New hope for lymphoma: drug combo aims to beat chemo

NCT ID NCT06549595

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Sep 21, 2026 · Updated 6 times

Summary

This phase 3 trial is testing whether a new drug called surovatamig (AZD0486) combined with rituximab works better than standard chemotherapy plus rituximab for people with untreated follicular lymphoma. About 1,018 participants worldwide will be randomly assigned to one of the two treatment groups. The study aims to see if the new combo can delay cancer progression and shrink tumors more effectively.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Surovatamig (AZD0486) plus rituximab
What this could lead to: If successful, this could offer a more targeted, less toxic treatment option for people with untreated follicular lymphoma, potentially improving how long they live without their cancer getting worse.
What could go wrong: This is an early-stage test of the new drug combination, and it may not prove more effective or safer than current standard chemotherapies. Side effects from the new drug are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,018 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Nov 2031

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 130 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participant must be at least 18 years of age, inclusive, at the time of signing the ICF. 2. Histologically confirmed diagnosis of classic FL per WHO 2022 classification 3. ECOG performance status of 0 to 2 4. No prior systemic lymphoma-directed therapy 5. Need for systemic treatment meeting at least 1 GELF criteria 6. FDG-avid and measurable disease 7. Stage II to IV and FLIPI 2-5 \[Phase III only\] 8. Adequate liver, hematological, renal and cardiac function. The above is a summary, other inclusion criteria details may apply Exclusion Criteria: 1. Follicular large B-cell lymphoma (WHO 2022 classification), formerly Follicular lymphoma Grade 3B (WHO 2016 classification) or suspicion for histologic transformation to high-grade/aggressive lymphoma 2. Contra-indication to BR, RCVP, and R-CHOP 3. Participants with or history of CNS lymphoma 4. History of a clinically relevant CNS medical condition or pathology that required treatment in the preceding year, is currently symptomatic or that which the treating investigator considers to have the potential to interfere with the evaluation of safety 5. Presence of \>5000 circulating lymphoma cells 6. Active or uncontrolled infection (including EBV) requiring systemic therapy and which places participant at unacceptable risk if he/she were to participate in the study. If a participant has a history of COVID-19 within 1 month of C1D1 or contracts COVID while on study treatment, participant must have 2 consecutive negative tests (PCR testing is preferable) performed at least 48 hours apart prior to resuming dosing. All symptoms related to COVID-19 infection should have fully resolved before initiating or resuming treatment 7. Known history of hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) The above is a summary, other exclusion criteria details may apply

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Untreated follicular lymphoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

217 sites in 22 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

Research Site
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Huntsville, Alabama, 35805, United States
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Anchorage, Alaska, 99508, United States
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Phoenix, Arizona, 85054, United States
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Clovis, California, 93611, United States
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Los Alamitos, California, 90720, United States
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San Diego, California, 92121, United States
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Santa Monica, California, 90404, United States
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Aurora, Colorado, 80045, United States
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New Haven, Connecticut, 06510, United States
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Newark, Delaware, 19713, United States
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Jacksonville, Florida, 32224, United States
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Atlanta, Georgia, 30322, United States
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Macon, Georgia, 31201, United States
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Evanston, Illinois, 60201, United States
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Peoria, Illinois, 61615, United States
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Fort Wayne, Indiana, 46804, United States
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Des Moines, Iowa, 50309, United States
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Iowa City, Iowa, 52242, United States
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Lexington, Kentucky, 40536, United States
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Louisville, Kentucky, 40207, United States
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Baton Rouge, Louisiana, 70808, United States
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Baltimore, Maryland, 21201, United States
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Bethesda, Maryland, 20817, United States
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Columbia, Maryland, 21044, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48201, United States
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Ypsilanti, Michigan, 48197, United States
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Saint Paul, Minnesota, 55102, United States
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Chesterfield, Missouri, 63017, United States
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Springfield, Missouri, 65807, United States
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Hackensack, New Jersey, 07601, United States
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New Brunswick, New Jersey, 08901, United States
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Albany, New York, 12206, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10016, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Charlotte, North Carolina, 28204, United States
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Wilmington, North Carolina, 28401, United States
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Winston-Salem, North Carolina, 27103, United States
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Blue Ash, Ohio, 45242, United States
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Cincinnati, Ohio, 45219, United States
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Columbus, Ohio, 43210, United States
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Eugene, Oregon, 97401, United States
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Portland, Oregon, 97227, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 78705, United States
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Lubbock, Texas, 79430, United States
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Shenandoah, Texas, 77380, United States
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Tyler, Texas, 75702, United States
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Salt Lake City, Utah, 84112, United States
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Fairfax, Virginia, 22031, United States
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Richmond, Virginia, 23219, United States
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Tacoma, Washington, 98405, United States
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Madison, Wisconsin, 53792, United States
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Milwaukee, Wisconsin, 53226, United States
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Clayton, 3168, Australia
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Darlinghurst, 2010, Australia
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Garran, 2605, Australia
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Heidelberg, 3084, Australia
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Macquarie University, 2109, Australia
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Nedlands, 6009, Australia
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Brussels, 1070, Belgium
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Brussels, 1090, Belgium
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Ghent, 9000, Belgium
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Mechelen, 2800, Belgium
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Porto Alegre, 90035-003, Brazil
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São Paulo, 04501-000, Brazil
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São Paulo, 05652-900, Brazil
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Winnipeg, Manitoba, R3E 0V9, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Chicoutimi, Quebec, G7H 5H6, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Saint-Jérôme, Quebec, J7Z 2V4, Canada
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Beijing, 100044, China
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Beijing, 100142, China
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Beijing, 100730, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610078, China
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Chongqing, 400030, China
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Fuzhou, 350001, China
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Guangzhou, 510000, China
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Guangzhou, 510060, China
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Guangzhou, 510100, China
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Hangzhou, 310003, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230031, China
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Lanzhou, 730000, China
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Nanchang, 330006, China
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Nanchang, 330029, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Shandong, 250117, China
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Shanghai, 200065, China
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Shanghai, 20032, China
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Shenyang, 110001, China
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Shenyang, 110004, China
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Shijiazhuang, 054001, China
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Suzhou, 215006, China
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Tianjin, 300020, China
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Wenzhou, 325000, China
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Wuhan, 430079, China
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Xi'an, 710114, China
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Xiamen, 361003, China
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Zhengzhou, 450000, China
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Zhengzhou, 450008, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Prague, 12808, Czechia
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Aalborg, 9100, Denmark
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Copenhagen, 2100, Denmark
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Odense C, 5000, Denmark
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Roskilde, 4000, Denmark
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Helsinki, 00029, Finland
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Kuopio, 70029, Finland
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Tampere, 33520, Finland
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Bayonne, 64100, France
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Lille, 59037, France
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Montpellier, 34295, France
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Saint-Cloud, 92210, France
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SUSPENDED

Vandœuvre-lès-Nancy, 54511, France
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Berlin, 10967, Germany
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Berlin, 13353, Germany
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Deggendorf, 94469, Germany
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Düsseldorf, 40479, Germany
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Göttingen, 37075, Germany
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Hamburg, 20246, Germany
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Heidelberg, 69120, Germany
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Jena, 07747, Germany
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Karlsruhe, 76133, Germany
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Kiel, 24105, Germany
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Lübeck, 23538, Germany
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Magdeburg, 39120, Germany
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Minden, 32429, Germany
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Münster, 48129, Germany
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Regensburgs, 93049, Germany
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Würzburg, 97080, Germany
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Hong Kong, 999077, Hong Kong
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Budapest, 1088, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Kaposvár, 7400, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7624, Hungary
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Szeged, 6725, Hungary
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Delhi, 110029, India
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Delhi, 110085, India
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Gurugram, 122002, India
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Kolkata, 700160, India
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Nashik, 422002, India
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Surat, 396007, India
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Thiruvananthapuram, 695011, India
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Bunkyō City, 113-8677, Japan
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Chiba, 260-8717, Japan
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Chuo-shi, 409-3898, Japan
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Fukuoka, 812-8582, Japan
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Hirakata-shi, 573-1191, Japan
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Kobe, 650-0047, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Kurashiki-shi, 710-8602, Japan
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Kyoto, 602-8566, Japan
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Minatoku, 105-8470, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Sapporo, 003-0006, Japan
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Sapporo, 060-8638, Japan
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Sunto-gun, 411-8777, Japan
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Toyoake-shi, 470-1192, Japan
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Yamagata, 990-9585, Japan
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Yokohama, 241-8515, Japan
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Gdansk, 80-214, Poland
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Gliwice, 44-102, Poland
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Katowice, 40-519, Poland
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Krakow, 30-727, Poland
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Lublin, 20-081, Poland
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Lublin, 20-090, Poland
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Warsaw, 02-781, Poland
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Wroclaw, 50-019, Poland
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Wroclaw, 53-439, Poland
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San Juan, 00918, Puerto Rico
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Busan, 49201, South Korea
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Busan, 49241, South Korea
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Goyang-si, 10408, South Korea
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Jeonnam, 519-763, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barcelona, 08035, Spain
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Barcelona, 8036, Spain
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El Palmar, 30120, Spain
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Girona, 17007, Spain
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Las Palmas de Gran Canaria, 35020, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Oviedo, 33011, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Falun, 79182, Sweden
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Uppsala, 75185, Sweden
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Changhua, 50006, Taiwan
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 833, Taiwan
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Lukang Township, 505029, Taiwan
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Tainan, 704, Taiwan
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Taipei, 106, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40002, Thailand
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NOT_YET_RECRUITING

Ankara, 6200, Turkey (Türkiye)
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NOT_YET_RECRUITING

Ankara, 6620, Turkey (Türkiye)
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NOT_YET_RECRUITING

Istanbul, 34010, Turkey (Türkiye)
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NOT_YET_RECRUITING

Istanbul, 34854, Turkey (Türkiye)
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NOT_YET_RECRUITING

Izmir, 35340, Turkey (Türkiye)
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RECRUITING

London, EC1M6BQ, United Kingdom
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London, SE5 9RS, United Kingdom
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Newcastle upon Tyne, NE7 7DN, United Kingdom
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Norwich, NR4 7UY, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Southampton, SO16 6YD, United Kingdom