, esophageal, and a type o…

This study aims to see how well the approved biologic drug benralizumab works for people with severe asthma in their everyday lives, outside of a controlled clinical trial. It will follow 300 patients in Germany for a year, tracking their asthma symptoms, quality of life, lung fu…

This study is observing patients in Korea who are already taking Koselugo for neurofibromatosis type 1 (NF1) and its associated nerve tumors. Its main purpose is to monitor the drug's safety and see how well it works in everyday medical practice, outside of a controlled clinical …

This study compares new targeted drug combinations against standard chemotherapy for advanced or returning endometrial cancer. It will enroll 600 adults with specific tumor characteristics to see which approach better controls cancer growth and extends survival. Researchers are t…

This study is testing the safety and effectiveness of the immunotherapy drug durvalumab for people in Spain with a specific, aggressive type of lung cancer called limited-stage small cell lung cancer. The drug is given after patients have completed standard chemotherapy and radia…

This early-stage study is testing a new oral drug called AZD3632 for people with advanced blood cancers like leukemia and myelodysplastic syndromes that have returned or stopped responding to standard treatments. The main goals are to find a safe dose, see how the body processes …

This study is testing whether a leukemia drug called acalabrutinib is safe for people who also have moderate to severe heart problems. Researchers will compare it to other standard treatments to see which causes fewer heart-related side effects. The trial will enroll 60 adults wi…

This study follows 1,400 adults with moderate to severe COPD who are starting treatment with Breztri/Trixeo, a triple-therapy inhaler. Researchers will track how patients feel and function over 12 months in real-world medical settings across Latin America, Asia, and the Middle Ea…

This large international study is testing whether new drug combinations work better than current standard treatments for advanced triple-negative breast cancer. Researchers will compare two experimental treatments against standard chemotherapy in 625 patients whose cancer has ret…

This study is for people with a specific type of advanced lung cancer (EGFR-mutated NSCLC) whose disease has gotten worse while taking the drug osimertinib. It will test whether a new drug called Dato-DXd, given alone or together with osimertinib, works better and is safer than s…

This study aims to collect real-world information on how well a specific combination of cancer drugs works for women with advanced or recurrent endometrial (uterine) cancer in Germany. It will follow 150 patients who are already receiving this standard treatment in their regular …

This study is testing two new investigational drugs, AZD6234 and AZD9550, to see if they are safe and can help with weight loss in Chinese adults who have obesity or are overweight. Researchers will give the drugs separately and together to about 871 participants to compare their…

This study aims to monitor the safety and real-world effectiveness of two approved cancer drugs, durvalumab and olaparib, in patients with endometrial cancer in Korea. It will follow about 50 patients for up to a year after they start treatment as part of their normal medical car…

This global Phase 3 trial is testing whether a new drug called rilvegostomig works better than the current standard treatment when combined with chemotherapy for advanced squamous lung cancer. The study will involve about 880 patients whose cancer has spread and who haven't recei…

This study aims to monitor the safety of a drug called Ondexxya, which is used in emergencies to reverse the effects of certain blood thinners in patients with life-threatening bleeding. It will enroll 300 patients who received the drug in real-world hospital settings. The main g…

This is the first study in people to test the safety of an experimental drug called AZD4248. Researchers will give single and multiple doses to healthy volunteers and people with diabetic kidney disease to see how the body handles it and check for side effects. A separate part of…

This study monitors the safety and effectiveness of the already-approved breast cancer drug Capivasertib as it is used in everyday medical practice in South Korea. It aims to track any side effects and see how well the drug works for about 130 patients who are prescribed it accor…

This study is testing a new oral medication called AZD0780 to see if it can safely and effectively lower 'bad' cholesterol (LDL-C) in people with dyslipidemia. The trial will involve about 360 adults in China, some already on standard cholesterol treatments and some not. Particip…

This study is testing several new drug combinations given before and after surgery for people with advanced but removable stomach or esophageal cancer. The main goals are to see if these treatments are safe and if they can shrink or eliminate the tumor before it is surgically rem…

This early-stage study is testing a new drug called AZD3470 in people with advanced solid tumors that have a specific genetic flaw called MTAP deficiency. The main goals are to find a safe dose and see if the drug, given alone or with other cancer treatments, can help control the…

This study is testing if a new combination of two immunotherapy drugs (durvalumab and tremelimumab) plus chemotherapy helps people with advanced non-small cell lung cancer live longer than the current standard treatment (pembrolizumab plus chemotherapy). It is specifically for pa…

This study is testing whether a new drug called volrustomig, when given alongside standard chemotherapy, is safe and can help control advanced non-small cell lung cancer. It will involve about 180 people whose cancer has spread and who have not yet received treatment for the adva…

This study is testing an investigational drug called Dato-DXd for people with a specific type of advanced breast cancer that has spread and no longer responds to standard hormone treatments. The goal is to see if this drug, given as an IV infusion every 3 weeks, can effectively c…

This study is testing whether people with severe asthma who start taking the biologic drug tezepelumab can safely reduce or stop some of their other daily controller medications. It will enroll about 400 patients in China and follow them for a year. The main goal is to see if pat…

This study monitors the safety and effectiveness of two already-approved liver cancer drugs (Imjudo and Imfinzi) in real-world medical practice in Korea. It will follow 246 patients who are receiving these drugs as part of their standard cancer treatment. The goal is to collect i…

This study is testing a new experimental drug called AZD9793 in adults with advanced liver cancer that has spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the treatment can shrink tumors. Researchers will give the drug to about 304 partic…

This study is testing a combination of two drugs, acalabrutinib and rituximab, for older or frail adults newly diagnosed with an aggressive type of lymphoma called DLBCL. The goal is to see if this treatment is safe and effective for patients who are too weak for standard, more i…

This large, late-stage study aims to find out if a new two-in-one pill (balcinrenone/dapagliflozin) works better than a current standard drug (dapagliflozin) to prevent hospital visits and death from heart failure. It will involve about 4,800 adults worldwide who have both chroni…

This study is testing whether adding a new immunotherapy drug (volrustomig) to standard chemotherapy works better for people with advanced colorectal cancer that hasn't spread to the liver. The trial will compare the safety and effectiveness of the new combination against standar…

This study is testing whether an investigational drug called volrustomig can help prevent cancer from returning in women with high-risk, locally advanced cervical cancer who have completed initial chemoradiation treatment. About 800 participants will be randomly assigned to recei…

This large Phase 3 study is testing whether adding new targeted drugs to standard chemotherapy works better for people with advanced stomach, esophageal, or gastroesophageal junction cancers. The trial is specifically for patients whose cancers test positive for a protein called …

This is a first-in-human study testing a new personalized cell therapy called NT-175. It is for adults with advanced solid cancers (like lung, colorectal, or breast cancer) that have spread and have a specific genetic mutation (TP53 R175H). The main goals are to find a safe dose …

This global Phase 3 trial is testing whether a new drug called rilvegostomig works better than the standard drug pembrolizumab when both are combined with chemotherapy. It's for people with advanced non-small cell lung cancer that has spread and expresses a specific marker (PD-L1…

This study is testing whether an existing cancer drug called T-DXd can help treat many different advanced cancers that have a specific protein marker called HER2. It will enroll about 468 adults with cancers like bladder, ovarian, pancreatic, and cervical cancer that have spread …

This study is testing whether adding a new drug called domvanalimab to an existing immunotherapy (durvalumab) works better than durvalumab alone for people with advanced, inoperable lung cancer. The goal is to help control the cancer and prevent it from growing or spreading after…

This early-stage study is testing a new personalized cell therapy called AZD0120 for adults with multiple sclerosis (MS) that has not responded well to other high-efficacy treatments. The main goal is to check the safety and side effects of the treatment and to find the best dose…

This study is testing an experimental drug called surovatamig for adults whose B-cell non-Hodgkin lymphoma has come back or stopped responding to at least two prior treatments. The main goals are to see if the drug can shrink the cancer and how safe it is for patients. Researcher…

This study is testing several new combinations of cancer drugs for people with advanced stomach or gastroesophageal cancer that cannot be removed by surgery. The goal is to see if these combinations can shrink tumors, delay cancer growth, and are safe for patients. The trial is f…

This study looks back at data from real-world patients with moderate to severe COPD who started a triple-combination inhaler (BGF). It aims to see how their symptoms, quality of life, and number of flare-ups change over 12 months compared to before starting the treatment. The goa…

This study is testing whether a monthly injection called tezepelumab can help control Chronic Obstructive Pulmonary Disease (COPD). It aims to reduce the frequency of serious breathing flare-ups and improve lung function and quality of life for adults with moderate to very severe…

This early-stage study is testing a new drug called AZD4360 in adults with advanced cancers of the stomach, pancreas, and related areas. The main goals are to find a safe dose and see if the drug shows any signs of helping to control the cancer. The drug is designed to target a s…

This large Phase 3 trial is testing whether a new combination of cancer drugs works better than current standard treatment for advanced HER2-positive stomach cancer. The study will enroll 840 patients with previously untreated, advanced stomach or gastroesophageal junction cancer…

This large Phase 3 trial is testing whether adding a new drug called baxdrostat to an existing diabetes medication (dapagliflozin) can better prevent heart failure and heart-related death in people with type 2 diabetes who are at high risk. The study will enroll about 11,300 part…

This study is observing how well the drug anifrolumab works for people with systemic lupus in real-world Italian clinics. It aims to see if patients can achieve a state of very low disease activity while also reducing their daily steroid dose to 5mg or less. The study will follow…

This study is testing a new oral medication, AZD6793, to see if it can reduce the frequency and severity of symptom flare-ups (exacerbations) in people with moderate to very severe COPD. About 1160 participants will be randomly assigned to receive one of three different doses of …

This early-stage study is testing a new way to give the cancer drug rilvegostomig—as a simple injection under the skin instead of through an IV. It aims to find the right injection dose that gives similar drug levels in the body as the IV method and to check its safety. The study…

This study is testing whether adding a new injectable drug, anifrolumab, to standard treatment can better control disease activity in adults with polymyositis or dermatomyositis. It will involve about 240 participants who will receive either the drug or a placebo injection for a …

This study is testing a new drug called AZD0305 for people with multiple myeloma, a type of blood cancer, that has come back or stopped responding to at least three prior treatments. The main goals are to find a safe dose and see if the drug can help control the cancer, either by…

This study is testing whether new drug combinations work better than the current standard treatment for advanced non-small cell lung cancer. It will involve 675 people with a specific type of lung cancer that has spread and has high levels of a protein called PD-L1. Participants …

This early-stage study is testing a new experimental drug called AZD6621 for men with metastatic prostate cancer that has stopped responding to standard treatments. The research will first find safe dose levels in a small group, then test those doses in more participants to see i…

This study is testing a new, experimental cancer drug called AZD5335 to see if it is safe and if it can help control advanced cancers. It will be given alone and in combination with other cancer drugs to adults with ovarian, lung, or endometrial cancers that have progressed despi…

This early-stage study is testing a new antibody drug called AZD0486 in people with B-cell non-Hodgkin lymphoma that has returned or stopped responding to previous treatments. Researchers will give increasing doses to about 317 participants to find the safest amount and check for…

This early-stage study is testing a new drug called AZD0486, both alone and combined with other cancer treatments, for people with advanced B-cell blood cancers that have returned or stopped responding to prior therapies. It aims to find a safe dose and see if the drug can shrink…

This study aims to see how well the drug anifrolumab works for controlling lupus in real-world medical practice in Poland. It will follow 100 adult patients with lupus who are already receiving this medication through a national program for about 30 months. The main goal is to me…

This study is testing a new drug called AZD4512 for people with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or hasn't responded to other treatments. The main goals are to find a safe dose and see if the drug can help patients achieve remission. The study will e…

This study is testing if a drug called sodium zirconium cyclosilicate (SZC), which is already used in adults, is safe and effective for treating high potassium levels in children. About 140 children under 18 will receive the drug, starting with older kids and moving to younger on…

This study is observing how well a drug called durvalumab works to help control limited stage small-cell lung cancer after patients finish standard chemoradiation treatment. It will follow 200 patients in China who have not gotten worse after their initial treatment. The goal is …

This study aims to see if the biologic drug benralizumab can help people with severe eosinophilic asthma achieve and maintain clinical remission. It will follow 335 adult patients in Italy for up to two years to track their symptoms, lung function, and need for other medications.…

This early-stage study is testing a new oral medication called AZD2962 for people with certain blood cancers that have returned or stopped responding to standard treatments. The main goal is to find a safe dose and see how the body handles the drug, while also looking for early s…

This study is for people with a specific type of severe asthma (eosinophilic asthma) that isn't well-controlled on their current medium-dose inhaler. It compares two approaches: adding a new injectable medication (benralizumab) versus increasing the dose of the standard steroid i…

This study is testing an investigational medicine called tozorakimab, given as an injection under the skin, for adults whose asthma is not well-controlled even with standard high-dose inhalers. The main goal is to see if different doses of tozorakimab can safely reduce the number…

This large, late-stage study aims to see if a new immunotherapy drug called rilvegostomig works better than the current standard treatment (pembrolizumab) for people with advanced non-small cell lung cancer. It will enroll about 830 participants worldwide who have not yet receive…

This Phase 3 study is testing whether an investigational drug called baxdrostat can safely lower blood pressure and correct hormone imbalances in adults with primary aldosteronism, a condition where the adrenal glands produce too much aldosterone. Approximately 180 participants w…

This study is testing an experimental drug called AZD7798 to see if it is safe and can help heal the inflamed gut lining in people with active Crohn's disease. It will involve about 30 participants who have an ileostomy, allowing doctors to directly see the drug's effects. For th…

This study aims to monitor the safety and effectiveness of the asthma medication FASENRA in children aged 6 to 15 years. It will observe about 40 children with severe asthma who are starting FASENRA for the first time in real-world, everyday use. The main goal is to check for any…

This study is testing whether a combination inhaler (budesonide-albuterol) works better than a standard albuterol inhaler at preventing severe asthma attacks when used as needed. About 790 Chinese adults with symptomatic asthma who've had at least one severe attack in the past ye…

This large, late-stage trial is testing new drug combinations for people with advanced liver cancer that cannot be cured with surgery. It will compare two experimental combinations against a current standard treatment to see which helps patients live longer and control their canc…

This large, late-stage study is testing whether a new oral drug called AZD0780 can prevent serious heart-related events like heart attacks, strokes, and death. It will involve over 15,000 adults who either already have heart disease or are at high risk for developing it. Particip…

This large, global study is testing whether a new drug called volrustomig can help keep cancer from growing or spreading in people with advanced head and neck cancer who have just finished a standard course of chemotherapy and radiation. The trial will compare the drug to simply …

This Phase 3 trial is testing whether a new, advanced cell therapy called AZD0120 works better than current standard drug combinations for people with multiple myeloma that has come back after treatment. The therapy involves modifying a patient's own immune cells to attack two sp…

This study is testing whether a triple-combination inhaler (BGF) improves how well the heart and lungs work in people with COPD who have hyperinflated lungs. About 56 participants will try both the real inhaler and a placebo inhaler for short periods in a random order. The main g…

This study is observing how well the drug ravulizumab helps adults in Poland with generalized myasthenia gravis (gMG), a disease that causes severe muscle weakness. Researchers will follow 50 patients for about 3 years to see if the treatment improves their ability to perform dai…

This study is testing whether a targeted cancer drug called T-DXd works better alone or when combined with chemotherapy and/or immunotherapy for advanced stomach and esophageal cancers that have a specific marker called HER2. It will involve about 450 adults with advanced cancer …

This early-stage study aims to test the safety and basic effects of a new experimental drug called AZD5492 in adults with lupus, inflammatory muscle diseases, or rheumatoid arthritis. Researchers will give participants one or two doses and closely monitor them for side effects an…

This study is testing a new cell therapy called AZD0120 for adults with severe systemic lupus that hasn't responded well to other treatments. The therapy involves modifying a patient's own immune cells to target and remove harmful cells that drive lupus. The first part of the stu…

This study is testing a new oral drug called AZD9574, both by itself and combined with other cancer therapies, in people with advanced solid tumors that have progressed. The main goals are to find safe doses and see early signs of whether the drug helps control the cancer. It wil…

This large global study is testing whether adding an experimental drug called volrustomig to standard chemotherapy works better than current standard treatments for advanced pleural mesothelioma, a serious cancer often linked to asbestos exposure. About 825 adults with mesothelio…

This study is testing if a monthly injection called tezepelumab can help adults with moderate to very severe COPD. The main goal is to see if it reduces the number of times a person's breathing suddenly gets much worse (called an exacerbation or flare-up). About 990 participants …

This study is testing an experimental drug called AZD0901 for people with advanced stomach or gastroesophageal junction cancer that has spread and expresses a specific protein called CLDN18.2. It is for adults whose cancer has continued to grow after at least one prior treatment.…

This study is testing an injectable medication called benralizumab in children and teenagers with a severe type of asthma. The goal is to see if it can safely reduce the number of serious asthma attacks (exacerbations) and improve daily symptoms. About 200 participants, aged 6 to…

This study is testing an experimental drug called AZD0486 for adolescents and adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or hasn't responded to at least two prior treatments. The main goals are to find a safe and effective dose and to see if the dr…

This study is testing whether a new targeted drug called datopotamab deruxtecan works better than the standard chemotherapy (docetaxel) for people with advanced non-squamous lung cancer that has worsened after initial treatment. It will enroll 400 participants whose cancer tests …

This is a first-in-human study to test the safety and how the body processes an experimental drug called AZD4063. It involves 31 adults with a specific genetic mutation that causes dilated cardiomyopathy, a condition where the heart muscle becomes weak. Participants will receive …

This large, late-stage study is testing whether adding a new drug called baxdrostat to an existing kidney-protective medicine (dapagliflozin) works better than the existing medicine alone. It aims to see if the combination can more effectively slow kidney damage, prevent kidney f…

This is the first study in humans testing a new cancer drug called AZD9592. Researchers want to find safe doses and see if it helps control advanced cancers like lung, head/neck, and colorectal tumors. The study will test AZD9592 alone and combined with other cancer treatments in…

This study is testing a new treatment called AZD0754 for men whose prostate cancer has spread and is no longer responding to standard therapies. Doctors take a patient's own immune cells, modify them in a lab to target a protein on cancer cells, and then infuse them back into the…

This is the first study in people to test a new drug called AZD8421. It aims to find a safe dose and see if it can help control advanced breast cancer or ovarian cancer that has spread and stopped responding to standard treatments. The study will test AZD8421 by itself and combin…

This early-stage study is testing the safety and initial effects of a new cell therapy called AZD0120 in adults with multiple myeloma. The therapy involves modifying a patient's own immune cells to attack two targets on the cancer cells (BCMA and CD19). The main goal is to see ho…

This study is testing a new drug called AZD1163 for people with moderate-to-severe rheumatoid arthritis (RA). It aims to see if the drug can safely reduce disease activity and inflammation when added to a person's current standard medications. About 320 participants will receive …

This large, late-stage trial is testing whether a new targeted drug called puxitatug samrotecan helps people with advanced endometrial cancer live longer or live longer without their cancer getting worse, compared to standard chemotherapy. It is for people whose cancer has contin…

This study is testing a combination of three medicines—durvalumab, tremelimumab, and lenvatinib—as the first treatment for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if this three-drug approach can better control the cancer's growth an…

This study is testing a new drug called AZD4512 for adults with B-cell non-Hodgkin lymphoma that has come back or stopped responding to at least two prior treatments. The main goals are to find a safe dose and see if the drug helps control the cancer. It will involve about 91 par…

This is an early safety study for a new drug called AZD1613, designed for people with autosomal dominant polycystic kidney disease (ADPKD). The main goal is to see if the drug is safe and well-tolerated when given as an injection or through an IV, and to understand how the body p…

This study is testing a new lung cancer screening program for current and former smokers. It will enroll 1000 people to get yearly low-dose CT scans and blood tests to see if cancer can be found earlier. The goal is to see if this screening approach works well in a public health …

This study aims to see if two new, easier-to-perform breathing tests can help primary care doctors accurately diagnose asthma and COPD. It will involve 600 adults with symptoms but no prior diagnosis. The goal is to compare the accuracy of these new tests performed in a regular d…

This study is testing a new artificial intelligence (AI) tool designed to help identify women at high genetic risk for breast cancer. The tool, accessed via WhatsApp, asks women about their family history of cancer. Researchers will compare the AI's risk predictions to the result…

This study is testing if a single dose of an investigational drug called AZD5148 can prevent C. difficile infection from coming back after a person has just been treated for it. About 230 adults who have recently finished antibiotic treatment for a C. diff infection will receive …

This study is checking the safety of a medicine called palivizumab that helps prevent severe RSV lung infections in high-risk children. It involves 138 Indian infants and toddlers under 2 years old who were born very early, have chronic lung disease, or have serious heart conditi…

This study is testing a new drug called AZD7760 to see if it is safe and how it behaves in the body, with the goal of preventing Staphylococcus aureus (staph) infections. It will involve healthy volunteers and, importantly, people with end-stage kidney disease who receive dialysi…

This study is testing if a medication called tezepelumab can improve symptoms for adults with severe chronic sinusitis and nasal polyps who are eligible for surgery. About 180 participants will receive the drug for 24 weeks to see if it reduces nasal congestion, improves smell, a…

This study aims to understand how a drug called acalabrutinib affects the daily life and well-being of people with chronic lymphocytic leukemia (CLL). Researchers will look back at health records and quality-of-life surveys from about 120 patients in France over the first year of…

This study looks back at the medical records of 250 Brazilian patients with advanced non-squamous non-small cell lung cancer whose initial chemotherapy stopped working. The goal is to understand what treatments doctors actually use in real-world clinics after that point and how p…

This study aims to gather detailed information about adults in Russia who have severe asthma that is not well-controlled, even with standard treatments. Researchers will observe 5,000 patients across many regions to understand their health characteristics, the medications they us…

This study aims to see if training hospital doctors on the latest heart failure medication guidelines leads to better treatment for patients when they leave the hospital. Researchers will observe 438 patients with a specific type of heart failure to see if they receive the recomm…

This study aims to understand the real-world experience of over 52,000 patients with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers will collect existing medical records to track patients' symptoms, treatments, quality of life, and healthcare use …

This is the first time a new drug called AZD3974 is being given to people. The main goal is to check if it is safe and to see how the body absorbs and processes it. The study will involve 176 healthy volunteers, including people of Japanese and Chinese descent. Participants will …

This study aims to understand how a drug called itraconazole, often used to treat fungal infections, affects the levels of a new experimental cancer drug (AZD5335) in the body. It will involve about 24 people with advanced ovarian, fallopian tube, or primary peritoneal cancer who…

This study aims to better understand asthma by observing 355 Chinese adults with the condition. Researchers will collect detailed information about patients' symptoms, treatments, and biological markers to identify different types of asthma. The findings may help develop more per…

This study aims to understand the safety of the medication eplontersen when taken during pregnancy or while breastfeeding. Researchers will collect and review health reports from pregnant or breastfeeding individuals who are taking the drug for a rare disease called transthyretin…

This study aims to understand how bladder cancer is currently treated in Russia and how often certain tumor markers appear. Researchers will collect medical records and tumor samples from about 600 patients across 30 centers. The study does not test new treatments; it only observ…

This study aims to collect real-world information on patients with severe, hard-to-control asthma who are prescribed the biologic drug tezepelumab in Italy. It will follow 300 patients for up to two years to understand their characteristics, track their symptoms, and see how well…

This study aims to understand how two different inhaler versions of the same asthma medication are absorbed into the body of children. It will enroll 12 children with asthma, aged 4 to under 12. Each child will try both inhalers in a single dose to compare how the drugs move thro…

This study aims to understand how doctors in Brazil treat patients with advanced non-small cell lung cancer (NSCLC) in real-world settings. Researchers will collect medical record data from 200 patients starting first-line treatment between 2025-2026 and survey about 300 oncologi…

This early-stage study aims to understand how the body absorbs, uses, and eliminates the experimental drug Saruparib in patients with advanced solid tumors. Eight participants will stay in a hospital to receive the drug orally and intravenously while researchers collect blood, ur…

This study is a survey asking Chinese patients with advanced lung cancer and their doctors about their preferences for first-line treatments. It aims to understand what factors—like effectiveness, side effects, and cost—most influence their treatment decisions. The study does not…

This study aims to gather information about people with Chronic Obstructive Pulmonary Disease (COPD) in Moscow who experience frequent symptom flare-ups. Researchers will observe 500 patients over 6 months to understand their health characteristics, the treatments they receive in…

This study aims to understand how well the drug acalabrutinib works for chronic lymphocytic leukemia (CLL) in everyday medical practice in Belarus. It will follow 50 adult patients who have just started taking the drug for about two years, collecting information on how long they …

This study aims to better understand people with chronic obstructive pulmonary disease (COPD) in Russia. Researchers will observe 2000 patients with moderate-to-severe COPD who experience frequent symptom flare-ups. The goal is to describe who these patients are and see what trea…

This study aims to better understand a chronic lung disease called non-cystic fibrosis bronchiectasis (NCFBE) in Chinese patients. Researchers will observe 320 participants, including people with the disease and healthy volunteers, to identify patterns in their symptoms and biolo…

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study looks back at existing medical records to understand how dapagliflozin, a medication already approved for chronic kidney disease, is used and how well it works in routine Spanish healthcare. Researchers will analyze data from over 14,000 patients to see how the drug af…

This large observational study aims to collect real-world information on how patients with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease are currently managed. It will enroll 35,000 adults from many countries to track their treatments, doctor …

This study is creating a large registry to collect information about adults with uncontrolled asthma across Russia. It will observe 9,000 patients receiving standard care (excluding newer biologic drugs) to better understand who is affected, how they are treated, and their health…

This observational study aims to better understand Chronic Obstructive Pulmonary Disease (COPD) in Chinese patients. Researchers will follow 850 participants with COPD or early signs of the disease for 1-3 years, collecting health data, lung function tests, and blood samples. The…

This study aims to see if new weight loss injections (AZD6234 and AZD9550) change how the body processes birth control pills. It will involve 75 healthy women with overweight or obesity. Researchers will measure drug levels in the blood to check for interactions and monitor safet…

This study aims to understand how much of the lupus medication anifrolumab passes into breast milk and reaches nursing infants. It will enroll 16 breastfeeding mothers who are already taking this drug for their lupus. Researchers will collect breast milk and blood samples from mo…

This study is monitoring the safety of the lupus medication anifrolumab by comparing patients who take it against similar patients who receive standard treatments. Researchers will track whether patients develop serious infections or cancers over time. The study is observational,…

This study is testing whether new computer programs (AI algorithms) can help pathologists diagnose lung and breast cancer more quickly and accurately. Researchers will look back at samples from 600 patients in four countries to see how AI compares to standard lab methods. The goa…

This study aims to understand how a single dose of the cancer drug capivasertib is processed by the body in people with moderate liver problems. It will compare 20 participants with liver impairment to a control group with normal liver function. The main goal is to check if the d…

This study aims to understand how well durvalumab-based treatments work for liver and bile duct cancers in real-world medical settings, outside of controlled clinical trials. Researchers will follow approximately 4,490 patients across 22 countries who are already receiving these …

This study aims to understand the real-world impact of a rare and serious kidney disease called atypical hemolytic uremic syndrome (aHUS) in Egypt. Researchers will look back at the medical records of up to 200 patients diagnosed over the past 14 years to describe their symptoms,…

This study aims to collect real-world information on how well a specific combination of immunotherapy and chemotherapy drugs works for patients with advanced non-squamous lung cancer. It will follow 600 patients in Germany who are already scheduled to receive this treatment, focu…

This study aims to collect real-world information on how chronic kidney disease (CKD) is managed in China and what happens to patients over time. It will follow 3,000 adults with CKD for nearly two years, observing their treatments and health outcomes. The goal is to better under…

This study aims to gather detailed information about adults living with neurofibromatosis type 1 (NF1) in Russia. Researchers will observe 200 patients in their regular care settings to document their symptoms, tumor characteristics, overall health, and quality of life. The goal …

This study aims to understand how doctors in Russia currently treat patients with advanced lung cancer that cannot be surgically removed. Researchers will observe the treatment patterns and short-term outcomes for 2,000 patients receiving combined chemotherapy and radiation acros…

This study aims to collect real-world information about patients with advanced endometrial cancer in Russia. Researchers will analyze tumor samples from 500 patients to understand specific genetic and molecular characteristics. The study will also document what first-line treatme…

This study aims to find out if a diabetes medication called exenatide increases the risk of pancreatic cancer compared to other diabetes drugs. Researchers will analyze the health records of 24,000 type 2 diabetes patients across Europe from 2006 to 2023. The study is observation…

This study aims to understand how lung cancer is treated and what it costs the healthcare system in Canada. Researchers will analyze existing health records from 60,000 patients in Alberta and Ontario to see what treatments were used, how long patients lived, and the associated h…

This early-stage study aims to understand how a new drug, opemalirsen, is processed by the body in people with different levels of kidney function compared to people with normal kidney function. About 50 adults, some with kidney impairment and some without, will receive a single …

This study aims to understand how doctors in Russia treat men with a newly diagnosed, aggressive form of prostate cancer that has already spread. Researchers will observe 400 patients to see what treatments they receive and will test their stored tumor samples for specific biolog…

This study aims to observe and document the real-world experiences of people living with ATTR amyloidosis, a rare disease that can damage the heart and nerves. It will follow at least 1850 patients for 3 to 7 years, collecting information from their regular medical visits to unde…

This study is collecting information about pregnancy outcomes in women with moderate to severe lupus who take the medication anifrolumab. Researchers will compare health results for mothers and babies exposed to the drug during pregnancy against those who used other lupus treatme…

This early-stage study aims to understand how the body absorbs and processes different pill versions of an experimental drug called AZD5004. It will involve 64 healthy volunteers who will take single doses of different pill formulations. Researchers will measure drug levels in th…

This study aims to understand what happens to people in Brazil with severe and very severe COPD over one year. It will follow 693 patients from hospitals across the country, tracking how often they are hospitalized, have symptom flare-ups, or pass away. The goal is to gather real…

This study observes how patients with advanced breast cancer respond to an existing medication called trastuzumab deruxtecan in real-world settings. Researchers will track 800 patients in Germany to understand how long the treatment works before patients need new therapy and how …

This is a very early, first-in-human study to check if a new drug called AZD4954 is safe and how it behaves in the body. It will test single and multiple doses in healthy volunteers and people with high cholesterol who also have a specific risk factor called elevated Lp(a). The m…

This early-stage study aims to see if an experimental oral drug, AZD2389, reaches and engages its intended target in the livers of people with advanced liver scarring (fibrosis). Researchers will use special PET scans to measure this in about 12 participants. The main goal is to …

This study is collecting information on how well the drug acalabrutinib works for patients with chronic lymphocytic leukemia (CLL) in real-world UK clinics. It will look back at the medical records of about 350 adults who started this treatment through a special early access prog…

This study is checking if the severe asthma medication tezepelumab increases the risk of serious heart problems like heart attacks or strokes. It will follow over 16,000 teens and adults with severe asthma in four countries, comparing those taking the drug to those on standard tr…

This study aims to understand the safety of the lupus medication anifrolumab during pregnancy. It will follow about 240 women with lupus who took the drug while pregnant, tracking their health and their babies' health for up to a year after birth. The main goal is to check for an…

This study aims to find out how many people with heart disease also have a lung condition called COPD. It will follow 3000 adults with heart conditions to see if a coordinated approach to managing both heart and lung health can reduce hospital visits and improve quality of life. …

This study aims to understand how the genetic makeup of advanced breast cancer changes as patients receive treatment. Researchers will compare blood tests from 70 patients before and after therapy to see if new mutations emerge. The goal is to gather knowledge that may help guide…

This early-stage study aims to understand how a new investigational drug, AZD6793, interacts with the common diabetes medication metformin. It will involve about 28 people with type 2 diabetes who are already taking metformin. The main goal is to see if AZD6793 changes how the bo…

This study observes how approved AstraZeneca lung cancer drugs work in real-world settings, not testing new treatments. It will follow 300 patients with non-small cell lung cancer who are already receiving these drugs as part of their standard care. Researchers will track how lon…

This study aims to understand how ovarian cancer is currently treated in Brazil and what outcomes patients experience. It will follow 250 patients for three years to collect information on their treatments, disease progression, and survival. The goal is to identify strengths and …

This early study aims to understand how eating a meal affects the way the body absorbs and processes a new combination pill containing two drugs, zibotentan and dapagliflozin. It involves 26 healthy volunteers who will take the pill once on an empty stomach and once after a high-…

This study aims to understand how doctors in Russia treat men with aggressive, spreading prostate cancer that is still sensitive to hormone therapy. Researchers will observe 400 patients to see what treatments they receive in real-world practice and compare genetic test results f…

This is the first study in people for a new drug called AZD1613, made by AstraZeneca. It aims to check if the drug is safe, how the body handles it, and what it does in healthy volunteers, including people of Chinese and Japanese descent. The study will give the drug at different…

This French study observes breast cancer patients taking a medication called olaparib for 12 months in real-world settings. Researchers want to see how many patients complete the full treatment course and understand factors that might affect completion. The study collects informa…

This study aims to better understand how a specific genetic change affects the symptoms and progression of hypophosphatasia (HPP), a rare bone and mineral disorder. Researchers will observe 55 children and adults in Russia who have this genetic variant but are not receiving speci…

This study aims to understand how doctors in Russia currently treat adults with a specific form of myasthenia gravis (gMG) in everyday practice. It will observe 450 patients over three years, collecting information from their medical records about the treatments they receive and …

This early-stage study aims to better understand how andexanet, a drug used to reverse the effects of certain blood thinners in emergencies, works and when it's safe to give another blood thinner (enoxaparin) afterward. It involves 186 healthy participants and will measure how th…

This study aims to understand how Neurofibromatosis Type 1 (NF1) affects people in Egypt by collecting health information from 200 patients diagnosed between 2010 and 2023. Researchers will track how the disease progresses over time, what treatments patients receive, and how comm…

This study aims to find out how many smokers visiting heart clinics also have undiagnosed COPD, a serious lung disease. Researchers will enroll 1,000 adult smokers at cardiology clinics to perform breathing tests and questionnaires. The goal is to better understand the link betwe…

This study aims to understand how often people with high blood pressure who show early signs of kidney damage actually get diagnosed with chronic kidney disease (CKD) in Kazakhstan. Researchers will observe over 1,200 adult patients with high blood pressure and specific lab marke…

This study aims to understand how ovarian cancer treatments work in real-world medical practice in Germany. It will follow 750 women with newly diagnosed advanced ovarian cancer who are receiving standard chemotherapy and may get additional maintenance therapy. Researchers will t…

A multicenter real-world observational study of the prevalence, diagnostic pathways, and clinical characteristics of lysosomal acid lipase deficiency in pediatric and adolescent risk groups in the Russian Federation (HELIOS)